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Volumn 34, Issue 10, 2007, Pages 1029-1036

β2-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design

Author keywords

2 adrenoceptor genetics; Adrenergic; Asthma; Genetic; Polymorphism; Receptors

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; LONG ACTING DRUG; SHORT ACTING DRUG; BETA 2 ADRENERGIC RECEPTOR;

EID: 34547993334     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04731.x     Document Type: Conference Paper
Times cited : (9)

References (69)
  • 1
    • 34547975894 scopus 로고    scopus 로고
    • NHLBI. WHO. National Institutes of Health Publication no. 95-3659. National Institutes of Health, Bethesda.
    • NHLBI WHO. Global Initiative for Asthma (2005 update). National Institutes of Health Publication no. 95-3659. National Institutes of Health, Bethesda. 2005.
    • (2005) Global Initiative for Asthma (2005 Update).
  • 2
    • 0004327464 scopus 로고    scopus 로고
    • National Asthma Council. National Asthma Council Australia Ltd, Melbourne.
    • National Asthma Council. Asthma Management Handbook. National Asthma Council Australia Ltd, Melbourne. 2006.
    • (2006) Asthma Management Handbook.
  • 3
    • 33747805014 scopus 로고    scopus 로고
    • Pharmacological management of mild or moderate persistent asthma
    • O'Byrne PM, Parameswaran K. Pharmacological management of mild or moderate persistent asthma. Lancet 2006 368 : 794 803.
    • (2006) Lancet , vol.368 , pp. 794-803
    • O'Byrne, P.M.1    Parameswaran, K.2
  • 4
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006 368 : 780 93.
    • (2006) Lancet , vol.368 , pp. 780-93
    • Holgate, S.T.1    Polosa, R.2
  • 5
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
    • Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper. Eur. Respir. J. 2004 23 : 932 46.
    • (2004) Eur. Respir. J. , vol.23 , pp. 932-46
    • Celli, B.R.1    MacNee, W.2
  • 6
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLOS Med. 2006 3 : E442.
    • (2006) PLOS Med. , vol.3
    • Mathers, C.D.1    Loncar, D.2
  • 8
    • 33645778592 scopus 로고    scopus 로고
    • COPDX. An update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence
    • Abramson MJ, Crockett AJ, Frith PA, McDonald CF. COPDX. An update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence. Med. J. Aust. 2006 184 : 342 5.
    • (2006) Med. J. Aust. , vol.184 , pp. 342-5
    • Abramson, M.J.1    Crockett, A.J.2    Frith, P.A.3    McDonald, C.F.4
  • 9
    • 23244450682 scopus 로고    scopus 로고
    • Perspectives on the past decade of asthma genetics
    • Ober C. Perspectives on the past decade of asthma genetics. J. Allergy Clin. Immunol. 2005 116 : 274 8.
    • (2005) J. Allergy Clin. Immunol. , vol.116 , pp. 274-8
    • Ober, C.1
  • 10
    • 33644774556 scopus 로고    scopus 로고
    • Asthma genetics 2006: The long and winding road to gene discovery
    • Ober C, Hoffjan S. Asthma genetics 2006: The long and winding road to gene discovery. Genes Immun. 2006 7 : 95 100.
    • (2006) Genes Immun. , vol.7 , pp. 95-100
    • Ober, C.1    Hoffjan, S.2
  • 11
    • 33746842930 scopus 로고    scopus 로고
    • Overview of the pharmacogenetics of asthma treatment
    • Weiss ST, Litonjua AA, Lange C et al. Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J. 2006 6 : 311 26.
    • (2006) Pharmacogenomics J. , vol.6 , pp. 311-26
    • Weiss, S.T.1    Litonjua, A.A.2    Lange, C.3
  • 12
    • 33747839427 scopus 로고    scopus 로고
    • State of the art. Genetics and genomics of chronic obstructive pulmonary disease
    • Cookson WO. State of the art. Genetics and genomics of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2006 3 : 473 5.
    • (2006) Proc. Am. Thorac. Soc. , vol.3 , pp. 473-5
    • Cookson, W.O.1
  • 13
    • 29544449036 scopus 로고    scopus 로고
    • Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation
    • Johnson M. Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. J. Allergy Clin. Immunol. 2006 117 : 18 24.
