The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis

Shock

Volumn 28, Issue 3, 2007, Pages 353-359

  Wheeler, Derek S ^a,b,c   Lahni, Patrick M ^a,b   Hake, Paul W ^a,b   Denenberg, Alvin G ^a,b,c   Wong, Hector R ^d   Snead, Connie ^d   Catravas, John D ^d   Zingarelli, Basilia ^a,b,c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Cecal ligation and puncture; Flavonoids; Inflammation; Polyphenols; Septic shock; Tea

Indexed keywords

EPIGALLOCATECHIN GALLATE; INDUCIBLE NITRIC OXIDE SYNTHASE; POLYPHENOL;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY MUSCLE; ARTICLE; BIOLOGICAL MONITORING; BLOOD PRESSURE REGULATION; C57BL 6 MOUSE; CECUM; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; HEMODYNAMICS; HYPOTENSION; INTESTINE INJURY; LIGATION; MALE; MEAN ARTERIAL PRESSURE; MIXED INFECTION; MORTALITY; MOUSE; NONHUMAN; PUNCTURE; RAT; SEPSIS; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; SURVIVAL; TEA; TREATMENT OUTCOME;

ANIMALS; BLOOD PRESSURE; CATECHIN; DISEASE MODELS, ANIMAL; GENE EXPRESSION; LUNG; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SURVIVAL RATE;

EID: 34548040244     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e3180485823     Document Type: Article

References (45)

