Optimum heat treatment conditions for masking the bitterness of the clarithromycin wax matrix

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 11, 2003, Pages 1223-1226

  Yajima, Toshio ^a   Itai, Shigeru ^a   Takeuchi, Hirofumi ^b   Kawashima, Yoshiaki ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Crystal transformation; Differential scanning calorimeter; Glyceryl monostearate; Spray congealing technique; Transformation rate

Indexed keywords

AMINOALKYL METHACRYLATE COPOLYMER E; CLARITHROMYCIN; GLYCEROL STEARATE; POLYMER; UNCLASSIFIED DRUG; ACYLGLYCEROL; ANTIINFECTIVE AGENT; EXCIPIENT; WAX;

ARTICLE; BITTER TASTE; DRUG MANUFACTURE; DRUG SCREENING; DRUG TRANSFORMATION; ENTHALPY; HEAT TREATMENT; MASKING; TEMPERATURE; THERMAL ANALYSIS; ALGORITHM; CHEMISTRY; CRYSTALLIZATION; DRUG FORMULATION; HEAT; KINETICS; POWDER; TASTE; THERMODYNAMICS; X RAY DIFFRACTION;

ALGORITHMS; ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; CRYSTALLIZATION; DRUG COMPOUNDING; EXCIPIENTS; GLYCERIDES; HEAT; KINETICS; POWDERS; TASTE; THERMODYNAMICS; WAXES; X-RAY DIFFRACTION;

EID: 2942692387     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.1223     Document Type: Article

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