Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells

Helicobacter

Volumn 12, Issue 5, 2007, Pages 486-497

  Fukui, Toshiro ^a,b   Nishio, Akiyoshi ^a   Okazaki, Kazuichi ^b   Kasahara, Katsuhiro ^a   Saga, Kazuyuki ^a   Tanaka, Junya ^a   Uza, Norimitsu ^a   Ueno, Satoru ^a   Kido, Masahiro ^a   Ohashi, Shinya ^c   Asada, Masanori ^c   Nakase, Hiroshi ^a   Watanabe, Norihiko ^a   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c Kitano Hospital   (Japan)

Author keywords

CD8+ cytotoxic T cell; Cross priming; Foxp3; Helicobacter associated gastritis; Regulatory T cell

Indexed keywords

BACTERIUM ANTIBODY; CYTOKINE; FAS LIGAND; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; GASTRITIS; GENE EXPRESSION; HELICOBACTER FELIS; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INOCULATION; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MOUSE STRAIN; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; STOMACH MUCOSA; STOMACH PH; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; FORKHEAD TRANSCRIPTION FACTORS; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER FELIS; HELICOBACTER INFECTIONS; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY;

HELICOBACTER; HELICOBACTER FELIS; MUS;

EID: 34548166063     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2007.00536.x     Document Type: Article

References (49)

