Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies

Journal of Medicinal Chemistry

Volumn 48, Issue 18, 2005, Pages 5805-5812

  Strassmaier, Timothy ^a   Uma, Ramalinga ^a   Ghatpande, Ambarish S ^b   Bandyopadhyay, Tapasree ^a   Schaffer, Michelle ^c   Witte, John ^c   McDougal, Patrick G ^c   Brown, R Lane ^a   Karpen, Jeffrey W ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c REED COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(3 AMINOPROPYL)AMINO] N [2 [[4 (BUTYLAMINO)BENZOYL]OXY]ETHYL] N,N DIMETHYLPROPAN 1 AMINIUM ACETATE; CYCLIC NUCLEOTIDE GATED CHANNEL BLOCKING AGENT; TETRACAINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CHEMICAL MODIFICATION; COW; CYCLIC NUCLEOTIDE CHANNEL GATING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC POTENTIAL; HYDROPHOBICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ANIMALS; CATTLE; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; RODS (RETINA); STRUCTURE-ACTIVITY RELATIONSHIP; TETRACAINE; XENOPUS;

EID: 24744461362     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0502485     Document Type: Article

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