메뉴 건너뛰기




Volumn 34, Issue 8, 2007, Pages 698-708

Altered Gene Expression in Articular Chondrocytes of Smad3ex8/ex8 Mice, Revealed by Gene Profiling Using Microarrays

Author keywords

articular chondrocytes; hypertrophic differentiation; microarray; osteoarthritis; Smad3; TGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GROWTH HORMONE; PROTEIN CDC42; SMAD3 PROTEIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

EID: 34547841637     PISSN: 16738527     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1673-8527(07)60079-4     Document Type: Article
Times cited : (6)

References (35)
  • 1
    • 16244421736 scopus 로고    scopus 로고
    • Transcriptional regulation of chondrocyte maturation: Potential involvement of transcription factors in OA pathogenesis
    • Hicham D., Michael Z., Randy R., and Regis O. Transcriptional regulation of chondrocyte maturation: Potential involvement of transcription factors in OA pathogenesis. Mol Aspects Med 26 (2005) 169-179
    • (2005) Mol Aspects Med , vol.26 , pp. 169-179
    • Hicham, D.1    Michael, Z.2    Randy, R.3    Regis, O.4
  • 2
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Henry M. Developmental regulation of the growth plate. Nature 423 (2003) 332-336
    • (2003) Nature , vol.423 , pp. 332-336
    • Henry, M.1
  • 3
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Gerard K., and Erwin F. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2 (2002) 389-406
    • (2002) Dev Cell , vol.2 , pp. 389-406
    • Gerard, K.1    Erwin, F.2
  • 4
    • 26844502418 scopus 로고    scopus 로고
    • Transcriptional control of chondrocyte fate and differentiation
    • Lefebvre V., and Smits P. Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res C Embryo Today 75 (2005) 200-212
    • (2005) Birth Defects Res C Embryo Today , vol.75 , pp. 200-212
    • Lefebvre, V.1    Smits, P.2
  • 5
    • 0027209267 scopus 로고
    • TGF-β1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases
    • Ballock R. TGF-β1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases. Dev Biol 158 (1993) 414-429
    • (1993) Dev Biol , vol.158 , pp. 414-429
    • Ballock, R.1
  • 6
    • 0027416479 scopus 로고
    • Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serumfree agarose culture
    • Tschan T. Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serumfree agarose culture. J Biol Chem 268 (1993) 5156-5161
    • (1993) J Biol Chem , vol.268 , pp. 5156-5161
    • Tschan, T.1
  • 7
    • 0028284846 scopus 로고
    • Opposite effects of osteogenic protein and transforming growth factor beta on chondrogenesis in cultured long bone rudiments
    • Dieudonne S. Opposite effects of osteogenic protein and transforming growth factor beta on chondrogenesis in cultured long bone rudiments. J Bone Miner Res 9 (1994) 771-780
    • (1994) J Bone Miner Res , vol.9 , pp. 771-780
    • Dieudonne, S.1
  • 8
    • 0028921536 scopus 로고
    • Terminal differentiation of chondrocytes in culture is a spontaneous process and is arrested by transforming growth factor-beta 2 and basic fibroblast growth factor in synergy
    • Bohme K. Terminal differentiation of chondrocytes in culture is a spontaneous process and is arrested by transforming growth factor-beta 2 and basic fibroblast growth factor in synergy. Exp Cell Res 216 (1995) 191-198
    • (1995) Exp Cell Res , vol.216 , pp. 191-198
    • Bohme, K.1
  • 9
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • Serra R. Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol 139 (1997) 541-552
    • (1997) J Cell Biol , vol.139 , pp. 541-552
    • Serra, R.1
  • 10
    • 0037148521 scopus 로고    scopus 로고
    • Bone abnormalities in latent TGF-β binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability
    • Dabovic B. Bone abnormalities in latent TGF-β binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability. J Cell Biol 156 (2002) 227-232
    • (2002) J Cell Biol , vol.156 , pp. 227-232
    • Dabovic, B.1
  • 11
    • 13944259791 scopus 로고    scopus 로고
    • An aspartic acid repreat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to ostesarthtitis
    • Kizawa H. An aspartic acid repreat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to ostesarthtitis. Nature Genet 37 (2005) 138-144
    • (2005) Nature Genet , vol.37 , pp. 138-144
    • Kizawa, H.1
  • 12
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang X., Letterio J., Lechleider R., Chen L., Hayman R., Gu H., Roberts A., and Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J 18 (1999) 1280-1291
