High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: The role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 3, 2007, Pages 1013-1022

  Manov, Irena ^a   Bashenko, Yulia ^a   Eliaz Wolkowicz, Anat ^a   Mizrahi, Meital ^a   Liran, Oded ^a   Iancu, Theodore C ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DOXORUBICIN; GLYCOPROTEIN P; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARACETAMOL; VERAPAMIL;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; HUMAN; HUMAN CELL; LETHALITY; PRIORITY JOURNAL; ULTRASTRUCTURE;

ACETAMINOPHEN; CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL LINE, TUMOR; DOXORUBICIN; DRUG INTERACTIONS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P-GLYCOPROTEIN;

EID: 34548079796     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.121772     Document Type: Article

References (40)

1. Aden DP, Fogel A, Plotkin S, Damjanov I, and Knowles BB (1979) Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 282:615-616.
2. 2-terminal protein kinase-related cell death pathway. Mol Pharmacol 60:847-856.
3. Bai J and Cederbaum AI (2006) Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels. J Pharmacol Exp Ther 319:1435-1443.
4. 2+ endonuclease DNAS1L3. Basic Clin Pharmacol Toxicol 94:19-29.
5. Boulares AH, Zoltoski AJ, Stoica BA, Cuvillier O, and Smulson ME (2002) Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes. Pharmacol Toxicol 90:38-50.
6. Coradini D and Speranza A (2005) Histone deacetylase inhibitors for treatment of hepatocellular carcinoma. Acta Pharmacol Sin 26:1025-1033.
7. Dai Y and Cederbaum AI (1995) Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells. J Pharmacol Exp Ther 273:1497-1505.
8. Druley TE, Stein WD, and Roninson I (2001) Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry 40:4312-4322.
9. Gewirtz DA (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin. Biochem Pharmacol 57:727-741.
10. Guise S, Braguer D, Carles G, Delacourte A, and Briand C (2001) Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells. J Neurosci Res 63:257-267.
11. Gujral JS, Knight TR, Farhood A, Bajt ML, and Jaeschke H (2002) Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 67:322-328.
12. Hinson JA, Reid AB, McCullough SS, and James LP (2004) Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev 36:805-822.
13. Hoffmann U and Kroemer H (2004) The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance. Drug Metab Rev 36:669-701.
14. Hortobagyi GN (1997) Anthracyclines in the treatment of cancer. An overview. Drugs 54:1-7.
15. Jaeschke and Bajt ML (2006) Intracellular signaling mechanisms of acetaminopheninduced liver cell death. Toxicol Sci 89:31-41.
16. Kobrinsky NL, Hartfield D, Horner H, Maksymiuk A, Minuk GY, White DF, and Feldstein TJ (1996) Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest 14:202-210.
17. Kobrinsky NL, Sjolander DE, Goldenberg JA, and Ortmeier TC (2005) Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue. Pediatr Blood Cancer 45:222-225.
18. Lee ER, Kim JY, Kang YJ, Ahn JY, Kim BW, Choi HY, Jeong MY, and Cho SG (2006a) Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis. Biochem Biophys Acta 1763:958-968.
19. Lee TK, Lau TC, and Ng IO (2002) Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines. Cancer Chemother Pharmacol 49:78-86.
20. Lee YS, Wan J, Kim BJ, Bae MA, and Song BJ (2006b) Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. J Pharmacol Exp Ther 317:202-208.
21. Levanon D, Manov I, and Iancu TC (2004) Qualitative and quantitative analysis of the effects of acetaminophen and N-acetylcysteine on the surface morphology of Hep3B hepatoma cells in vitro. Ultrastruct Pathol 28:3-14.
22. Macanas-Pirard P, Yaacob NS, Lee PC, Holder JC, Hinton RH, and Kass GE (2005) Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells. J Pharmacol Exp Ther 313:780-789.
23. Manov I, Bashenko Y, Hirsh M, and Iancu TC (2006) Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells. Basic Clin Pharmacol Toxicol 99:213-224.
24. Manov I, Hirsh M, and Iancu TC (2002) Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Exp Toxicol Pathol 53:489-500.
25. Manov I, Hirsh M, and Iancu TC (2004) N-Acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. Basic Clin Pharmacol Toxicol 94:213-225.
26. Man XB, Tang L, Qiu XH, Yang LQ, Cao HF, Wu MC, and Wang HY (2004) Expression of cytochrome P4502E1 gene in hepatocellular carcinoma. World J Gastroenterol 10:1565-1568.
27. Nakayama GR, Caton MC, Nova MP, and Parandoosh Z (1997) Assessment of the Alamar Blue assay for cellular growth and viability in vitro. J Immunol Methods 204:205-208.
28. Neuman MG (2002) Synergetic signaling for apoptosis in vitro by ethanol and acetaminophen. Alcohol 27:89-98.
29. Niiya M, Niiya K, Shibakura M, Asaumi N, Yoshida C, Shinagawa K, Teshima T, Ishimaru F, Ikeda K, and TanimotoM(2004) Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells. Oncology 67:310-319.
30. Pétriz J and Garcia-Lopez J (1997) Flow cytometric analysis of P-glycoprotein function using rhodamine 123. Leukemia 11:1124-1130.
31. Posadas I, Vellecco V, Santos P, Prieto-Lloret J, and Cena V (2007) Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line. Br J Pharmacol 150:577-585.
32. Puhlmann U, Ziemann C, Ruedell G, Vorwerk H, Schaefer D, Langebrake C, Schuermann P, Creutzig U, and Reinhardt D (2005) Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells. J Pharmacol Exp Ther 312:346-354.
33. Ray SD and Jena N (2000) A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo. Arch Toxicol 73:594-606.
34. Reszka KJ, Britigan LH, Rasmussen GT, Wagner BA, Burns CP, and Britigan BE (2004) Acetaminophen stimulates the peroxidative metabolism of anthracyclines. Arch Biochem Biophys 427:16-29.
35. Rittierodt M and Harada K (2003) Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression-a special role for endothelial cells. Exp Toxicol Pathol 55:39-44.
36. Sanchez-Prieto R, Rojas JM, Taya Y, and Gutkind JS (2000) A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res 60:2464-2472.
37. Small GW, Somasundaram S, Moore DT, Shi YY, and Orlowski RZ (2003) Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK. J Pharmacol Exp Ther 307:861-869.
38. Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, and Ingram AJ (2002) ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 277:12710-12717.
39. Widmann C, Gibson S, Jarpe MB, and Johnson GL (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180.
40. Wolchok JD, Williams L, Pinto JT, Fleisher M, Krown SE, Hwu WJ, Livingston PO, Chang C, and Chapman PB (2003) Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. Melanoma Res 13:189-196.