The effect of the enantiomers of formoterol on inherent and induced tone in guinea-pig trachea and human bronchus

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 4, 2000, Pages 405-409

  Schmidt, D ^a   Rabe, K F ^a   Kallstrom B L ^b   Waldeck, B ^b   Branscheid, D ^c   Magnussen, H ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ASTRAZENECA R AND D   (Sweden)

^c KRANKENHAUS GROSSHANSDORF   (Germany)

Author keywords

Airway tone; Enantiomers; Formoterol; Guinea pig trachea; Human bronchus; Relaxation

Indexed keywords

FORMOTEROL;

ANIMAL TISSUE; ARTICLE; BRONCHUS MUSCLE; BRONCHUS TONE; DRUG EFFECT; DRUG POTENCY; ENANTIOMER; GUINEA PIG; MALE; NONHUMAN; SMOOTH MUSCLE CONTRACTION; TRACHEA;

ADRENERGIC BETA-AGONISTS; ANIMALS; BRONCHI; BRONCHODILATOR AGENTS; CARBACHOL; ETHANOLAMINES; GUINEA PIGS; HUMANS; MALE; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH; RECEPTORS, ADRENERGIC, BETA-2; STEREOISOMERISM; TRACHEA;

EID: 0034013676     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900213     Document Type: Article

References (14)

1. Bartow RA, Brogden RN (1998) Formoterol, an update of its pharmacological properties and therapeutic efficacy in the management of asthma. Drugs 55:303-322
2. Chapman ID, Buchheit KH, Manley P, Morley J (1992) Active enantiomers may cause adverse effects in asthma. Trends Pharmacol Sci 13:231-232
3. Jeppsson A-B, Johansson U, Waldeck B (1984) Steric aspects of agonism and antagonism at β-adrenoceptors: Experiments with the enantiomers of terbutaline and pindolol. Acta Pharmacol Toxicol 54:285-291
4. Jeppsson A-B, Källström B-L, Waldeck B (1992) Studies on the interaction between formoterol and salmeterol in guinea-pig trachea in vitro. Pharmacol Toxicol 71:272-277
5. 2-adrenoceptor agonists with higher efficacy on guinea-pig trachea and human bronchus in vitro. Br J Pharmacol 113:687-692
6. Källström B-L, Sjöberg J, Waldeck B (1996) Steric aspects of formoterol and terbutaline: Is there an adverse effect of the distomer on airway smooth muscle function? Chirality 8:567-573
7. Kenakin TP (1987) Stimulus-response mechanisms. In: Kenakin TP (ed) Pharmacologie Analysis of Drug-receptor Interaction. Raven, New York, pp 31-51
8. Mazzoni L, Naef R, Chapman ID, Morley J (1994) Hyperresponsiveness of the airways following exposure of guinea-pigs to racemic mixtures and distomers of beta 2-selective sympathomimetics. Pulm Pharmacol Ther 7:367-376
9. 2-adrenoceptor agonists: Interactions in human contracted bronchi. Eur Respir J 11:583-588
10. Templeton AGB, Chapman ID, Chilvers ER, Morley J, Handley DA (1998) Effects of S-salbutamol on human isolated bronchus. Pulm Pharmacol Ther 11:1-6
11. 2-sympathomimetics contribute to their relaxant effects in airway smooth muscle cells? Pulm Pharmacol Ther 11:253-261
12. Trofast J, Österberg K, Källström B-L, Waldeck B (1991) Steric aspects of agonism and antagonism at β-adrenoceptors: Synthesis of and pharmacological experiments with the enantiomers of formoterol and their diastereomers. Chirality 3:443-450
13. Waldeck B (1993) Biological significance of the enantiomeric purity of drugs. Chirality 5:350-355
14. 2-adrenoceptor agonists: Is there a cause for concern? J Allergy Clin Immunol 103:742-748