1. Wheeler DS, Wheeler WJ: The medicinal chemistry of tea. Drug Dev Res 61:45-65, 2004.
2. Chen PC, Wheeler DS, Malhotra V, Odoms K, Denenberg AG, Wong HR: A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium. Inflammation 26:233-241, 2002.
3. Lin YL, Lin JK: (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB. Mol Pharmacol 52:465-472, 1997.
4. Yang F, de Villiers WJ, McClain CJ, Varilek GW: Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model. J Nutr 128:2334-2340, 1998.
5. Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, Varilek GW: The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappaB activation by inhibiting IkappaB kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60:528-533, 2001.
6. Wheeler DS, Catravas JD, Odoms K, Denenberg A, Malhotra V, Wong HR: Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells. J Nutr 134:1039-1044, 2004.
7. Aneja R, Hake PW, Burroughs TJ, Denenberg AG, Wong HR, Zingarelli B: Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol Med 10:55-62, 2004.
8. Chan MM, Ho CT, Huang HI: Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production. Cancer Lett 96:23-29, 1995.
9. Chan MM, Fong D, Ho CT, Huang HI: Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. Biochem Pharmacol 54:1281-1286, 1997.
10. Di Paola R, Mazzon E, Carmelo M, Crisafulli C, Genovese T, Di Bella P, Esposito E, Menegazzi M, Meli R, Suzuki H, et al.: Green tea polyphenol extract attenuates zymosan-induced non-septic shock in mice. Shock 26:402-409, 2006.
11. Kim HW, Greenburg AG: Nitric oxide scavenging, alone or with nitric oxide synthesis inhibition, modulates vascular hyporeactivity in rats with intraperitoneal sepsis. Shock 17:423-426, 2002.
12. Giusti-Paiva A, Martinez MR, Cestari F, Vinicius J, da Rocha MJA, Carnio EC, Elias LLK, Antunes-Rodrigues J: Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock 21:271-275, 2004.
13. Symeonides S, Balk RA: Nitrix oxide in the pathogenesis of sepsis. Infect Dis Clin North Am 13:449-463, 1999.
14. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 29:189-201, 1980.
15. Zhang H, Chen X, Teng X, Snead C, Catravas JD: Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells. Biochem Pharmacol 55:1873-1880, 1998.
16. Wong HR, Menendez IY: Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun 262:375-380, 1999.
17. Teng X, Zhang H, Snead C, Catravas JD: A reverse nuclear factor-kappaB element in the rat type II nitric oxide synthase promoter mediates the induction by interleukin-1beta and interferon-gamma in rat aortic smooth muscle cells. Gen Pharmacol 34:9-16, 2000.
18. Zhang H, Teng X, Snead C, Catravas JD: Non-NF-kappaB elements are required for full induction of the rat type II nitric oxide synthase in vascular smooth muscle cells. Br J Pharmacol 130:270-278, 2000.
19. Teng X, Zhang H, Snead C, Catravas JD: Molecular mechanisms of iNOS induction by IL-1beta and IFN-gamma in rat aortic smooth muscle cells. Am J Physiol Cell Physiol 282:C144-C152, 2002.
20. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC: The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 167:695-701, 2003.
21. Angus DC, Wax RS: Epidemiology of sepsis: an update. Crit Care Med 29:109-116, 2001.
22. Zingarelli B, Sheehan M, Wong HR: Nuclear factor-kappaB as a therapeutic target in critical care medicine. Crit Care Med 31(1 suppl):105-111, 2003.
23. Bohrer H, Qui F, Zimmerman T, Zhang Y, Jllmer T, Mannel D, Bottiger BW, Stern DM, Waldherr R, Saeger H-D, et al.: Role of NF-kappaB in the mortality of sepsis. J Clin Invest 100:972-985, 1997.
24. Arnalich F, Garcia-Palomero E, Lopez J, Jimenez M, Madero R, Renart J, Vazquez JJ, Montiel C: Predictive value of nuclear factor kappaB activity and plasma cytokine levels in patients with sepsis. Infect Immun 68:1942-1945, 2000.
25. Pritts TA, Wang Q, Sun X, Fischer DR, Hungness ES, Fischer JE, Wong HR, Hasselgren P-O: The stress response decreases NF-kappaB activation in liver of endotoxemic mice. Shock 18:33-37, 2002.
26. Snyder JG, Prewitt R, Campsen J, Britt LD: PDTC and MG132, inhibitors of NF-kappaB, block endotoxin induced vasodilation of isolated rat skeletal muscle arterioles. Shock 17:304-307, 2002.
27. He P, Noda Y, Sugiyama K: Green tea suppresses lipopolysaccharide-induced liver injury in D-galactosamine-sensitized rats. J Nutr 131:1560-1567, 2001.
28. Matsunaga K, Klein TW, Friedman H, Yamamoto Y: Legionella pneumophila replication in macrophages inhibited by selective immunomodulatory effects on cytokine formation by epigallocatechin gallate, a major form of tea catechins. Infect Immun 69:3947-3953, 2001.
29. Yanagawa Y, Yamamoto Y, Hara Y, Shimamura T: A combination effect of epigallocatechin gallate, a major compound of green tea catechins, with antibiotics on Helicobacter pylori growth in vitro. Curr Microbiol 47:244-249, 2003.
30. Kim HW, Greenburg AG: Nitric oxide scavenging, alone or with nitric oxide synthase inhibition, modulates vascular hyporeactivity in rats with intraperitoneal sepsis. Shock 17:423-426, 2002.
31. Liaw W-J, Chen T-H, Lai Z-Z, Chen S-J, Chen A, Tzao C, Wu J-Y, Wu C-C: Effects of a membrane-permeable radical scavenger, tempol, on intraperitoneal sepsis-induced organ injury in rats. Shock 23:88-96, 2005.
32. Erba D, Riso P, Colombo A, Testolin G: Supplementation of Jurkat T cells with green tea extract decreases oxidative damage due to iron treatment. J Nutr 129:2130-2134, 1999.
33. Javadi P, Bunchman TG, Stromberg PE, Husain KD, Dunne WM, Woolsey CA, Turnbull IR, Hotchkiss RS, Karl IE, Coopersmith CM: High-dose exogenous iron following cecal ligation and puncture increases mortality in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med 32:1178-1185, 2004.
34. Thiemermann C: Nitric oxide and septic shock. Gen Pharmacol 29:159-166, 1997.
35. Vincent JL, Zhang H, Szabo C, Preiser JC: Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 161:1781-1785, 2000.
36. Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabo C: The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 120:259-267, 1997.
37. Zingarelli B, Hasko G, Salzman AL, Szabo C: Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock. Crit Care Med 27:1701-1707, 1999.
38. Hecker M, Cattaruzza M, Wagner AH: Regulation of inducible nitric oxide synthase gene expression in vascular smooth muscle cells. Gen Pharmacol 32:9-16, 1999.
39. Liu SF, Ye X, Malik AB: In vivo inhibition of nuclear factor-kappaB activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J Immunol 159:3976-3983, 1997.
40. Sanae F, Miyaichi Y, Kizu H, Hayashi H: Effects of catechins on vascular tone in rat thoracic aorta with endothelium. Life Sci 71:2553-2562, 2002.
41. Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM: Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med 33:1097-1105, 2002.
42. Sheehan M, Wong HR, Hake PW, Malhotra V, O'Connor M, Zingarelli B: Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Mol Pharmacol 61:953-963, 2002.
43. Sheehan M, Wong HR, Hake PW, Zingarelli B: Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis. Crit Care Med 31:2263-2270, 2003.
44. Hollenberg SM: Mouse models of resuscitated shock. Shock 24:58-63, 2005.
45. Annane D, Sanquer S, Sebille V, Faye A, Djuranovic D, R JC, Gajdos P, Bellissant E: Compartmentalised inducible nitric-oxide synthase activity in septic shock. Lancet 355:1143-1148, 2000.