    • (2006) J. Allergy Clin. Immunol. , vol.117 , pp. 18-24
    • Johnson, M.1
  • 14
    • 33750742437 scopus 로고    scopus 로고
    • Beyond the dogma: Novel beta2-adrenoceptor signalling in the airways
    • Giembycz MA, Newton R. Beyond the dogma: Novel beta2-adrenoceptor signalling in the airways. Eur. Respir. J. 2006 27 : 1286 306.
    • (2006) Eur. Respir. J. , vol.27 , pp. 1286-306
    • Giembycz, M.A.1    Newton, R.2
  • 15
    • 33644752735 scopus 로고    scopus 로고
    • Beta-adrenoceptor responses of the airways: For better or worse?
    • Broadley KJ. Beta-adrenoceptor responses of the airways: For better or worse? Eur. J. Pharmacol. 2006 533 : 15 27.
    • (2006) Eur. J. Pharmacol. , vol.533 , pp. 15-27
    • Broadley, K.J.1
  • 16
    • 33144476873 scopus 로고    scopus 로고
    • The Salmeterol Multicenter Asthma Research Trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
    • Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM. The Salmeterol Multicenter Asthma Research Trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006 129 : 15 26.
    • (2006) Chest , vol.129 , pp. 15-26
    • Nelson, H.S.1    Weiss, S.T.2    Bleecker, E.R.3    Yancey, S.W.4    Dorinsky, P.M.5
  • 17
    • 0027564307 scopus 로고
    • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects
    • Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am. J. Respir. Cell Mol. Biol. 1993 8 : 334 9.
    • (1993) Am. J. Respir. Cell Mol. Biol. , vol.8 , pp. 334-9
    • Reihsaus, E.1    Innis, M.2    MacIntyre, N.3    Liggett, S.B.4
  • 18
    • 0028068550 scopus 로고
    • Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    • Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994 33 : 9414 19.
    • (1994) Biochemistry , vol.33 , pp. 9414-19
    • Green, S.A.1    Turki, J.2    Innis, M.3    Liggett, S.B.4
  • 19
    • 0029339086 scopus 로고
    • Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells
    • Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 1995 13 : 25 33.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.13 , pp. 25-33
    • Green, S.A.1    Turki, J.2    Bejarano, P.3    Hall, I.P.4    Liggett, S.B.5
  • 20
    • 0027519404 scopus 로고
    • A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor
    • Green SA, Cole G, Jacinto M, Innis M, Liggett SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J. Biol. Chem. 1993 268 : 23 116 21.
    • (1993) J. Biol. Chem. , vol.268 , pp. 23116-21
    • Green, S.A.1    Cole, G.2    Jacinto, M.3    Innis, M.4    Liggett, S.B.5
  • 21
    • 0035876397 scopus 로고    scopus 로고
    • The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)
    • Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). Eur. J. Pharmacol. 2001 421 : 141 7.
    • (2001) Eur. J. Pharmacol. , vol.421 , pp. 141-7
    • Green, S.A.1    Rathz, D.A.2    Schuster, A.J.3    Liggett, S.B.4
  • 22
    • 0032442150 scopus 로고    scopus 로고
    • Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression
    • McGraw DW, Forbes SL, Kramer LA, Liggett SB. Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J. Clin. Invest. 1998 102 : 1927 32.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1927-32
    • McGraw, D.W.1    Forbes, S.L.2    Kramer, L.A.3    Liggett, S.B.4
  • 23
    • 18144364703 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor polymorphism and asthma: True or false?
    • Holloway JW, Yang IA. Beta2-adrenergic receptor polymorphism and asthma: True or false? J. Allergy Clin. Immunol. 2005 115 : 960 2.
    • (2005) J. Allergy Clin. Immunol. , vol.115 , pp. 960-2
    • Holloway, J.W.1    Yang, I.A.2
  • 24
    • 33751207092 scopus 로고    scopus 로고
    • Genetic variability of the beta2 adrenergic receptor and asthma exacerbations
    • Liggett SB. Genetic variability of the beta2 adrenergic receptor and asthma exacerbations. Thorax 2006 61 : 925 7.
