Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 1895-1900

  Sabb, Annmarie L ^a   Morris Husbands, G ^a   Tokolics, Joseph ^a   Stein, Reinhardt P ^a   Tasse, Rene P ^a   Boast, Carl A ^a   Moyer, John A ^a   Abou Gharbia, Magid ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 HEXYLTHIO 2 PYRAZINYLOXY) 1 AZABICYCLO[2.2.1]HEPTANE; MUSCARINIC M1 RECEPTOR AGONIST; UNCLASSIFIED DRUG; XANOMELINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; HYPERSALIVATION; NONHUMAN; RAT; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; BRIDGED COMPOUNDS; CARBACHOL; CEREBRAL CORTEX; CHO CELLS; COGNITION DISORDERS; COMPUTER SIMULATION; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MACACA MULATTA; MAZE LEARNING; MODELS, MOLECULAR; MUSCARINIC AGONISTS; PHOSPHATIDYLINOSITOLS; PROTEIN CONFORMATION; PYRAZINES; PYRIDINES; RATS; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; SALIVATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 0033584187     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00313-3     Document Type: Article

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