-
1
-
-
1542315585
-
Structure and function of choline kinase isoforms in mammalian cells
-
Aoyama C, Liao HN, Ishidate K. Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res 2004;43:266-81.
-
(2004)
Prog Lipid Res
, vol.43
, pp. 266-281
-
-
Aoyama, C.1
Liao, H.N.2
Ishidate, K.3
-
2
-
-
0025162155
-
Signalling through phosphatidylcholine breakdown
-
Exton JH. Signalling through phosphatidylcholine breakdown. J Biol Chem 1990;265:1-4.
-
(1990)
J Biol Chem
, vol.265
, pp. 1-4
-
-
Exton, J.H.1
-
3
-
-
31544441863
-
Regulatory and catalytic mechanisms of CTP: Phosphocholine cytidylyltransferase
-
Kent C. Regulatory and catalytic mechanisms of CTP: phosphocholine cytidylyltransferase. FASEB J 1998;12:58.
-
(1998)
FASEB J
, vol.12
, pp. 58
-
-
Kent, C.1
-
4
-
-
0029026637
-
Eukaryotic phospholipid biosynthesis
-
Kent C. Eukaryotic phospholipid biosynthesis. Annu Rev Biochem 1995;64:315-43.
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 315-343
-
-
Kent, C.1
-
5
-
-
0034110414
-
Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I
-
Chung TW, Huang JS, Mukherjee JJ, Crilly KS, Kiss Z. Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I. Cell Signal 2000;12: 279-88.
-
(2000)
Cell Signal
, vol.12
, pp. 279-288
-
-
Chung, T.W.1
Huang, J.S.2
Mukherjee, J.J.3
Crilly, K.S.4
Kiss, Z.5
-
6
-
-
0027383940
-
Phosphorylcholine: A novel second messenger essential for mitogenic activity of growth factors
-
Cuadrado A, Carnero A, Dolfi F, Jimenez B, Lacal JC. Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene 1993; 8:2959-68.
-
(1993)
Oncogene
, vol.8
, pp. 2959-2968
-
-
Cuadrado, A.1
Carnero, A.2
Dolfi, F.3
Jimenez, B.4
Lacal, J.C.5
-
7
-
-
0028899688
-
Wortmannin inhibits carcinogen stimulated phosphorylation of ethanolamine and choline
-
Kiss Z, Tomono M. Wortmannin inhibits carcinogen stimulated phosphorylation of ethanolamine and choline. FEBS Lett 1995;358:243-6.
-
(1995)
FEBS Lett
, vol.358
, pp. 243-246
-
-
Kiss, Z.1
Tomono, M.2
-
8
-
-
0024315379
-
The effect of polycyclic aromatic hydrocarbons on choline kinase activity in mouse hepatoma cells
-
Paulson BK, Porter TJ, Kent C. The effect of polycyclic aromatic hydrocarbons on choline kinase activity in mouse hepatoma cells. Biochim Biophys Acta 1989;1004: 274-7.
-
(1989)
Biochim Biophys Acta
, vol.1004
, pp. 274-277
-
-
Paulson, B.K.1
Porter, T.J.2
Kent, C.3
-
9
-
-
0034804982
-
Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells
-
Ramírez de Molina A, Rodriguez-Gonzalez A, Penalva V, Lucas L, Lacal JC. Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells. Biochem Biophys Res Commun 2001;285:873-9.
-
(2001)
Biochem Biophys Res Commun
, vol.285
, pp. 873-879
-
-
Ramírez De Molina, A.1
Rodriguez-Gonzalez, A.2
Penalva, V.3
Lucas, L.4
Lacal, J.C.5
-
10
-
-
0028832567
-
Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines
-
Ratnam S, Kent C. Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines. Arch Biochem Biophys 1995;323: 313-22.