1. Fox JG, Blanco M, Murphy JC, et al. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect Immun 1993 61 : 2309 15.
2. Mohammadi M, Redline R, Nedrud J, et al. Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred and congenic mouse strains. Infect Immun 1996 64 : 238 45.
3. Roth KA, Kapadia SB, Martin SM, et al. Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology. J Immunol 1999 163 : 1490 7.
4. Eaton KA, Mefford M, Thevenot T. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 2001 166 : 7456 61.
5. Chiba T, Seno H, Marusawa H, et al. Host factors are important in determining clinical outcomes of Helicobacter pylori infection. J Gastroenterol 2006 41 : 1 9.
6. Fukui T, Okazaki K, Tamaki H, et al. Immunogenetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice. Lab Invest 2004 84 : 485 92.
7. Smythies LE, Waites KB, Lindsey JR, et al. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 2000 165 : 1022 9.
8. + regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. Clin Exp Immunol 2003 132 : 393 400.
9. Raghavan S, Suri-Payer E, Holmgren J. Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4CD25 regulatory T cells. Scand J Immunol 2004 60 : 82 8.
10. + CD25 high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect Immun 2003 71 : 1755 62.
11. + CD25 high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun 2005 73 : 523 31.
12. Rad R, Brenner L, Bauer S, et al. CD25(+)/Foxp3(+) T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology 2006 131 : 525 37.
13. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 299 : 1057 61.
14. + regulatory T cells. Nat Immunol 2003 4 : 330 6.
15. + T regulatory cells. Nat Immunol 2003 4 : 337 42.
16. + T cell responses in Helicobacter pylori-infected individuals. Clin Exp Immunol 2001 123 : 81 7.
17. + cytoplasmic granules in actively inflammatory lesions of human chronic gastritis. Lab Invest 2004 84 : 368 75.
18. +) in the antrum mucosa in children with chronic Helicobacter pylori-related inflammation before and after bacteria eradication. Rocz Akad Med Bialymst 2004 49 : 216 8.
19. Stober D, Trobonjaca Z, Reimann J, et al. Dendritic cells pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MHC class I-restricted cytotoxic T cells. Eur J Immunol 2002 32 : 1099 108.
20. Utsugi-Kobukai S, Fujimaki H, Hotta C, et al. MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells. Immunol Lett 2003 89 : 125 31.
21. + T cells. J Immunol 2005 174 : 710 7.
22. + T cells from H. pylori-infected individuals. Clin Immunol 2006 118 : 284 91.
23. + T cells in major histocompatibility complex class II-deficient mice. Science 1991 253 : 1417 20.
24. Kontgen F, Suss G, Stewart C, et al. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol 1993 5 : 957 64.
25. Cosgrove D, Gray D, Dierich A, et al. Mice lacking MHC class II molecules. Cell 1991 66 : 1051 66.
26. Markowitz JS, Rogers PR, Grusby MJ, et al. B lymphocyte development and activation independent of MHC class II expression. J Immunol 1993 150 : 1223 33.
27. Ohana M, Okazaki K, Oshima C, et al. A critical role for IL-7R signaling in the development of Helicobacter felis-induced gastritis in mice. Gastroenterology 2001 121 : 329 36.
28. Sakagami T, Dixon M, O'Rourke J, et al. Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis. Gut 1996 39 : 639 48.
29. Watanabe T, Tada M, Nagai H, et al. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998 115 : 642 8.
30. Mori Y, Fukuma K, Adachi Y, et al. Parietal cell autoantigens involved in neonatal thymectomy-induced murine autoimmune gastritis. Studies using monoclonal autoantibodies. Gastroenterology 1989 97 : 364 75.
31. Tung KS, Smith S, Matzner P, et al. Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies. Am J Pathol 1987 126 : 303 14.
32. Ihan A, Krizman I, Ferlan-Marolt V, et al. HLA-DR expression on CD8 lymphocytes from gastric mucosa in urease-positive and urease-negative gastritis. FEMS Immunol Med Microbiol 1995 10 : 295 9.
33. Calam J. Host mechanisms. are they the key to the various clinical outcomes of Helicobacter pylori infection? Ital J Gastroenterol Hepatol 1997 29 : 375 82.
34. Calam J. Helicobacter pylori modulation of gastric acid. Yale J Biol Med 1999 72 : 195 202.
35. Wang J, Fan X, Lindholm C, et al. Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions. Infect Immun 2000 68 : 4303 11.
36. Rudi J, Kuck D, Strand S, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 1998 102 : 1506 14.
37. Jones NL, Day AS, Jennings HA, et al. Helicobacter pylori induces gastric epithelial cell apoptosis in association with increased Fas receptor expression. Infect Immun 1999 67 : 4237 42.
38. Thompson C, Powrie F, Regulatory T cells. Curr Opin Pharmacol 2004 4 : 408 14.
39. Taylor A, Verhagen J, Blaser K, et al. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology 2006 117 : 433 42.
40. + T regulatory cells. Novartis Found Symp 2003 252 : 115 27 discussion 27-31, 203-10.
41. Ermak TH, Giannasca PJ, Nichols R, et al. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J Exp Med 1998 188 : 2277 88.
42. Eaton KA, Mefford ME. Cure of Helicobacter pylori infection and resolution of gastritis by adoptive transfer of splenocytes in mice. Infect Immun 2001 69 : 1025 31.
43. Blanchard TG, Czinn SJ, Redline RW, et al. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice. Cell Immunol 1999 191 : 74 80.
44. Blecker U, Keymolen K, Levy J, et al. Low prevalence of Helicobacter pylori in the acquired immunodeficiency syndrome. Am J Gastroenterol 1993 88 : 1294.
45. Cacciarelli AG, Marano BJ Jr., Gualtieri NM, et al. Lower Helicobacter pylori infection and peptic ulcer disease prevalence in patients with AIDS and suppressed CD4 counts. Am J Gastroenterol 1996 91 : 1783 4.
46. Lichterfeld M, Lorenz C, Nischalke HD, et al. Decreased prevalence of Helicobacter pylori infection in HIV patients with AIDS defining diseases. Z Gastroenterol 2002 40 : 11 4.
47. Olmos M, Araya V, Pskorz E, et al. Coinfection: Helicobacter pylori/human immunodeficiency virus. Dig Dis Sci 2004 49 : 1836 9.
48. Cai X, Carlson J, Stoicov C, et al. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 2005 128 : 1937 52.
49. + regulatory T cells. J Exp Med 2005 202 : 885 91.