Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin- 2(3H)-one base and nucleoside derivatives

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 391-398

  Robins, Morris J ^a   Miranda, Karl ^a,c   Rajwanshi, Vivek K ^a,d   Peterson, Matt A ^a   Andrei, Graciela ^b   Snoeck, Robert ^b   De Clercq, Erik ^b   Balzarini, Jan ^b  

^a Brigham Young University   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d Genelabs Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXYNUCLEOSIDE; 3 (2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (DECYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (DODECYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (HEXYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (OCTYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2,3,5 TRI O ACETYL BETA DEXTRO RIBOFURANOSYL) 6 (DECYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2,3,5 TRI O ACETYL BETA DEXTRO RIBOFURANOSYL) 6 (DODECYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2,3,5 TRI O ACETYL BETA DEXTRO RIBOFURANOSYL) 6 (HEXYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2,3,5 TRI O ACETYL BETA DEXTRO RIBOFURANOSYL) 6 (OCTYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2,3,5 TRI O ACETYL BETA DEXTRO RIBOFURANOSYL) 6 BROMOFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2,3,5 TRI O ACETYL BETA DEXTRO RIBOFURANOSYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (3,5 DI O ACETYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (DECYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (3,5 DI O ACETYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (DODECYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (3,5 DI O ACETYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (HEXYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (3,5 DI O ACETYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 (OCTYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (3,5 DI O ACETYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 6 BROMOFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (3,5 DI O ACETYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 METHYL 6 (OCTYN 1 YL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 METHYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (DECYN 1 YL) 3 (BETA DEXTRO RIBOFURANOSYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (DECYN 1 YL) 3 METHYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (DODECYN 1 YL) 3 (BETA DEXTRO RIBOFURANOSYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (DODECYN 1 YL) 3 METHYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (HEXYN 1 YL) 3 (BETA DEXTRO RIBOFURANOSYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (HEXYN 1 YL) 3 METHYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 (OCTYN 1 YL) 3 (BETA DEXTRO RIBOFURANOSYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 6 BROMO 3 METHYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; FURO[2,3 D]PYRIMIDIN 2(3H) ONE DERIVATIVE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; VARICELLA ZOSTER VIRUS;

ANTIVIRAL AGENTS; CELL LINE; CELL PROLIFERATION; CYTOMEGALOVIRUS; HERPESVIRUS 3, HUMAN; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINE NUCLEOSIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 30444456685     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050867d     Document Type: Article

References (18)

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