    • (2006) Thorax , vol.61 , pp. 925-7
    • Liggett, S.B.1
  • 25
    • 33646852406 scopus 로고    scopus 로고
    • The significance of beta2-adrenergic receptor polymorphisms in asthma
    • Litonjua AA. The significance of beta2-adrenergic receptor polymorphisms in asthma. Curr. Opin. Pulm. Med. 2006 12 : 12 17.
    • (2006) Curr. Opin. Pulm. Med. , vol.12 , pp. 12-17
    • Litonjua, A.A.1
  • 26
    • 1542375252 scopus 로고    scopus 로고
    • Toll-like receptor polymorphisms and allergic disease: Interpreting the evidence from genetic studies
    • Yang IA, Holgate ST, Holloway JW. Toll-like receptor polymorphisms and allergic disease: Interpreting the evidence from genetic studies. Clin. Exp. Allergy 2004 34 : 163 6.
    • (2004) Clin. Exp. Allergy , vol.34 , pp. 163-6
    • Yang, I.A.1    Holgate, S.T.2    Holloway, J.W.3
  • 27
    • 26244444318 scopus 로고    scopus 로고
    • What makes a good genetic association study?
    • Hattersley AT, McCarthy MI. What makes a good genetic association study? Lancet 2005 366 : 1315 23.
    • (2005) Lancet , vol.366 , pp. 1315-23
    • Hattersley, A.T.1    McCarthy, M.I.2
  • 29
    • 33751087760 scopus 로고    scopus 로고
    • Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study
    • Hawkins GA, Tantisira K, Meyers DA et al. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am. J. Respir. Crit. Care Med. 2006 174 : 1101 9.
    • (2006) Am. J. Respir. Crit. Care Med. , vol.174 , pp. 1101-9
    • Hawkins, G.A.1    Tantisira, K.2    Meyers, D.A.3
  • 31
    • 33644905269 scopus 로고    scopus 로고
    • The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma
    • Wilson AM, Gray RD, Hall IP, Lipworth BJ. The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma. Allergy 2006 61 : 254 9.
    • (2006) Allergy , vol.61 , pp. 254-9
    • Wilson, A.M.1    Gray, R.D.2    Hall, I.P.3    Lipworth, B.J.4
  • 32
    • 33750302641 scopus 로고    scopus 로고
    • Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol
    • Palmer CN, Lipworth BJ, Lee S, Ismail T, Macgregor DF, Mukhopadhyay S. Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol. Thorax 2006 61 : 940 4.
    • (2006) Thorax , vol.61 , pp. 940-4
    • Palmer, C.N.1    Lipworth, B.J.2    Lee, S.3    Ismail, T.4    MacGregor, D.F.5    Mukhopadhyay, S.6
  • 33
    • 33750094349 scopus 로고    scopus 로고
    • Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1
    • Brøgger J, Steen VM, Eiken HG, Gulsvik A, Bakke P. Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1. Eur. Respir. J. 2006 27 : 682 8.
    • (2006) Eur. Respir. J. , vol.27 , pp. 682-8
    • Brøgger, J.1    Steen, V.M.2    Eiken, H.G.3    Gulsvik, A.4    Bakke, P.5
  • 34
    • 33646204055 scopus 로고    scopus 로고
    • Beta 2-adrenergic receptor polymorphisms: Pharmacogenetic response to bronchodilator among African American asthmatics
    • Tsai HJ, Shaikh N, Kho JY et al. Beta 2-adrenergic receptor polymorphisms: Pharmacogenetic response to bronchodilator among African American asthmatics. Hum. Genet. 2006 119 : 547 57.
    • (2006) Hum. Genet. , vol.119 , pp. 547-57
    • Tsai, H.J.1    Shaikh, N.2    Kho, J.Y.3
  • 35
    • 33747622353 scopus 로고    scopus 로고
    • Association between nonspecific airway hyperresponsiveness and Arg16Gly beta2-adrenergic receptor gene polymorphism in asymptomatic healthy Japanese subjects
    • Fukui Y, Hizawa N, Takahashi D et al. Association between nonspecific airway hyperresponsiveness and Arg16Gly beta2-adrenergic receptor gene polymorphism in asymptomatic healthy Japanese subjects. Chest 2006 130 : 449 54.
