Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness

Critical Care Medicine

Volumn 35, Issue 9 SUPPL., 2007, Pages

  Yasuhara, Shingo ^a   Asai, Akihiro ^a   Sahani, Nita D ^a   Martyn, J A Jeevendra ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis; Autophagy; Burn injury; Multiple organ dysfunction syndrome; Necrosis; Oncosis; Pharmacotherapy; Sepsis

Indexed keywords

APOPTOSIS; AUTOPHAGY; BURN; CELL DEATH; CELL DEGENERATION; CELL REGENERATION; CHEMICAL ANALYSIS; CONFERENCE PAPER; CRITICAL ILLNESS; ENDOPLASMIC RETICULUM; HUMAN; INJURY; MITOCHONDRION; MORPHOGENESIS; MORPHOLOGICAL TRAIT; MULTIPLE ORGAN FAILURE; NECROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEPSIS; SIGNAL TRANSDUCTION;

APOPTOSIS; AUTOPHAGY; CRITICAL ILLNESS; ENDOPLASMIC RETICULUM; HUMANS; MITOCHONDRIA; MULTIPLE ORGAN FAILURE; NECROSIS; SEPSIS; SIGNAL TRANSDUCTION; WOUNDS AND INJURIES;

EID: 34548159807     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000278045.91575.30     Document Type: Conference Paper

References (71)