-
(1995)
Arch Biochem Biophys
, vol.323
, pp. 313-322
-
-
Ratnam, S.1
Kent, C.2
-
11
-
-
0037142610
-
Increased choline kinase activity in human breast carcinomas: Clinical evidence for a potential novel antitumor strategy
-
Ramírez de Molina A, Gutiérrez R, Ramos MA, et al. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 2002;21:4317-22.
-
(2002)
Oncogene
, vol.21
, pp. 4317-4322
-
-
Ramírez De Molina, A.1
Gutiérrez, R.2
Ramos, M.A.3
-
12
-
-
0036385709
-
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
-
Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, et al. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun 2002;296:580-3.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 580-583
-
-
Ramírez De Molina, A.1
Rodríguez-González, A.2
Gutiérrez, R.3
-
13
-
-
0030681263
-
Choline kinase inhibitors as a novel approach for antiproliferative drug design
-
Hernández-Alcoceba R, Saniger L, Campos J, et al. Choline kinase inhibitors as a novel approach for antiproliferative drug design. Oncogene 1997;15:2289-301.
-
(1997)
Oncogene
, vol.15
, pp. 2289-2301
-
-
Hernández-Alcoceba, R.1
Saniger, L.2
Campos, J.3
-
14
-
-
0001715433
-
Choline kinase: A novel target for antitumor drugs
-
Lacal JC. Choline kinase: a novel target for antitumor drugs. IDrugs 2001;4:419-26.
-
(2001)
IDrugs
, vol.4
, pp. 419-426
-
-
Lacal, J.C.1
-
15
-
-
1542328239
-
From Ras signalling to ChoK inhibitors: A further advance in anticancer drug design
-
Ramírez de Molina A, Rodríguez-González A, Lacal JC. From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design. Cancer Lett 2004; 206:137-48.
-
(2004)
Cancer Lett
, vol.206
, pp. 137-148
-
-
Ramírez De Molina, A.1
Rodríguez-González, A.2
Lacal, J.C.3
-
16
-
-
0038089964
-
In vivo antitumor activity of choline kinase inhibitors: A novel target for anticancer drug discovery
-
Hernández-Alcoceba R, Fernández F, Lacal JC. In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery. Cancer Res 1999;59: 3112-8.
-
(1999)
Cancer Res
, vol.59
, pp. 3112-3118
-
-
Hernández-Alcoceba, R.1
Fernández, F.2
Lacal, J.C.3
-
17
-
-
4644284916
-
Choline kinase activation is a critical requirement for the proliferation of primary human epithelial cells and breast tumor progression
-
Ramírez de Molina A, bañez-Coronel M, Gutiérrez R, et al. Choline kinase activation is a critical requirement for the proliferation of primary human epithelial cells and breast tumor progression. Cancer Res 2004;64: 6732-9.
-
(2004)
Cancer Res
, vol.64
, pp. 6732-6739
-
-
Ramírez De Molina, A.1
Bañez-Coronel, M.2
Gutiérrez, R.3
-
18
-
-
17944389830
-
Inhibition of choline kinase as specific cytotoxic strategy in oncogene-transformed cells
-
Rodríguez-González A, Ramírez de Molina A, Fernández F, et al. Inhibition of choline kinase as specific cytotoxic strategy in oncogene-transformed cells. Oncogene 2003;22:8803-12.
-
(2003)
Oncogene
, vol.22
, pp. 8803-8812
-
-
Rodríguez-González, A.1
Ramírez De Molina, A.2
Fernández, F.3
-
19
-
-
4644270297
-
Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action
-
Rodríguez-González A, Ramírez de Molina A, Fernández F, Lacal JC. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene 2004;23:8247-59.
-
(2004)
Oncogene
, vol.23
, pp. 8247-8259
-
-
Rodríguez-González, A.1
Ramírez De Molina, A.2
Fernández, F.3
Lacal, J.C.4
-
20
-
-
0033523233
-
Anticancer agents targeting signaling molecules and cancer cell environment: Challenges for drug development?
