Ultradian ghrelin pulsatility is disrupted in morbidly obese subjects after weight loss induced by malabsorptive bariatric surgery

American Journal of Clinical Nutrition

Volumn 83, Issue 5, 2006, Pages 1017-1024

  Mingrone, Geltrude ^a,c   Granato, Luigi ^b   Valera Mora, Elena ^a   Iaconelli, Amerigo ^a   Calvani, Menotti F ^a   Bracaglia, Roberto ^a   Manco, Melania ^a   Nanni, Giuseppe ^a   Castagneto, Marco ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Appetite; Biliopancreatic diversion; Energy intake; Ghrelin; Insulin sensitivity; Morbid obesity; Pulsatility

Indexed keywords

GHRELIN; INSULIN; PEPTIDE HORMONE;

ADULT; ARTICLE; BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; BODY COMPOSITION; CALORIC INTAKE; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; MALABSORPTION; MORBID OBESITY; WEIGHT REDUCTION; BLOOD; BODY MASS; ENERGY METABOLISM; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; PERIODICITY;

ACTIVITY CYCLES; ADULT; BILIOPANCREATIC DIVERSION; BODY COMPOSITION; BODY MASS INDEX; ENERGY INTAKE; ENERGY METABOLISM; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; OBESITY, MORBID; PEPTIDE HORMONES; WEIGHT LOSS;

EID: 33745161862     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/83.5.1017     Document Type: Article

References (35)

1. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-13.
2. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-8.
3. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000;141:4325-8.
4. Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337-45.
5. Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000;141:4255-61.
6. Cummings DE, Purnell JQ, Frayo RS, et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001;50:1714-9.
7. Shiiya T, Nakazato M, Mizuta M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002;87:240-4.
8. English PJ, Ghatei MA, Malik IA, et al. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 2002;87:2984-7.
9. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002;346:1623-30.
10. Holdstock C, Engstrom BE, Ohrvall M, et al. Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab 2003;88:3177-83.
11. Consensus Development Conference Panel. Gastrointestinal surgery for severe obesity: Consensus Development Conference statement. Ann Intern Med 1991;115:956-61.
12. Kaltenbach M. Manger correctement; mais comment? (To eat correctly; but how?) Zurich, Switzerland: Fédèration des Cooperatives Migros, 1994 (in French).
13. Heresbach D, Flourie B, Briet F, Achour L, Rambaud JC, Messing B. Effect of colonic fermentation on respiratory gas exchanges measured in the postabsorptive state. Am J Clin Nutr 1995;62:973-8.
14. Scopinaro N, Gianetta E, Civalleri D, et al. Bilio-pancreatic bypass for obesity: II. Initial experience in man. Br J Surg 1979;66:618-20.
15. Heymsfield SB, Lichtman S, Baumgartner RN, et al. Body composition of humans: comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure. Am J Clin Nutr 1990;52:52-8.
16. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-23.
17. 2, and RQ in a respiratory chamber: accurate estimation based on a new mathematical model using the Kalman-Bucy method. J Appl Physiol 2004;96:1045-54.
18. Press WH, Teukolsky SA, Vetterling WT, et al. Numerical recipes in C: the art of scientific computing. 2nd ed. NewYork: Cambridge University Press, 1992:537-49.
19. Calvani M, Scarfone A, Granato L, et al. Restoration of adiponectin pulsatility in severely obese subjects after weight loss. Diabetes 2004; 53:939-47.
20. Munson PJ, Roadbard D. Pulse detection in hormone data: simplified, efficient algorithm. In: Proceedings of the Statistical Computing Section of the American Statistical Association, Washington, DC, 1989:295-300. Internet: www.http://abs.cit.nih.gov/pulsefit/pulshtml.html (accessed 1 April 2004).
21. Natalucci G, Riedl S, Gleiss A, Zidek T, Frisch H. Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern Eur J Endocrinol 2005;152:845-50.
22. Cummings DE, Scott Frayo R, Marmonier C, Aubert R, Chapelot D. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues Am J Physiol Endocrinol Metab 2004;287:E297-304.
23. Simpfendorfer CH, Szomstein S, Rosenthal R. Laparoscopic gastric bypass for refractory morbid obesity. Surg Clin North Am 2005;85:119-27.
24. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60.
25. Lee HM, Wang G, Englander EW, et al. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002;143:185-90.
26. Sakata I, Nakamura K, Yamazaki M, et al. Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides 2002;23:531-6.
27. Ariyasu H, Takaya K, Tagami T, et al. Stomach is a major source of circulating ghrelin and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001;86:4753-8.
28. Adami GF, Cordera R, Andraghetti G, et al. Changes in serum ghrelin concentration following biliopancreatic diversion for obesity. Obes Res 2004;12:684-7.
29. Adami GF, Gandolfo P, Cocchi FH, et al. Binge eating following bilio-pancreatic diversion for obesity. Appetite 1995;25:177-88.
30. Tomasetto C, Wendling C, Rio MC, et al. Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus. Peptides 2001;22:2055-9.
31. Moesgaard SG, Ahren B, Carr RD, et al. Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach. Regul Pept 2004;120:261-7.
32. Schaller G, Schmidt A, Pleiner J, et al. Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo-controlled crossover clamp study. Diabetes 2003;52:16-20.
33. Mingrone G, De Gaetano A, Greco AV, et al. Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids. Diabetologia 1997;40:599-605.
34. Ikezaki A, Hosoda H, Ito K, et al. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 2002;51:3408-11.
35. McLaughlin T, Abbasi F, Lamendola C, et al. Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J Clin Endocrinol Metab 2004;89:1630-5.