    • (2006) Chest , vol.130 , pp. 449-54
    • Fukui, Y.1    Hizawa, N.2    Takahashi, D.3
  • 36
    • 33745200579 scopus 로고    scopus 로고
    • Association between beta2-adrenergic receptor genetic polymorphisms and nocturnal asthmatic patients of Chinese Han nationality
    • Yin K, Zhang X, Qiu Y. Association between beta2-adrenergic receptor genetic polymorphisms and nocturnal asthmatic patients of Chinese Han nationality. Respiration 2006 73 : 464 7.
    • (2006) Respiration , vol.73 , pp. 464-7
    • Yin, K.1    Zhang, X.2    Qiu, Y.3
  • 37
    • 33745675688 scopus 로고    scopus 로고
    • Molecular-based haplotype analysis of the beta 2-adrenergic receptor gene (ADRB2) in Japanese asthmatic and non-asthmatic subjects
    • Munakata M, Harada Y, Ishida T et al. Molecular-based haplotype analysis of the beta 2-adrenergic receptor gene (ADRB2) in Japanese asthmatic and non-asthmatic subjects. Allergol. Int. 2006 55 : 191 8.
    • (2006) Allergol. Int. , vol.55 , pp. 191-8
    • Munakata, M.1    Harada, Y.2    Ishida, T.3
  • 38
    • 33645120172 scopus 로고    scopus 로고
    • Influence of beta2-adrenergic receptor genotype on airway function during exercise in healthy adults
    • Snyder EM, Beck KC, Dietz NM, Joyner MJ, Turner ST, Johnson BD. Influence of beta2-adrenergic receptor genotype on airway function during exercise in healthy adults. Chest 2006 129 : 762 70.
    • (2006) Chest , vol.129 , pp. 762-70
    • Snyder, E.M.1    Beck, K.C.2    Dietz, N.M.3    Joyner, M.J.4    Turner, S.T.5    Johnson, B.D.6
  • 39
    • 33747760084 scopus 로고    scopus 로고
    • Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: A genetic association study
    • Hall IP, Blakey JD, Al Balushi KA et al. Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: A genetic association study. Lancet 2006 368 : 771 9.
    • (2006) Lancet , vol.368 , pp. 771-9
    • Hall, I.P.1    Blakey, J.D.2    Al Balushi, K.A.3
  • 40
    • 33745109889 scopus 로고    scopus 로고
    • The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans
    • Lima JJ, Holbrook JT, Wang J et al. The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans. J. Asthma 2006 43 : 185 91.
    • (2006) J. Asthma , vol.43 , pp. 185-91
    • Lima, J.J.1    Holbrook, J.T.2    Wang, J.3
  • 42
    • 33749370049 scopus 로고    scopus 로고
    • Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma
    • Bleecker ER, Yancey SW, Baitinger LA et al. Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J. Allergy Clin. Immunol. 2006 118 : 809 16.
    • (2006) J. Allergy Clin. Immunol. , vol.118 , pp. 809-16
    • Bleecker, E.R.1    Yancey, S.W.2    Baitinger, L.A.3
  • 43
  • 44
    • 33645800240 scopus 로고    scopus 로고
    • Tachyphylaxis to beta2-agonists in Spanish asthmatic patients could be modulated by beta2-adrenoceptor gene polymorphisms
    • Telleria JJ, Blanco-Quiros A, Muntion S et al. Tachyphylaxis to beta2-agonists in Spanish asthmatic patients could be modulated by beta2-adrenoceptor gene polymorphisms. Respir. Med. 2006 100 : 1072 8.
    • (2006) Respir. Med. , vol.100 , pp. 1072-8
    • Telleria, J.J.1    Blanco-Quiros, A.2    Muntion, S.3
  • 45
    • 33645000588 scopus 로고    scopus 로고
    • Limited beta2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics
    • van Veen A, Wierenga EA, Westland R et al. Limited beta2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics. Respir. Res. 2006 7 : 19.