-
Gelmon KA, Eisenhauer EA, Harris AL, Ratain MJ, Workman P. Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development? J Natl Cancer Inst 1999;91:1281-7.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1281-1287
-
-
Gelmon, K.A.1
Eisenhauer, E.A.2
Harris, A.L.3
Ratain, M.J.4
Workman, P.5
-
21
-
-
0036840774
-
Challenges of PK/PD measurements in modern drug development
-
Workman P. Challenges of PK/PD measurements in modern drug development Eur J Cancer 2002;38: 2189-93.
-
(2002)
Eur J Cancer
, vol.38
, pp. 2189-2193
-
-
Workman, P.1
-
22
-
-
0037237884
-
How much gets there and what does it do?: The need for better pharmacokinetic and pharmacodynamic endpoints in contemporary drug discovery and development
-
Workman P. How much gets there and what does it do?: the need for better pharmacokinetic and pharmacodynamic endpoints in contemporary drug discovery and development Curr Pharm Des 2003;9:891-902.
-
(2003)
Curr Pharm des
, vol.9
, pp. 891-902
-
-
Workman, P.1
-
23
-
-
3242679103
-
Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: Theory and practice
-
Parulekar WR, Eisenhauer EA. Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: theory and practice. J Natl Cancer Inst 2004;96:990-7.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 990-997
-
-
Parulekar, W.R.1
Eisenhauer, E.A.2
-
24
-
-
0026922513
-
Studies of human tumours by MRS: A review
-
Negendank W. Studies of human tumours by MRS: a review. NMR Biomed 1992;5:303-24.
-
(1992)
NMR Biomed
, vol.5
, pp. 303-324
-
-
Negendank, W.1
-
25
-
-
0035104245
-
Imaging biochemistry: Applications to breast cancer
-
Ronen SM, Leach MO. Imaging biochemistry: applications to breast cancer. Breast Cancer Res 2001; 3:36-40.
-
(2001)
Breast Cancer Res
, vol.3
, pp. 36-40
-
-
Ronen, S.M.1
Leach, M.O.2
-
26
-
-
7844235474
-
Measurements of human breast cancer using magnetic resonance spectroscopy: A review of clinical measurements and a report of localized P-31 measurements of response to treatment
-
Leach MO, Verrill M, Glaholm J, et al. Measurements of human breast cancer using magnetic resonance spectroscopy: a review of clinical measurements and a report of localized P-31 measurements of response to treatment NMR Biomed 1998;11:314-40.
-
(1998)
NMR Biomed
, vol.11
, pp. 314-340
-
-
Leach, M.O.1
Verrill, M.2
Glaholm, J.3
-
27
-
-
0036525754
-
H-1-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas
-
Tarnawski R, Sokol M, Pieniazek P, et al. H-1-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas. Int J Radiat Oncol Biol Phys 2002;52:1271-6.
-
(2002)
Int J Radiat Oncol Biol Phys
, vol.52
, pp. 1271-1276
-
-
Tarnawski, R.1
Sokol, M.2
Pieniazek, P.3
-
28
-
-
0032826593
-
On the role of MRS in drug development
-
McSheehy PMJ. On the role of MRS in drug development NMR Biomed 1999;12:402-3.
-
(1999)
NMR Biomed
, vol.12
, pp. 402-403
-
-
McSheehy, P.M.J.1
-
29
-
-
0037128692
-
Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells
-
Al-Saffar NMS, Titley JC, Robertson D, et al. Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells. Br J Cancer 2002;86:963-70.
-
(2002)
Br J Cancer
, vol.86
, pp. 963-970
-
-
Al-Saffar, N.M.S.1
Titley, J.C.2
Robertson, D.3
-
30
-
-
0032958532
-
Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis
-
Ronen SM, DiStefano F, McCoy CL, et al. Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis. Br J Cancer 1999;80: 1035-41.
