Practical approaches of taste masking technologies in oral solid forms

Expert Opinion on Drug Delivery

Volumn 4, Issue 4, 2007, Pages 417-426

  Douroumis, Dionysios ^a  

^a Phoqus Pharmaceuticals Limited   (United Kingdom)

Author keywords

Fast dissolving tables; Inclusion complextion; Microencapsulation; Solid dispersions; Taste masking

Indexed keywords

ALAVERT; ANTIOXIDANT; BENADRYL FASTMELT; CETIRIZINE; DIMETAPP; DIPHENHYDRAMINE; ELASTOMER; EMULSIFYING AGENT; EUDRAGIT; EXCEDRIN; EXCEDRIN QUICKTABS; EXCIPIENT; FAMOTIDINE; FILLER; FLAVORING AGENT; GLYCEROL STEARATE; HYDROXYPROPYLMETHYLCELLULOSE; HYOSCYAMINE; LORATADINE; MAXALT MLT; METHACRYLIC ACID; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; MIRTAZAPINE; NULEV; OLANZAPINE; ONDANSETRON; PARACETAMOL; PEPCID RPD; PEPSID RPD; REMERON SOLTABS; RESIN; RIZATRIPTAN; SILDENAFIL; SWEETENING AGENT; TEMPRA FIRSTABS; TRIAMINIC; TRIAMINIC SOFTCHEWS; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLMITRIPTAN;

BITTER TASTE; BLISTER PACK; CHEMICAL MODIFICATION; CHEWABLE TABLET; DRUG COATING; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG INDUSTRY; DRUG PACKAGING; DRUG SOLUBILITY; EFFERVESCENT TABLET; FREEZE DRYING; MASKING; MICROENCAPSULATION; PALATABILITY; PATIENT COMPLIANCE; REVIEW; SPRAY DRYING; TABLET COMPRESSION; TABLET FORMULATION; TECHNOLOGY;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; HUMANS; KINETICS; MASTICATION; PATIENT COMPLIANCE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TABLETS; TASTE; TECHNOLOGY, PHARMACEUTICAL;

EID: 34547855904     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.4.4.417     Document Type: Review

References (26)

1. HABIBH W, KHANKARIK R, HONTZ J: Fast-dissolve drug delivery system. Crit. Rev. Ther. Drug Carrier Syst. (2000) 17:61-72.
2. LOYD A: Flavors and flavoring. Int. J. Pharm. Compounding (1997) 1:90-92.
3. SEAGER H: Drug-deliver Products and the zydis fast-dissolving dosage form. J. Pharm. Pharmacol. (1998) 50:375-382.
4. CHANG RK, GUO X, BURNSIDE B, COUCH R: Fast-dissolving tablets, Pharm. Technol. (2000) 24:52-58.
5. PROULX SM, MELCHIORREM HA: New dosage forms lead to confusion. US Pharm. (2001) 26:68-70.
6. SMITH AJ, MORAN J, DANGLER LV, LEIGHT RS, ADDY M: The efficacy of an anti-gingivitis chewing gum. J. Clin. Periodontol. (1996) 23:19-21.
7. HYRUP B, ANDRESEN C, ANDREASEN LV, TANDRUP B, CHRISTENSEN T: The MediChew® technology platform. Expert Opin. Drug. Deliv. (2005) 2:927-933.
8. KAWASHIMA Y, NIWA T, HANDA T, TAKEUSHI H, IWAMOTO T, ITOH K: Preparation of controlled-released microspheres of ibuprofen with acrylic polymers by a novel quasiemulsion solvent diffusion method. J. Pharm. Sci. (1989A) 78:68-72.
9. KAWASHIMA Y, NIWA T, HANDA T, TAKEUSHI H, IWAMOTO T, ITOH K: Preparation of prolonged-released spherical micromatrix of ibuprofen with acrylic polymer by the emulsion-solvent diffusion method for improving bioavailability. Chem. Pharm. Bull. (1989B) 37:425-429.
10. SJOQVISTS R, GRAFFEER C, EKMAN J: In vitro validation of the release rate and paratability of remoxipride-modified release suspension. Pharm. Res. (1993) 10:1020-1030.
11. GOUIN S: Microencapsulation: industrial appraisal of existing technologies and trends. Trends Food Sci. Technol. (2004) 15:330-347.
12. NII T, ISHII F: Encapsulation efficiency of water-soluble and insoluble drugs in liposomes prepared by the microencapsulation vesicle method. Int. J. Pharm. (2005) 298:198-205.
13. YANG, FU-DE, YING G, LEI Y, YONG-SHENGY W, LI-NA Z: Preparation of roxithromycin-polymeric microspheres by the emulsion solvent diffusion method for taste masking: Int. J. Pharm. (2006) 318:62-69.
14. QI S, DEUTSCH D, CRAIQ DQ: An investigation into the interaction between taste masking fatty acid microspheres and alkaline buffer using thermal and spectroscopic analysis. Pharm. Sci. (2006) 95:1022-1028.
15. FUNASAKI N, KAWAGUCHI R, HADA S, NEYAN S: Ultraviolet spectroscopicestimation of microenvironments and bitter tastes of oxyphenonium bromide in cyclodextrin solutions. J. Pharm. Sci. (1999) 88:759-762.
16. CHALLA R, AHUJA A, ALI J, KHAR RK: Cyclodextrins in drug delivery: an updated review. AAPS Pharm. Sci. Tech. (2005) 6:E329-E357.
17. SZEJTLI J: Cyclodextrin Technology. Kluwer Academic Publishers: Dordrecht, The Netherlands (1988): Chapters 3 and 7.
18. FRÖMMING K.H, SZEJTLI J: Cyclodextrin in Pharmacy. Kluwer Academic Publishers: Dordrecht, The Netherlands (1994): Chapters 1 and 4-8.
19. FUNASAKI N, UEMURA Y, HADA S, NEYA S: Reduction of the bitter taste intensity of propantheline bromide by cyclodextrins as predicted by surface tension measurements. J. Phys. Chem. (1996) 100:16298-16301.
20. FUNASAKI N, KAWAGUCHI R, ISHIKAWA S, HADA S, NEYA S, KATSU T: Quantitative estimation of the bitter taste intensity of oxyphenonium bromide reduced by cyclodextrins from electromotive force measurements. Anal. Chem. (1999) 71:1733-1736.
21. ANON: Taste masking β-lactam antibiotics with macroreticular resins. Res. Discl. (1978) 176:12-13.
22. NANDA A, KANDAPARU R, GARG S: An update on taste masking technologies for oral pharmaceuticals. Indian J. Pharm. Sci. (2002) 64(1):10-17.
23. MANEK SP, KAMAT VS: Evaluation of Indion CRP-244 and CRP-254 as sustained release and taste masking agents. Indian J. Pharm. Sci. (1981) 43:209-212.
24. YAJIMA T, ITAI S, TAKEUCHI H, KAWASHIMA Y: Optimum heat treatment conditions for masking the bitterness of the clarithromycin wax matrix. Chem. Pharm. Bull. (2003) 51(11):1223-1226.
25. YAJIMA T, UMEKI N, ITAI S: Optimum spray congealing conditions for masking the bitter taste of clarithromycin in wax matrix. Chem. Pharm. Bull. (1999) 47(2):220-225.
26. MCGINITY JW, ZHANG F, REPKA M, KOLENG JJ: Hot-melt extrusion process as a pharmaceutical process. Am. Pharmaceut. Rev. (2001) 4:25-36.