Nucleic Acid Related Compounds. 40. Synthesis and Biological Activities of 5-Alkynyluracil Nucleosides1

Journal of Medicinal Chemistry

Volumn 26, Issue 5, 1983, Pages 661-666

  Clercq, Erik De ^a   Descamps, Johan ^a,c   Balzarini, Jan ^a   Giziewicz, Jerzy ^b   Barr, Philip J ^b,d   Robins, Morris J ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Smith Kline ^*  (Belgium)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; RADIOISOTOPE;

5 ALKYNYL 2' DEOXYURIDINE; 5 ALKYNYLURACIL NUCLEOSIDE; 5 ETHYNYLDEOXYURIDINE; BLOOD AND HEMOPOIETIC SYSTEM; CELL GROWTH; DEOXYURIDINE H 3; DRUG ANALYSIS; DRUG COMPARISON; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; INTOXICATION; KIDNEY; LEUKEMIA L 1210; NONHUMAN; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; THYMIDINE H 3; URACIL ARABINOSIDE PHOSPHATE DERIVATIVE; VACCINIA VIRUS;

ALKYNES; ANIMAL; CELL SURVIVAL; IDOXURIDINE; LEUKEMIA L1210; MICE; RABBITS; SIMPLEXVIRUS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; THYMIDYLATE SYNTHASE; VIRUS REPLICATION;

EID: 0020529728     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00359a008     Document Type: Article

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