The effect of halofuginone, an inhibitor of collagen type I synthesis, on urethral stricture formation: In vivo and in vitro study in a rat model

Journal of Urology

Volumn 164, Issue 5, 2000, Pages 1776-1780

  Nagler, Arnon ^b   Gofrit, Ofer ^b   Ohana, Meir ^b   Pode, Dov ^b   Genina, Olga ^b   Pines, Mark ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NONE

Author keywords

Alkaloids; Extracellular matrix; Fibroblasts; In situ hybridization

Indexed keywords

COLLAGEN TYPE 1; HALOFUGINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; FIBROBLAST; FIBROSIS; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESTENOSIS; URETHRA STRICTURE;

EID: 0033782394     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)67105-4     Document Type: Article

References (19)

1. Newly diagnosed bulbar urethral strictures: Etiology and outcome of various treatment
2. Direct vision internal urethrotomy. A critical review of 365 operations
3. Urethroplasty management in 100 cases of urethral stricture: A rationale for procedure selection
4. Late onset recurrent penile chordee after successful correction at hypospadias repair
5. Biochemical characterization and quantitation of the collagenous components of urethral stricture tissue
6. Rectus urethromyoplasty of radical prostatectomy anastomosis decrease postoperative incontinence and anastomotic stricture; technique and preliminary results
7. Early events in stricture formation in the guinea pig urethra
8. The ultrastructure of human male urethral stricture
9. In vitro ligation of ureters and urethra modulates fetal mouse bladder explant development
10. Inhibition of collagen synthesis and changes in skin morphology in murine graft versus host disease and tight skin mice: Effect of halofuginone
11. Reduction in pulmonary fibrosis in vivo by halofuginone
12. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis
13. Topically applied halofuginone, an inhibitor of collagen type I transcription, reduced peritendinous fibrous adhesions following surgery
14. Halofuginone - An inhibitor of collagen type I synthesis - Prevents postoperative formation of abdominal adhesions
15. Halofuginone - A novel anti-fibrotic therapy
16. Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: Effect of halofuginone
17. Topical treatment of cutaneous chronic graft versus host disease (cGvHD) with halofuginone: A novel inhibitor of collagen type I synthesis
18. Management of obliterative posttraumatic posterior urethral stricture after failed initial urethroplasty
19. Administration of beta-aminopropionitrile to human beings with urethral strictures: A preliminary report