1. Flemming W: Ueber die Bildung von Richtungsfiguren in Saeugethiereiern beim Untergang Graaf'scher Follikel. Arch Anat EntwGesch 1885; 221-244
2. Nissen F: Ueber das Verhalten der Kerne in den Milchdruesenzellen bei der Absonderung. Arch Mikroskop Anat 1886; 26:337-342
3. Schmaus H: Ueber Karyorrhexis. Virchows Arch Pathol Anat 1894; 138:1-80
4. Kerr JF, Wyllie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257
5. Ihara T, Yamamoto T, Sugamata M, et al: The process of ultrastructural changes from nuclei to apoptotic body. Virchows Arch 1998; 433:443-447
6. Wyllie AH: Apoptosis: Cell death in tissue regulation. J Pathol 1987; 153:313-316
7. Horvitz HR, Sternberg PW, Greenwald IS, et al: Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol 1983; 48(Pt 2):453-463
8. Itoh N, Yonehara S, Ishii A, et al: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991; 66:233-243
9. Majno G, Joris I: Apoptosis, oncosis, and necrosis: An overview of cell death. Am J Pathol 1995; 146:3-15
10. Clarke PG: Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990; 181:195-213
11. Hail N Jr, Carter BZ, Konopleva M, et al: Apoptosis effector mechanisms: A requiem performed in different keys. Apoptosis 2006; 11:889-904
12. Harder T, Simons K: Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr Opin Cell Biol 1997; 9:534-542
13. Gajate C, Mollinedo F: The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells. Blood 2001; 98:3860-3863
14. Shi Y: Caspase activation, inhibition, and reactivation: A mechanistic view. Protein Sci 2004; 13:1979-1987
15. Fearnhead HO, Dinsdale D, Cohen GM: An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes. FEBS Lett 1995; 375:283-288
16. Sahara S, Aoto M, Eguchi Y, et al: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 1999; 401:168-173
17. Liu X, Zou H, Slaughter C, et al: DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997; 89:175-184
18. Sakahira H, Enari M, Nagata S: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998; 391:96-99
19. Fadok VA, Voelker DR, Campbell PA, et al: Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992; 148:2207-2216
20. Hanayama R, Tanaka M, Miwa K, et al: Identification of a factor that links apoptotic cells to phagocytes. Nature 2002; 417:182-187
21. Zamzami N, Marchetti P, Castedo M, et al: Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 1995; 181:1661-1672
22. Zamzami N, Marchetti P, Castedo M, et al: Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995; 182:367-377
23. Susin SA, Zamzami N, Castedo M, et al: Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 1996; 184:1331-1341
24. Korsmeyer SJ: Bcl-2: An antidote to programmed cell death. Cancer Surv 1992; 15:105-118
25. Liu X, Kim CN, Yang J, et al: Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 1996; 86:147-157
26. Du C, Fang M, Li Y, et al: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000; 102:33-42
27. van Loo G, Schotte P, van Gurp M, et al: Endonuclease G: A mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 2001; 8:1136-1142
28. Neame SJ, Rubin LL, Philpott KL: Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol 1998; 142:1583-1593
29. Parrish J, Li L, Klotz K, et al: Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 2001; 412:90-94
30. Nakagawa T, Zhu H, Morishima N, et al: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98-103
31. Szegezdi E, Logue SE, Gorman AM, et al: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006; 7:880-885
32. Reimold AM, Etkin A, Clauss I, et al: An essential role in liver development for transcription factor XBP-1. Genes Dev 2000; 14:152-157
33. Kuwabara K, Matsumoto M, Ikeda J, et al: Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J Biol Chem 1996; 271:5025-5032
34. von Recklinghausen F: Untersuchungen ueber Rachitis und Osteomalacie. Jena, Verlag Gustav Fischer, 1910
35. Liu X, Van Vleet T, Schnellmann RG: The role of calpain in oncotic cell death. Annu Rev Pharmacol Toxicol 2004; 44:349-370
36. Yaginuma H, Sato N, Homma S, et al: Roles of caspases in the programmed cell death of motoneurons in vivo. Arch Histol Cytol 2001; 64:461-474
37. Subramani S: Self-destruction in the line of duty. Dev Cell 2001; 1:6-8
38. Klionsky DJ: Cell biology: Regulated self-cannibalism. Nature 2004; 431:31-32
39. Tsukada M, Ohsumi Y: Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 1993; 333:169-174
40. Portera-Cailliau C, Price DL, Martin LJ: Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum. J Comp Neurol 1997; 378:88-104
41. Mathiasen IS, Sergeev IN, Bastholm L, et al: Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem 2002; 277:30738-30745
42. Demarchi F, Bertoli C, Copetti T, et al: Calpain is required for macroautophagy in mammalian cells. J Cell Biol 2006; 175:595-605
43. Todaro M, Catalano M, Di Liberto D, et al: High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. J Cell Biochem 2002; 86:162-173
44. Scarlatti F, Bauvy C, Ventruti A, et al: Ceramide-mediated macroautophagy involves inhibition of protein kinase B and upregulation of beclin 1. J Biol Chem 2004; 279:18384-18391
45. Yorimitsu T, Nair U, Yang Z, et al: Endoplasmic reticulum stress triggers autophagy. J Biol Chem 2006; 281:30299-30304
46. Staley K, Blaschke AJ, Chun J: Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends. Cell Death Differ 1997; 4:66-75
47. Yasuhara S, Kaneki M, Sugita H, et al: Adipocyte apoptosis after burn injury is associated with altered fat metabolism. J Burn Care Res 2006; 27:367-376
48. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, et al: In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 1995; 21:1465-1468
49. Peitsch MC, Polzar B, Stephan H, et al: Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J 1993; 12:371-377
50. Hayashi R, Ito Y, Matsumoto K, et al: Quantitative differentiation of both free 3′-OH and 5′-OH DNA ends between heat-induced apoptosis and necrosis. J Histochem Cytochem 1998; 46:1051-1059
51. Didenko VV, Hornsby PJ: Presence of double-strand breaks with single-base 3′ overhangs in cells undergoing apoptosis but not necrosis. J Cell Biol 1996; 135:1369-1376
52. Mizushima N, Yamamoto A, Matsui M, et al: In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-1111
53. Asai A, Sahani N, Kaneki M, et al: Primary role of functional ischemia and phosphodiesterase-5 inhibitor therapy in the myofiber damage in muscular dystrophy: A quantitative comparison in a mouse dystrophic model and a pharmacologically induced ischemia model using in vivo microscopy. In Press
54. Lydon A, Martyn JA: Apoptosis in critical illness. Int Anesthesiol Clin 2003; 41:65-77
55. Yasuhara S, Kanakubo E, Perez ME, et al: The 1999 Moyer award: Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats. J Burn Care Rehabil 1999; 20:462-470
56. Westermann S, Vollmar B, Thorlacius H, et al: Surface cooling inhibits tumor necrosis factor-alpha-induced microvascular perfusion failure, leukocyte adhesion, and apoptosis in the striated muscle. Surgery 1999; 126:881-889
57. Avontuur JA, Tutein Nolthenius RP, van Bodegom JW, et al: Prolonged inhibition of nitric oxide synthesis in severe septic shock: A clinical study. Crit Care Med 1998; 26:660-667
58. Zhou M, Wang P, Chaudry IH: Endothelial nitric oxide synthase is downregulated during hyperdynamic sepsis. Biochim Biophys Acta 1997; 1335:182-190
59. Spain DA, Wilson MA, Bar-Natan MF, et al: Nitric oxide synthase inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia. J Trauma 1994; 36:720-725
60. Carter EA, Tompkins RG, Hsu H, et al: Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography. Life Sci 1997; 61:39-44
61. Reinhart K, Menges T, Gardlund B, et al: Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study. Crit Care Med 2001; 29:765-769
62. Singer AJ, McClain SA, Hacht G, et al: Semapimod reduces the depth of injury resulting in enhanced re-epithelialization of partial-thickness burns in swine. J Burn Care Res 2006; 27:40-49
63. Hara H, Friedlander RM, Gagliardini V, et al: Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Nat Acad Sci U S A 1997; 94:2007-2012
64. Fukuzuka K, Rosenberg JJ, Gaines GC, et al: Caspase-3-dependent organ apoptosis early after burn injury. Ann Surg 1999; 229:851-858; discussion 858-859
65. Neviere R, Fauvel H, Chopin C, et al: Caspase inhibition prevents cardiac dysfunction and heart apoptosis in a rat model of sepsis. Am J Respir Crit Care Med 2001; 163:218-225
66. Oberholzer C, Tschoeke SK, Moldawer LL, et al: Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice. J Mol Med 2006; 84:389-395
67. Larche J, Lancel S, Hassoun SM, et al: Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol 2006; 48:377-385
68. Xu L, Fagan SC, Waller JL, et al: Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats. BMC Neurol 2004; 4:7
69. Orlov SN, Hamet P: The death of cardiotonic steroid-treated cells: Evidence of Na+i,K+i-independent H+i-sensitive signalling. Acta Physiol (Oxf) 2006; 187:231-240
70. Yasuhara S, Zhu Y, Matsui T, et al: Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem 2003; 51:873-885
71. Iwata A, Riley BE, Johnston JA, et al: HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem 2005; 280:40282-40292