-
(1999)
Br J Cancer
, vol.80
, pp. 1035-1041
-
-
Ronen, S.M.1
DiStefano, F.2
McCoy, C.L.3
-
31
-
-
0029815158
-
Immortalization and transformation are associated with specific alterations in choline metabolism
-
Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD. Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer Res 1996;56:4630-5.
-
(1996)
Cancer Res
, vol.56
, pp. 4630-4635
-
-
Bhakoo, K.K.1
Williams, S.R.2
Florian, C.L.3
Land, H.4
Noble, M.D.5
-
32
-
-
0027654706
-
Phospholipid metabolites, prognosis and proliferation in human breast carcinoma
-
Smith TAD, Bush C, Jameson C, et al. Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. NMR Biomed 1993;6:318-23.
-
(1993)
NMR Biomed
, vol.6
, pp. 318-323
-
-
Smith, T.A.D.1
Bush, C.2
Jameson, C.3
-
33
-
-
0032893756
-
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
-
Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999;59:80-4.
-
(1999)
Cancer Res
, vol.59
, pp. 80-84
-
-
Aboagye, E.O.1
Bhujwalla, Z.M.2
-
34
-
-
0030036565
-
Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells
-
Ting YLT, Sherr D, Degani H. Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells. Anticancer Res 1996; 16:1381-8.
-
(1996)
Anticancer Res
, vol.16
, pp. 1381-1388
-
-
Ting, Y.L.T.1
Sherr, D.2
Degani, H.3
-
35
-
-
0035793795
-
Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells
-
Ronen SM, Jackson LE, Beloueche M, Leach MO. Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells. Br J Cancer 2002;84:691-6.
-
(2002)
Br J Cancer
, vol.84
, pp. 691-696
-
-
Ronen, S.M.1
Jackson, L.E.2
Beloueche, M.3
Leach, M.O.4
-
36
-
-
0033785989
-
Establishment of an isogenic human colon tumor model for NQO1 gene expression: Application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo
-
Sharp SY, Kelland LR, Valenti MR, et al. Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. Mol Pharmacol 2000;58:1146-55.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 1146-1155
-
-
Sharp, S.Y.1
Kelland, L.R.2
Valenti, M.R.3
-
37
-
-
0344393470
-
Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models
-
Chung YL, Troy H, Banerji U, et al. Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models. J Natl Cancer Inst 2003;95:1624-33.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1624-1633
-
-
Chung, Y.L.1
Troy, H.2
Banerji, U.3
-
38
-
-
0028261732
-
Flow cytometric detection of apoptosis: Comparison of the assays of in situ DNA degradation and chromatin changes
-
Hotz MA, Gong J, Traganos F, Darzynkiewicz Z. Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry 1994;15:237-44.
-
(1994)
Cytometry
, vol.15
, pp. 237-244
-
-
Hotz, M.A.1
Gong, J.2
Traganos, F.3
Darzynkiewicz, Z.4
-
39
-
-
16744368637
-
United Kingdom Co-Ordinating Committee on Cancer Research (UKCCCR) guidelines for the welfare of animals in experimental neoplasia
-
Second Edition
-
Workman P, Twentyman P, Balkwill F, et al. United Kingdom Co-Ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). Br J Cancer 1998;77:1-10.
-
(1998)
Br J Cancer
, vol.77
, pp. 1-10
-
-
Workman, P.1
Twentyman, P.2
Balkwill, F.3
-
40
-
-
0030062465
-
Simultaneous extraction of cellular lipids and water-soluble metabolites: Evaluation by NMR spectroscopy
-
Tyagi RK, Azrad A, Degani H, Salomon Y. Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magn Reson Med 1996;35:194-200.
-
(1996)
Magn Reson Med
, vol.35
, pp. 194-200
-
-
Tyagi, R.K.1
Azrad, A.2
Degani, H.3
Salomon, Y.4
-
41
-
-
41949093884
-
Image selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy
-
Ordidge RJ, Connelly A, Lohman JAB. Image selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J Magn Reson 1986;66:283-94.
