A novel cell cycle inhibitor stalls replication forks and activates S phase checkpoint

Cell Cycle

Volumn 6, Issue 13, 2007, Pages 1621-1630

  Krishnan, Vaidehi ^a   Dirick, Léon ^b   Hong, Hwa Lim ^a   Lim, Tiffany Siew Joo ^a   San, Ling Si Hoe ^a   Chee, Seng Cheng ^a   Kai, Lee Yap ^a   Ting, Anthony ^a,c   Schwob, Etienne ^b   Surana, Uttam ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^c ATHERSYS INC   (United States)

Author keywords

Anti cancer compound; Cell cycle; Cell cycle inhibitor; Checkpoints; DNA replication; Mitosis

Indexed keywords

2 METHYL 1,8 EPOXY NAPHTHALIMIDE; CELL CYCLE PROTEIN 20; CHECKPOINT KINASE 2; NAPHTHALENE DERIVATIVE; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA BINDING; DNA REPLICATION; DNA SYNTHESIS; DRUG INHIBITION; HUMAN; HUMAN CELL; MITOSIS; MOUSE; NONHUMAN; PULSED FIELD GEL ELECTROPHORESIS; TUMOR VOLUME; TUMOR XENOGRAFT;

MAMMALIA; MUS; SACCHAROMYCETALES;

EID: 34548216867     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.13.4373     Document Type: Article

References (36)

1. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
2. Melo J, Toczyski D. A unified view of the DNA damage checkpoint. Curr Opin Cell Biol 2002; 14:237-45.
3. Shiloh Y. ATM and ATR: Networking cellular response to DNA damage. Curr Opin Genet Dev 2001; 11:71-7.
4. Jimenez GS, Nister M, Stommel JM, Beeche M, Barcarse EA, Zhang XQ, O'Gorman S, Wahl GM. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat Genet 2000; 26:37-43.
5. Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J, Lukas J. Rapid destruction of human Cdc25A in response to DNA damage. Science 2000; 288:1425-9.
6. Longhese MP, Clerici M, Lucchini G. The S phase checkpoint and its regulation in Saccharomyces cerevisiae. Mut Res 2003; 532:41-58.
7. Osborn AJ, Elledge SJ, Zou L. Checking on the fork: The DNA-replication stress-response pathway. Trends Cell Biol 2002; 12:509-16.
8. Sun Z, Fay DS, Marini F, Foiani M, Stern DF. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev 1996; 10:395-406.
9. Tercero JA, Longhese MP, Diffley JF. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 5:1323-36.
10. Pellicioli A, Foiani M. Signal transduction: How rad53 kinase is activated. Curr Biol 2005; 15:R769-71.
11. Weinert TA, Kiser GL, Hartwell LH. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 1994; 8:652-65.
12. Krishnan V, Nirantar S, Crasta K, Cheng AYH, Surana U. DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior. Mol Cell 2004; 16:687-700.
13. Michaelis C, Ciosk R, Nasmyth K. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids. Cell 1997; 91:35-45.
14. Zachariae W, Nasmyth K. Whose end is destruction: Cell division and the anaphase-promoting complex. Genes Dev 1999; 13:2039-58.
15. Nasmyth K. Disseminating the genome: Joining, resolving and separating sister chromatids during mitosis and meiosis. Annu Rev Genet 2001; 35:673-745.
16. Bachant J, Jessen SR, Kavanaugh SE, Fielding CS. The yeast S phase checkpoint enables replicating chromosomes to bi-orient and restrain spindle extension during S phase stress. J Cell Biol 2005; 168:999-1012.
17. Clarke DJ, Segal M, Andrews CA, Rudyak SG, Jensen S, Smith K, Reed SI. S-phase checkpoint controls mitosis via an APC-independent Cdc20p function. Nat Cell Biol 2003; 5:928-35.
18. Visintin R, Prinz S, Amon A. CDC20 and CDH1: A family of substrate specific activators of APC-dependent proteolysis. Science 1997; 278:460-3.
19. Lim HH, Goh PY, Surana U. Cdc20 is essential for APC-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr Biol 1998; 8:231-4.
20. 2/M checkpoint control to mitosis in Saccharomyces cereviasiae. Mol Gen Genet 1996; 253:138-148.
21. Toh GW, Lowendes NF. Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 2003; 31:242-6.
22. Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 1998; 17:159-69.
23. Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: Partners in checkpoint signaling. Science 2001; 294:1713-6.
24. Bartek J, Lukas C, Lukas J. Checking on DNA damage in S phase. Nat Rev Mol Cell Biol 2004; 10:792-80.
25. Ziv Y, Bar-Shira A, Pecker I, Russell O, Jorgensen TJ, Tsarfati I, Shiloh Y. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene 1997; 15:159-67.
26. 1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci 2001; 98:9092-7.
27. Hoppe-Seyler F, Butz K. Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53. J Virol 1993; 67:3111-17.
28. Lorenzo E, Ruiz-Ruiz C, Quesada AJ, Hernandez G, Rodriguez A, Lopez-Rivas A, Redondo JM. Doxorubicin induces apoptosis and nd CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J Biol Chem 2002; 277:10883-92.
29. Hurley LH. DNA and its associated processes as targets for cancer therapy. Nat Rev Cancer 2002; 2:188-200.
30. Nelson SM, Ferguson LR, Denny WA. DNA and the chromosomes-varied targets for chemotherapy. Cell and Chromosomes 2004; 3:2.
31. Wang Y, Beerman TA, Kowalski D. Antitumor drug Adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants. Cancer Res 2001; 61:3787-94.
32. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-70.
33. Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell 2005; 19:607-18.
34. Gupta M, Ali R. Fluorescence studies on the interaction of furocoumarins with DNA in the dark. J Biochem 1984; 95:1253-7.
35. Dunstan HM, Ludlow C, Goehle S, Cronk M, Szankasi P, Evans DR, Simon JA, Lamb JR. Cell-based assays for identification of novel double-strand break-inducing agents. J Natl Cancer Inst 2002; 94:78-9.
36. Lengronne A, Pasero P, Bensimon A, Schwob E. Monitoring S phase progression globally and locally using BrdU incorporation in TK(+) strains. Nucleic Acids Res 2001; 29:1433-42.