Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides

Journal of Medicinal Chemistry

Volumn 48, Issue 14, 2005, Pages 4690-4696

  Janeba, Zlatko ^a,c   Balzarini, Jan ^b   Andrei, Graciela ^b   Snoeck, Robert ^b   De Clercq, Erik ^b   Robins, Morris J ^a  

^a Brigham Young University   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c Moravek Biochemicals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ACICLOVIR; ACYCLIC HYDROCARBON SUBSTITUENT; ANTIVIRUS AGENT; CARBOHYDRATE; CARBON; FUNCTIONAL GROUP; FURO[2,3 D]PYRIMIDINE DERIVATIVE; HYDROXYL GROUP; METHYL GROUP; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA VIRUS; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN CYTOMEGALOVIRUS; NONHUMAN; RNA VIRUS; STEREOCHEMISTRY; TUMOR CELL CULTURE; VARICELLA ZOSTER VIRUS; VIRUS INFECTION; VIRUS REPLICATION;

ACYCLOVIR; ANTIVIRAL AGENTS; CELL LINE; CELL LINE, TUMOR; CYTOMEGALOVIRUS; HERPESVIRUS 3, HUMAN; HUMANS; PYRIMIDINE NUCLEOSIDES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22244433929     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050291s     Document Type: Article

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