    • (2006) Respir. Res. , vol.7 , pp. 19
    • Van Veen, A.1    Wierenga, E.A.2    Westland, R.3
  • 46
    • 33750728633 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle
    • Moore PE, Cunningham G, Calder MM et al. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am. J. Respir. Cell Mol Biol. 2006 35 : 559 64.
    • (2006) Am. J. Respir. Cell Mol Biol. , vol.35 , pp. 559-64
    • Moore, P.E.1    Cunningham, G.2    Calder, M.M.3
  • 47
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • Cardon LR, Bell JI. Association study designs for complex diseases. Nat. Rev. Genet. 2001 2 : 91 9.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 91-9
    • Cardon, L.R.1    Bell, J.I.2
  • 48
    • 0036255811 scopus 로고    scopus 로고
    • Opinion. Candidate-gene approaches for studying complex genetic traits: Practical considerations
    • Tabor HK, Risch NJ, Myers RM. Opinion. Candidate-gene approaches for studying complex genetic traits: Practical considerations. Nat. Rev. Genet. 2002 3 : 391 7.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 391-7
    • Tabor, H.K.1    Risch, N.J.2    Myers, R.M.3
  • 49
    • 0037426052 scopus 로고    scopus 로고
    • Problems of reporting genetic associations with complex outcomes
    • Colhoun HM, McKeigue PM, Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 2003 361 : 865 72.
    • (2003) Lancet , vol.361 , pp. 865-72
    • Colhoun, H.M.1    McKeigue, P.M.2    Davey Smith, G.3
  • 50
    • 33747797059 scopus 로고    scopus 로고
    • Beta2-adrenoreceptor polymorphisms and asthma
    • Wjst M. Beta2-adrenoreceptor polymorphisms and asthma. Lancet 2006 368 : 710 11.
    • (2006) Lancet , vol.368 , pp. 710-11
    • Wjst, M.1
  • 51
    • 0033915078 scopus 로고    scopus 로고
    • The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma
    • Israel E, Drazen JM, Liggett SB et al. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 2000 162 : 75 80.
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 75-80
    • Israel, E.1    Drazen, J.M.2    Liggett, S.B.3
  • 52
    • 6944232728 scopus 로고    scopus 로고
    • Use of regularly scheduled albuterol treatment in asthma: Genotype-stratified, randomised, placebo-controlled cross-over trial
    • Israel E, Chinchilli VM, Ford JG et al. Use of regularly scheduled albuterol treatment in asthma: Genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet 2004 364 : 1505 12.
    • (2004) Lancet , vol.364 , pp. 1505-12
    • Israel, E.1    Chinchilli, V.M.2    Ford, J.G.3
  • 53
    • 33645123005 scopus 로고    scopus 로고
    • Beta-adrenoceptor polymorphisms: Focus moves to long-acting beta-agonists
    • Tattersfield AE, Harrison TW. Beta-adrenoceptor polymorphisms: Focus moves to long-acting beta-agonists. Am. J. Respir. Crit. Care Med. 2006 173 : 473 4.
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , pp. 473-4
    • Tattersfield, A.E.1    Harrison, T.W.2
  • 54
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • Botstein D, Risch N. Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease. Nat. Genet. 2003 33 (Suppl. 228 37.
    • (2003) Nat. Genet. , vol.33 , pp. 228-37
    • Botstein, D.1    Risch, N.2
  • 56
    • 33746124235 scopus 로고    scopus 로고
    • Case-control studies in the genomic era: A clinician's guide
    • Healy DG. Case-control studies in the genomic era: A clinician's guide. Lancet Neurol. 2006 5 : 701 7.
    • (2006) Lancet Neurol. , vol.5 , pp. 701-7
    • Healy, D.G.1
  • 57
    • 0034641736 scopus 로고    scopus 로고
    • Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
    • Drysdale CM, McGraw DW, Stack CB et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl Acad. Sci. USA 2000 97 : 10 483 8.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10483-8
    • Drysdale, C.M.1    McGraw, D.W.2    Stack, C.B.3
  • 58
    • 0034518904 scopus 로고    scopus 로고
    • Polymorphism of the beta (2)-adrenergic receptor gene and desensitization in human airway smooth muscle
    • Moore PE, Laporte JD, Abraham JH et al. Polymorphism of the beta (2)-adrenergic receptor gene and desensitization in human airway smooth muscle. Am. J. Respir. Crit. Care Med. 2000 162 : 2117 24.
