Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation

Molecular Therapy

Volumn 3, Issue 6, 2001, Pages 901-910

  Yao, Qingping ^a   Wang, Sujing ^a   Glorioso, Joseph C ^a   Evans, Christopher H ^b   Robbins, Paul D ^a   Ghivizzani, Steven C ^b   Oligino, Thomas J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adenovirus; Apoptosis; Arthritis; Gene therapy; p53

Indexed keywords

PROTEIN P53;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; AUTOIMMUNE DISEASE; BONE DESTRUCTION; CARTILAGE DEGENERATION; CELL CULTURE; CELL CYCLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; HYPERPLASIA; LEUKOCYTE; MUTATION; NONHUMAN; PATHOGENESIS; RABBIT; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM; TUMOR SUPPRESSOR GENE; VIRUS INFECTION;

ADENOVIRIDAE; ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0034964006     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0343     Document Type: Article

References (40)

1. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?
2. Local proliferating of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining
3. Activation of synoviocytes
4. Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis
5. Differential expression of the small inducible cytokines GRO alpha and GRO beta by synovial fibroblasts in chronic arthritis: Possible role in growth regulation
6. Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts
7. Fibroblast biology: Effector signals released by the synovial fibroblast in arthritis
8. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
9. Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis
10. Oncogene activation in rheumatoid synovium
11. Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis
12. Oncogenes in rheumatoid arthritis
13. Apoptosis in rheumatoid arthritis synovium
14. Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium
15. The p53 network
16. p53, the cellular gatekeeper for growth and division
17. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
18. Three distinct signaling responses by murine fibroblasts to genotoxic stress
19. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium
20. Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium
21. Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases
22. p53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors
23. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
24. Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis
25. p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis
26. Regulation of p53 stability and activity in response to genotoxic stress
27. Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue
28. Dominant-negative p53 mutations in rheumatoid arthritis
29. Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis
30. Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining
31. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
32. Advances in adenoviral vectors: From genetic engineering to their biology
33. Human adenovirus vectors for gene transfer into mammalian cells
34. A new technique for the assay of infectivity of human adenovirus 5 DNA
35. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
36. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
37. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
38. HIG-82: An established cell line from rabbit periarticular soft tissue which retains the "activatable" phenotype
39. Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis
40. Apoptosis and p53 expression in rat adjuvant arthritis