Hyperglycemia enhances the inhibitory effect of mitochondrial toxins and D,L-homocysteine on the brain production of kynurenic acid

Pharmacological Reports

Volumn 59, Issue 3, 2007, Pages 268-273

  Chmiel Perzyńska, Iwona ^a   Perzyński, Adam ^a   Wielosz, Marian ^a   Urbańska, Ewa M ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Hyperglycemia; In vitro; Kynurenic acid; Mitochondrial toxins; Rat brain

Indexed keywords

3 NITROPROPIONIC ACID; AMINOOXYACETIC ACID; CYSTEINE SULFINIC ACID; GLUCOSE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; HOMOCYSTEINE; KYNURENIC ACID;

AMINO ACID SYNTHESIS; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BRAIN CORTEX; BRAIN DYSFUNCTION; BRAIN SLICE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DISEASE EXACERBATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERGLYCEMIA; IC 50; INHIBITION KINETICS; MALE; MITOCHONDRION; NONHUMAN; PATHOPHYSIOLOGY; RISK FACTOR;

EID: 34548142190     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Alaraj M, Gajkowska B, Cholewinski M, Lazarewicz JW: Hyperglycaemia and intramitochondrial glycogen granules in the brain of mice. Ultrastructural study. Folia Neuropathol, 2004, 42, 113-118.
2. Borlongan CV, Koutouzis TK, Freeman TB, Cahill DW, Sanberg PR: Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motor symptoms of Huntington's disease. Brain Res, 1996, 697, 254-257.
3. Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature, 2001, 414, 813-820.
4. De Luis DA, Fernandez N, Arranz ML, Aller R, Izaola O, Romero E: Total homocysteine levels: relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabetes Complications, 2005, 19, 42-46.
5. Durand P, Prost M, Loreau N, Lussier-Cacan S, Blache D: Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest, 2001, 81, 645-672
6. Guidetti P, Okuno E, Schwarcz R: Characterization of rat brain kynurenine aminotransferases I and II. J Neurosci Res, 1997, 50, 457-465.
7. Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX: The brain metabolite kynurenic acid inhibits alpha 7 nicotinic receptor activity and increases non-alpha 7 nicotinic receptor expression; physiopathological implications. J Neurosci, 2001, 21, 7463-7473.
8. Kocki T, Luchowski P, Luchowska, E, Wielosz M, Turski WA, Urbanska EM: L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II. Neurosci Lett, 2003, 346, 97-100.
9. Li PA, Shuaib A, Miyashita H, He QP, Siesjo BK, Warner DS: Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. Stroke, 2000, 31, 183-192.
10. Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayudu PV, Arnelle DR, Stamler JS: Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA, 1997, 94, 5923-5928.
11. Luchowska E, Luchowski P, Paczek R, Kocki T, Turski WA, Wielosz M, Urbanska EM: Dual effect of D,L-homocysteine and S-adenosylhomocysteine on the brain synthesis of the glutamate receptor antagonist, kynurenic acid. J Neurosci Res, 2005, 79, 375-382.
12. Luchowski P, Luchowska E, Turski WA, Urbanska EM: 1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats. Neurosci Lett, 2002, 330, 49-52.
13. Ludolph AC, He F, Spencer PS, Hammerstad J: 3-Nitro-propionic acid - exogenous animal neurotoxin and possible human striatal toxin. Can J Neurol Sci, 1991, 18, 492-498.
14. Maler JM, Seifert W, Huther G, Wiltfarg J, Ruther E, Komhuber J, Bleich S: Homocysteine induces cell death of rats astrocytes in vitro. Neurosci Lett, 2003, 21, 85-88.
15. Pang Z, Geddes JW: Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J Neurosci, 1997, 17, 3064-3073.
16. Rungger-Brandle E, Dosso AA, Leuenberger PM: Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci, 2000, 41, 1971-1980.
17. Russell JW, Golovoy D, Vincent AM, Mahendru P, Olzmann JA, Mentzer A, Feldman EL: High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J, 2002, 16, 1738-1748.
18. Stazka J, Luchowski P, Urbanska EM: Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid. Eur J Pharmacol, 2005, 517, 217-223.
19. Stone TW: Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci, 2000, 21, 149-154.
20. Turski WA, Dziki M, Urbanska E, Calderazzo-Filho LS, Cavalheiro EA: Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. Synapse, 1991, 7, 173-180.
21. Turski WA, Gramsbergen JBP, Traitler H, Schwarcz R: Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine. J Neurochem, 1989, 52, 1629-1636.
22. Turski WA, Herrling PL, Do KQ: Effects of L-cysteine-sulphinate and L-aspartate, mixed excitatory amino acid agonists, on the membrane potential of rat caudate neurons. Brain Res, 1987, 414, 330-338.
23. Urbanska EM: Mitochondrial toxins with potent neuro-degenerative and convulsive properties - effects on kynurenine metabolism in the brain. In: Kynurenines in the Brain: from Experiments to Clinic. Ed. Vecsei L, Nova Sciences, New York, 2006, 117-131.
24. Urbanska E, Ikonomidou C, Sieklucka M, Turski WA: Aminooxyacetic acid produces excitotoxic lesions in the rat striatum. Synapse, 1991, 9, 129-135.
25. Urbanska EM, Blaszczak P, Saran T, Kleirok Z. Turski WA: Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice. Eur J Pharmacol, 1998, 359, 55-58.
26. Urbanska EM, Dekundy A, Kleinrok Z, Turski WA, Czuczwar SJ: Glutamatergic receptor agonists and brain pathology. In: Highly Selective Neurotoxins. Ed. Kostrzewa RM, Humana Press, Totowa, NJ, 1998, 329-354.
27. Urbanska EM, Kocki T, Saran T, Kleinrok Z, Turski WA: Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists. Neuroreport, 1997, 8, 3501-3505.
28. Zieminska E, Matyja E, Kozlowska H, Stafiej A, Lazarewicz JW: Excitotoxic neuronal injury in acute homocysteine neurotoxicity: role of calcium and mitochondrial alterations. Neurochem Int, 2006, 48, 491-497.
29. Zieminska E, Stafiej A, Lazarewicz JW: Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones. Neurochem Int, 2003, 43, 481-492.