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 2117-24
    • Moore, P.E.1    Laporte, J.D.2    Abraham, J.H.3
  • 59
    • 0036007088 scopus 로고    scopus 로고
    • Beta2 adrenoceptor promoter polymorphisms: Extended haplotypes and functional effects in peripheral blood mononuclear cells
    • Lipworth B, Koppelman GH, Wheatley AP et al. Beta2 adrenoceptor promoter polymorphisms: Extended haplotypes and functional effects in peripheral blood mononuclear cells. Thorax 2002 57 : 61 6.
    • (2002) Thorax , vol.57 , pp. 61-6
    • Lipworth, B.1    Koppelman, G.H.2    Wheatley, A.P.3
  • 60
    • 0028301232 scopus 로고
    • Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus
    • Naline E, Zhang Y, Qian Y et al. Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus. Eur. Respir. J. 1994 7 : 914 20.
    • (1994) Eur. Respir. J. , vol.7 , pp. 914-20
    • Naline, E.1    Zhang, Y.2    Qian, Y.3
  • 61
    • 0031926358 scopus 로고    scopus 로고
    • Long- and short-acting beta2 adrenoceptor agonists: Interactions in human contracted bronchi
    • Molimard M, Naline E, Zhang Y, Le Gros V, Begaud B, Advenier C. Long- and short-acting beta2 adrenoceptor agonists: Interactions in human contracted bronchi. Eur. Respir. J. 1998 11 : 583 8.
    • (1998) Eur. Respir. J. , vol.11 , pp. 583-8
    • Molimard, M.1    Naline, E.2    Zhang, Y.3    Le Gros, V.4    Begaud, B.5    Advenier, C.6
  • 64
    • 1442349847 scopus 로고    scopus 로고
    • Comparative pharmacology of human beta-adrenergic receptor subtypes: Characterization of stably transfected receptors in CHO cells
    • Hoffmann C, Leitz MR, Oberdorf-Maass S, Lohse MJ, Klotz KN. Comparative pharmacology of human beta-adrenergic receptor subtypes: Characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch. Pharmacol. 2004 369 : 151 9.
    • (2004) Naunyn Schmiedebergs Arch. Pharmacol. , vol.369 , pp. 151-9
    • Hoffmann, C.1    Leitz, M.R.2    Oberdorf-Maass, S.3    Lohse, M.J.4    Klotz, K.N.5
  • 65
    • 14644421602 scopus 로고    scopus 로고
    • The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors
    • Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br. J. Pharmacol. 2005 144 : 317 22.
    • (2005) Br. J. Pharmacol. , vol.144 , pp. 317-22
    • Baker, J.G.1
  • 66
    • 33847646321 scopus 로고    scopus 로고
    • (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta (2)-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling
    • Molenaar P, Savarimuthu SM, Sarsero D et al. (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta (2)-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling. Naunyn Schmiedebergs Arch. Pharmacol. 2007 375 : 11 28.
    • (2007) Naunyn Schmiedebergs Arch. Pharmacol. , vol.375 , pp. 11-28
    • Molenaar, P.1    Savarimuthu, S.M.2    Sarsero, D.3
  • 67
    • 33745592507 scopus 로고    scopus 로고
    • Statistical false positive or true disease pathway?
    • Todd JA. Statistical false positive or true disease pathway? Nat. Genet. 2006 38 : 731 3.
    • (2006) Nat. Genet. , vol.38 , pp. 731-3
    • Todd, J.A.1
  • 69
    • 33845364352 scopus 로고    scopus 로고
    • Genes, environments, development and asthma: A reappraisal
    • Martinez FD. Genes, environments, development and asthma: A reappraisal. Eur. Respir. J. 2007 29 : 179 84.
    • (2007) Eur. Respir. J. , vol.29 , pp. 179-84
    • Martinez, F.D.1


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