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Ghrelin action in the brain controls adipocyte metabolism
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This is a very complete description of ghrelin actions on white and brown adipose tissue, demonstrating the physiological relevance of central ghrelin in the control of adipocyte metabolism
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Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006; 116:1983-1993. This is a very complete description of ghrelin actions on white and brown adipose tissue, demonstrating the physiological relevance of central ghrelin in the control of adipocyte metabolism.
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52
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Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia
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In cancer cachexia, weight gain and lean-body-mass retention are improved by ghrelin and synthetic ghrelin agonists
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Deboer MD, Zhu XX, Levasseur P, et al. Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology 2007; 148:3004-3012. In cancer cachexia, weight gain and lean-body-mass retention are improved by ghrelin and synthetic ghrelin agonists.
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Endocrinology
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Deboer, M.D.1
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53
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Is ghrelin a signal of decreased fat-free mass in elderly subjects?
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Bertoli S, Magni P, Krogh V, et al. Is ghrelin a signal of decreased fat-free mass in elderly subjects? Eur J Endocrinol 2006; 155:321-330.
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Deletion of ghrelin impairs neither growth nor appetite
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Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 2003; 23:7973-7981.
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Absence of ghrelin protects against early-onset obesity
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Wortley KE, Del Rincon JP, Murray JD, et al. Absence of ghrelin protects against early-onset obesity. J Clin Invest 2005; 115:3573-3578.
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Cummings DE, Clement K, Purnell JQ, et al. Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 2002; 8:643-644.
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DelParigi A, Tschop M, Heiman ML, et al. High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. J Clin Endocrinol Metab 2002; 87:5461-5464.
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58
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A lesser postprandial suppression of plasma ghrelin in Prader-Willi syndrome is associated with low fasting and a blunted postprandial PYY response
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Oxf, In PWS, the postprandial decrease in ghrelin concentrations is lower in PWS compared to lean and obese subjects and might be related to the low fasting PYY concentrations
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Gimenez-Palop O, Gimenez-Perez G, Mauricio D, et al. A lesser postprandial suppression of plasma ghrelin in Prader-Willi syndrome is associated with low fasting and a blunted postprandial PYY response. Clin Endocrinol (Oxf) 2007; 66:198-204. In PWS, the postprandial decrease in ghrelin concentrations is lower in PWS compared to lean and obese subjects and might be related to the low fasting PYY concentrations.
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Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syndrome
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Paik KH, Choe YH, Park WH, et al. Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syndrome. J Clin Endocrinol Metab 2006; 91:1876-1881.
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Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
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Sun Y, Asnicar M, Saha PK, et al. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 2006; 3:379-386.
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Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
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Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001; 50:227-232.
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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Cowley MA, Smart JL, Rubinstein M, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411:480-484.
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Nagaya N, Kojima M, Kangawa K. Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia. Intern Med 2006; 45:127-134.
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Nagaya, N.1
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65
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Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa
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This study suggests that ghrelin might not be useful for anorexia-nervosa-induced cachexia because these patients seem less sensitive to ghrelin in terms of appetite than healthy controls
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Miljic D, Pekic S, Djurovic M, et al. Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa. J Clin Endocrinol Metab 2006; 91:1491-1495. This study suggests that ghrelin might not be useful for anorexia-nervosa-induced cachexia because these patients seem less sensitive to ghrelin in terms of appetite than healthy controls.
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J Clin Endocrinol Metab
, vol.91
, pp. 1491-1495
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Miljic, D.1
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Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
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Asakawa A, Inui A, Kaga T, et al. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 2003; 52:947-952.
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Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats
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Beck B, Richy S, Stricker-Krongrad A. Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sci 2004; 76:473-478.
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68
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Ghrelin neutralization by an RNA-Spiegelmer ameliorates obesity in diet-induced obese mice
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Shearman LP, Wang SP, Helmling S, et al. Ghrelin neutralization by an RNA-Spiegelmer ameliorates obesity in diet-induced obese mice. Endocrinology 2005; 147:1517-1526.
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Kobelt P, Helmling S, Stengel A, et al. Antighrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 2006; 55:788-792. This is an excellent paper demonstrating the efficiency of antighrelin oligonucleotides on appetite and food intake.
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Kobelt P, Helmling S, Stengel A, et al. Antighrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 2006; 55:788-792. This is an excellent paper demonstrating the efficiency of antighrelin oligonucleotides on appetite and food intake.
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70
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Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice
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Shearman LP, Wang SP, Helmling S, et al. Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice. Endocrinology 2006; 147:1517-1526.
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Endocrinology
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Shearman, L.P.1
Wang, S.P.2
Helmling, S.3
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71
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33748354456
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Vaccination against weight gain
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This paper describes a new approach to inhibit the endogenous ghrelin. Vaccination against ghrelin decreases ghrelin levels and might slowweight gain by reducing feed efficiency
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Zorrilla EP, Iwasaki S, Moss JA, et al. Vaccination against weight gain. Proc Natl Acad Sci USA 2006; 103:13226-13231. This paper describes a new approach to inhibit the endogenous ghrelin. Vaccination against ghrelin decreases ghrelin levels and might slowweight gain by reducing feed efficiency.
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Proc Natl Acad Sci USA
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Zorrilla, E.P.1
Iwasaki, S.2
Moss, J.A.3
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High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist
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Holst B, Cygankiewicz A, Jensen TH, et al. High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Mol Endocrinol 2003; 17:2201-2210.
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Holst B, Schwartz TW. Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci 2004; 25:113-117.
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Trends Pharmacol Sci
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