p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 7, 2007, Pages 3126-3137

  Kelley, Mary J ^a   Rose, Anastasia ^a   Song, Kaili ^a   Lystrup, Barbara ^a   Samples, John W ^a   Acott, Ted S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE; INTERLEUKIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; ACTIVATING TRANSCRIPTION FACTOR 2; ATF2 PROTEIN, HUMAN; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; ISOENZYME; MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; MAP2K3 PROTEIN, HUMAN; MAP2K6 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL SHAPE; CELL STRUCTURE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRABECULAR MESHWORK; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; METABOLISM; PATHOLOGY; PHASE CONTRAST MICROSCOPY; PHOSPHORYLATION; PLASMID; SWINE;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; BLOTTING, WESTERN; CELL SHAPE; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INTERLEUKIN-1ALPHA; ISOENZYMES; MAP KINASE KINASE 3; MAP KINASE KINASE 6; MATRIX METALLOPROTEINASE 3; MICROSCOPY, PHASE-CONTRAST; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; SIGNAL TRANSDUCTION; SWINE; TRABECULAR MESHWORK; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548076392     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1375     Document Type: Article

References (57)

1. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by Erk, JNK, and p38 protein kinases. Science. 2002;298:1911-1912.
2. Morrison DK, Davis RJ. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol. 2003;19:91-118.
3. Roux PP, Blenis J. Erk and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev. 2004;68:320-344.
4. Davis RJ. Transcriptional regulation by MAP kinases. Mol Reprod Dev. 1995;42:459-467.
5. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997;9:180-186.
6. Ono K, Han J. The p38 signal transduction pathway: activation and function. Cell Signal. 2000;12:1-13.
7. Alexander JP, Acott TS. Involvement of protein kinase C in TNFα regulation of trabecular matrix metalloproteinases and TIMPs. Invest Ophthalmol Vis Sci. 2001;42:2831-2838.
8. Alexander JP, Acott TS. Involvement of Erk-MAP kinase pathway in TNFα regulation of trabecular metalloproteinases and TIMPs. Invest Ophthalmol Vis Sci. 2003;44:164-169.
9. Hosseini M, Rose AY, Song K, et al. IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork. Invest Ophthalmol Vis Sci. 2006;47:1469-1476.
10. Parshley DE, Bradley JMB, Fisk A, et al. Laser trabeculoplasty induces stromelysin expression by trabecular juxtacanalicular cells. Invest Ophthalmol Vis Sci. 1996;37:795-804.
11. Parshley DE, Bradley JMB, Samples JR, Van Buskirk EM, Acott TS. Early changes in matrix metalloproteinases and inhibitors after in vivo laser treatment to the trabecular meshwork. Curr Eye Res. 1995;14:537-544.
12. Bradley JMB, Anderssohn AM, Colvis CM, et al. Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1β and TNFα. Invest Ophthalmol Vis Sci. 2000;41:422-430.
13. Acott TS. Biochemistry of aqueous humor outflow. In: Kaufman PL, Mittag TW, eds. Textbook of Ophthalmology. London: CV Mosby; 1994:1.47-1.78.
14. Acott TS, Wirtz MK. Biochemistry of aqueous outflow. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. St Louis: CV Mosby; 1996:281-305.
15. Zhang X, Schroeder A, Callahan EM, et al. Constitutive signalling pathway activity in trabecular meshwork cells from glaucomatous eyes. Exp Eye Res. 2006;82:968-973.
16. Fleenor DL, Pang IH, Clark AF. Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2003;44:3494-3501.
17. Wilson KP, Fitzgibbon MJ, Caron PR, et al. Crystal structure of p38 mitogen-activated protein kinase. J Biol Chem. 1996;271:27696-27700.
18. Lisnock J, Tebben A, Frantz B, et al. Molecular basis for p38 protein kinase inhibitor specificity. Biochemistry. 1998;37:16573-16581.
19. Lisnock J, Tebben A, Frantz B, et al. Molecular basis for p38 protein kinase inhibitor specificity. Biochemistry. 1999;38:3456.
20. Fitzgerald CE, Patel SB, Becker JW, et al. Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. Nat Struct Biol. 2003;10:764-769.
21. Liacini A, Sylvester J, Li WQ, Zafarullah M. Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol. 2002;21:251-262.
22. Pramanik R, Qi X, Borowicz S, et al. p38 Isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun: the determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem. 2003;278:4831-4839.
23. Efimova T, Broome AM, Eckert RL. A regulatory role for p38 delta MAPK in keratinocyte differentiation: evidence for p38 delta-Erk1/2 complex formation. J Biol Chem. 2003;278:34277-34285.
