The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of l-ascorbic acid: Synthesis, cytostatic, and antiviral activity evaluations

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 749-758

  Gazivoda, Tatjana ^a   Raić Malić, Silvana ^a   Marjanović, Marko ^b   Kralj, Marijeta ^b   Pavelić, Krešimir ^b   Balzarini, Jan ^c   Clercq, Erik De ^c   Mintas, Mladen ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral activities; C 5 substituted uracil derivatives; Cytostatic activities; l Ascorbic acid

Indexed keywords

1 (5 ALLENYLURACIL 1 YL) 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 ALLYLURACIL 1 YL) 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 ETHYNYLURACIL 1 YL) 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 ETHYNYLURACIL 1 YL) 2 (2,3 DIHYDROXY 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 PHENYLURACIL 1 YL) 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 PHENYLURACIL 1 YL) 2 (2,3 DIHYDROXY 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 PROPYNYLURACIL 1 YL) 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 VINYLURACIL 1 YL) 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 (5 VINYLURACIL 1 YL) 2 (2,3 DIHYDROXY 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (2 BROMOVINYL) 6 BROMOURACIL 1 YL] 2 (2,3 DI O BENZYL 2 BROMOBUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (2 BROMOVINYL)URACIL 1 YL] 2 (2,3 DI O BENZYL 2 BUTENE 4 OLIDYLIDENE)ETHANE; 1 [5 (2 ISOPENTENYL)URACIL 1 YL] 2 (2,3 DI O 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (5 BROMOFURAN 2 YL)URACIL 1 YL] 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (5 CHLOROFURAN 2 YL)URACIL 1 YL] 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (FURAN 2 YL)URACIL 1 YL] 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (FURAN 2 YL)URACIL 1 YL] 2 (2,3 DIHYDROXY 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (PHENYLETHYNYL)URACIL 1 YL] 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (PHENYLETHYNYL)URACIL 1 YL] 2 (2,3 DIHYDROXY 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (THIOPHEN 2 YL)URACIL 1 YL] 2 (2,3 DI O BENZYL 2 BUTEN 4 OLIDYLIDENE)ETHANE; 1 [5 (THIOPHEN 2 YL)URACIL 1 YL] 2 (2,3 DIHYDROXY 2 BUTEN 4 OLIDYLIDENE)ETHANE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; ASCORBIC ACID DERIVATIVE; URACIL DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CARCINOMA; CONTROLLED STUDY; COXSACKIE VIRUS B4; CYTOSTASIS; DRUG EFFECT; DRUG INHIBITION; DRUG SYNTHESIS; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IC 50; LARYNX CARCINOMA; NONHUMAN; PANCREAS CARCINOMA; SINDBIS VIRUS; STILLE REACTION; SUBSTITUTION REACTION; UTERINE CERVIX CARCINOMA; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ASCORBIC ACID; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; VIRUSES;

SINDBIS VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 33845296975     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.046     Document Type: Article

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