-
(1986)
J Magn Reson
, vol.66
, pp. 283-294
-
-
Ordidge, R.J.1
Connelly, A.2
Lohman, J.A.B.3
-
43
-
-
0025340810
-
In vivo proton spectroscopy in presence of eddy currents
-
Klose U. In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med 1990;14:26-30.
-
(1990)
Magn Reson Med
, vol.14
, pp. 26-30
-
-
Klose, U.1
-
44
-
-
18844440356
-
Site dependence of choline concentration in HT29 tumours studied by in vivo 1H MR spectroscopy
-
Madhu B, Troy H, Robinson SP, Howe FA, Stubbs M, Griffiths JR. Site dependence of choline concentration in HT29 tumours studied by in vivo 1H MR spectroscopy [abstract]. Proc Int Soc Magn Reson Med 2003;11:1287.
-
(2003)
Proc Int Soc Magn Reson Med
, vol.11
, pp. 1287
-
-
Madhu, B.1
Troy, H.2
Robinson, S.P.3
Howe, F.A.4
Stubbs, M.5
Griffiths, J.R.6
-
46
-
-
0036219647
-
Translating basic cancer research into new cancer therapeutics
-
Workman P, Kaye SB. Translating basic cancer research into new cancer therapeutics. Trends Mol Med 2002;8:51-9.
-
(2002)
Trends Mol Med
, vol.8
, pp. 51-59
-
-
Workman, P.1
Kaye, S.B.2
-
47
-
-
31544452458
-
Choline kinase knock-down in breast cancer cells using RNA interference is associated with an increase in intracellular lipid droplets and triacylglycerides
-
Glunde K, Raman V, Mori N, Mironchik Y, Bhujwalla ZM. Choline kinase knock-down in breast cancer cells using RNA interference is associated with an increase in intracellular lipid droplets and triacylglycerides [abstract]. Proc Int Soc Magn Reson Med 2004;12:2029.
-
(2004)
Proc Int Soc Magn Reson Med
, vol.12
, pp. 2029
-
-
Glunde, K.1
Raman, V.2
Mori, N.3
Mironchik, Y.4
Bhujwalla, Z.M.5
-
48
-
-
3042562283
-
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
-
Glunde K, Jie C, Bhujwalla ZM. Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res 2004;64:4270-6.
-
(2004)
Cancer Res
, vol.64
, pp. 4270-4276
-
-
Glunde, K.1
Jie, C.2
Bhujwalla, Z.M.3
-
49
-
-
0028146621
-
Coordination of membrane phospholipid synthesis with the cell cycle
-
Jackowski S. Coordination of membrane phospholipid synthesis with the cell cycle. J Biol Chem 1994;269: 3858-67.
-
(1994)
J Biol Chem
, vol.269
, pp. 3858-3867
-
-
Jackowski, S.1
-
50
-
-
0028584213
-
Requirement of phosphatidylcholine for normal progression through the cell cycle in C3H/10T1/2 fibroblasts
-
Tercé F, Brun H, Vance DE. Requirement of phosphatidylcholine for normal progression through the cell cycle in C3H/10T1/2 fibroblasts. J Lipid Res 1994;35:2130-42.
-
(1994)
J Lipid Res
, vol.35
, pp. 2130-2142
-
-
Tercé, F.1
Brun, H.2
Vance, D.E.3
-
51
-
-
0032538421
-
Biochemical and evolutionary significance of phospholipid methylation
-
Walkey CJ, Yu L, Agellon LB, Vance DE. Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem 1998;273:27043-6.
-
(1998)
J Biol Chem
, vol.273
, pp. 27043-27046
-
-
Walkey, C.J.1
Yu, L.2
Agellon, L.B.3
Vance, D.E.4
|