24. Eckert RL, Efimova T, Balasubramanian S, Crish JF, Bone F, Dashti S. p38 Mitogen-activated protein kinases on the body surface - a function for p38 delta. J Invest Dermatol. 2003;120:823-828.
25. Lui P, Zeng C, Acton S, Cok S, Sexton A, Morrison AR. Effects of p38MAPK isoforms on renal mesangial cell inducible nitric oxide synthase expression. Am J Physiol Cell Physiol. 2004;286:C145-C152.
26. Rossa C Jr, Liu M, Patil C, Kirkwood KL. MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts. Matrix Biol. 2005;24:478-488.
27. Raingeaud J, Gupta S, Rogers JS, et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 1995;270:7420-7426.
28. Polansky JR, Weinreb RN, Baxter JD, Alvarado J. Human trabecular cells, I: establishment in tissue culture and growth characteristics. Invest Ophthalmol Vis Sci. 1979;18:1043-1049.
29. Polansky JR, Weinreb R, Alvarado JA. Studies on human trabecular cells propagated in vitro. Vision Res. 1981;21:155-160.
30. Stamer WD, Seftor RE, Williams SK, Samaha HA, Snyder RW. Isolation and culture of human trabecular meshwork cells by extracellular matrix digestion. Curr Eye Res. 1995;14:611-617.
31. Alexander JP, Samples JR, Van Buskirk EM, Acott TS. Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork. Invest Ophthalmol Vis Sci. 1991;32:172-180.
32. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
33. Alexander JP, Samples JR, Acott TS. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Curr Eye Res. 1998;17:276-285.
34. Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ. MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol. 1996;16:1247-1255.
35. Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol. 1998;8:1049-1057.
36. Braz JC, Bueno OF, Liang Q, et al. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest. 2003;111:1475-1486.
37. Morton S, Davis RJ, Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett. 2004;572:177-183.
38. Morrison D, Kaplan D, Rapp U, Roberts T. Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci USA. 1988;85:8855-8859.
39. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol. 1999;19:2435-2444.
40. Catling AD, Eblen ST, Schaeffer HJ, Weber MJ. Scaffold protein regulation of mitogen-activated protein kinase cascade. Methods Enzymol. 2001;332:368-387.
41. Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kahari VM. Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J Biol Chem. 2002;277:32360-32368.
42. Sirum-Connolly K, Brinckerhoff CE. Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1. Nucleic Acids Res. 1991;19:335-341.
43. Matrisian LM. The matrix-degrading metalloproteinases. Bioessays. 1992;14:455-463.
44. Brinckerhoff CE. Regulation of metalloproteinase gene expression: implications for osteoarthritis. Crit Rev Eukaryotic Gene Expression. 1992;2:145-164.
45. Brinckerhoff CE, Sirum-Connolly KL, Karmilowicz MJ, Auble DT. Expression of stromelysin and stromelysin-2 in rabbit and human. Matrix Suppl. 1992;1:165-175.
46. Matrisian LM. Matrix metalloproteinase gene expression. Ann NY Acad Sci. 1994;732:42-50.
47. Fini M, Cook J, Mohan R, Brinckerhoff C. Regulation of matrix metalloproteinase gene expression. In: Parks W, Mecham RP, eds. Matrix Metalloproteinases. San Diego: Academic Press; 1998:299-356.
48. Sanz L, Moscat J, Diaz-Meco MT. Molecular characterization of a novel transcription factor that controls stromelysin expression. Mol Cell Biol. 1995;15:3164-3170.
49. Kirstein M, Sanz L, Quinones S, Moscat J, Diaz-Meco MT, Saus J. Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. J Biol Chem. 1996;271:18231-18236.
50. Brinckerhoff CE, Plucinska IM, Sheldon LA, O'Connor GT. Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate by not by all-trans-retinoic acid or dexamethasone. Biochemistry. 1986;25:6378-6384.
51. Delany AM, Brinckerhoff CE. Post-transcriptional regulation of collagenase and stromelysin gene. J Cell Biochem. 1992;50:400-410.
52. Zeng G, Millis AJ. Differential regulation of collagenase and stromelysin mRNA in late passage cultures of human fibroblasts. Exp Cell Res. 1996;222:150-156.
53. Lee JC, Kumar S, Griswold DE, Underwood DC, Votta BJ, Adams JL. Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 2000;47:185-201.
54. Knebel A, Morrice N, Cohen P. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J. 2001;20:4360-4369.
55. Knebel A, Haydon CE, Morrice N, Cohen P. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. Biochem J. 2002;367:525-532.
56. Bradley JMB, Vranka JA, Colvis CM, et al. Effects of matrix metalloproteinase activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci. 1998;39:2649-2658.
57. Wang N, Chintala SK, Fini ME, Schuman JS. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med. 2001;7:304-309.