Novel N7- and N1-substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels

Journal of Medicinal Chemistry

Volumn 50, Issue 17, 2007, Pages 4186-4194

  Strassmaier, Timothy ^a   Karpen, Jeffrey W ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2' O DIMETHYL CYCLIC GMP; 2' O BUTYRYL CYCLIC GMP; 2' O METHYL CYCLIC GMP; 8 (4 CHLOROPHENYLTHIO) CYCLIC GMP; BENZENE DERIVATIVE; CHLORINE DERIVATIVE; CYCLIC AMP; CYCLIC GMP; CYCLIC GMP DERIVATIVE; CYCLIC NUCLEOTIDE GATED CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL A2; CYCLIC NUCLEOTIDE GATED CHANNEL A4; CYCLIC NUCLEOTIDE GATED CHANNEL B1B; ION CHANNEL; MACROGOL; PURINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; DERIVATIZATION; ELECTRIC ACTIVITY; HUMAN; HUMAN CELL; LIGHT; MOLECULAR WEIGHT; NONHUMAN; ODOR; RETINA ROD; SIGNAL TRANSDUCTION;

BINDING SITES; CELL LINE; CYCLIC GMP; HUMANS; ION CHANNEL GATING; OLFACTORY PATHWAYS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; RODS (RETINA); STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 34548125299     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0702581     Document Type: Article

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