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.2    Lechleider, R.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.7    Deng, C.8
  • 13
    • 0035795409 scopus 로고    scopus 로고
    • TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang X., Chen L., Xu X., Li C., Huang C., and Deng C. TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol 153 (2001) 35-46
    • (2001) J Cell Biol , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.6
  • 14
    • 0141701927 scopus 로고    scopus 로고
    • Mutation analysis of the Smad3 gene in human osteoarthritis
    • Yao J. Mutation analysis of the Smad3 gene in human osteoarthritis. Eur J Hum Genet 11 (2003) 714-717
    • (2003) Eur J Hum Genet , vol.11 , pp. 714-717
    • Yao, J.1
  • 15
    • 34547847936 scopus 로고    scopus 로고
    • http://pubmatrix.grc.nia.nih.gov
  • 16
    • 34547836835 scopus 로고    scopus 로고
    • http://www.GenMapp.org
  • 17
    • 34547832842 scopus 로고    scopus 로고
    • http://www.broad.mit.edu/gsea/msigdb/msigdb_index.html
  • 18
    • 0037508734 scopus 로고    scopus 로고
    • Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5
    • Li X., Schwarz E., Zuscik M., Rosier R., Ionescu A., Puzas J., Drissi H., Sheu T., and O'Keefe R. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology 144 (2003) 2514-2523
    • (2003) Endocrinology , vol.144 , pp. 2514-2523
    • Li, X.1    Schwarz, E.2    Zuscik, M.3    Rosier, R.4    Ionescu, A.5    Puzas, J.6    Drissi, H.7    Sheu, T.8    O'Keefe, R.9
  • 20
    • 0034522379 scopus 로고    scopus 로고
    • Smad2 and 3 mediate transforming growth factor-β1-induced inhibition of chondrocyte maturation
    • Cristin M., Edward M., Paul R., J Edward P., Randy N., and Regis J. Smad2 and 3 mediate transforming growth factor-β1-induced inhibition of chondrocyte maturation. Endocrinology 141 (2000) 4728-4735
    • (2000) Endocrinology , vol.141 , pp. 4728-4735
    • Cristin, M.1    Edward, M.2    Paul, R.3    J Edward, P.4    Randy, N.5    Regis, J.6
  • 22
    • 0041569850 scopus 로고    scopus 로고
    • Genetic association analysis of BMP5 as a potential osteoarthritis susceptibility gene
    • Southam L., Chapman K., and Loughlin J. Genetic association analysis of BMP5 as a potential osteoarthritis susceptibility gene. Rheumatology (Oxford) 42 (2003) 911-912
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 911-912
    • Southam, L.1    Chapman, K.2    Loughlin, J.3
  • 24
    • 0036197606 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
    • Edlund S., Landstrom M., Heldin C., and Aspenstrom P. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13 (2002) 902-914
    • (2002) Mol Biol Cell , vol.13 , pp. 902-914
    • Edlund, S.1    Landstrom, M.2    Heldin, C.3    Aspenstrom, P.4
  • 25
    • 0036674213 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration
    • Bakin A., Rinehart C., Tomlinson A., and Arteaga C. p38 mitogen-activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115 (2002) 3193-3206
    • (2002) J Cell Sci , vol.115 , pp. 3193-3206
    • Bakin, A.1    Rinehart, C.2    Tomlinson, A.3    Arteaga, C.4
  • 26
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-b1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick N. Transforming growth factor-b1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12 (2001) 27-36
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.1
  • 27
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-indepen dent pathways in TGF-β family signaling
    • Derynck R., and Zhang Y. Smad-dependent and Smad-indepen dent pathways in TGF-β family signaling. Nature 425 (2003) 577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.2
  • 28
    • 19044390915 scopus 로고    scopus 로고
    • Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis
    • Wang G., and Beier F. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J Bone Miner Res 20 (2005) 1022-1031
    • (2005) J Bone Miner Res , vol.20 , pp. 1022-1031
    • Wang, G.1    Beier, F.2
  • 29
    • 0030589726 scopus 로고    scopus 로고
    • Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2
    • Tsukiyama-Kohara K., Vidal S., Gingras A., Glover T., Hanash S., Heng H., and Sonenberg N. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics 38 (1996) 353-363
    • (1996) Genomics , vol.38 , pp. 353-363
    • Tsukiyama-Kohara, K.1    Vidal, S.2    Gingras, A.3    Glover, T.4    Hanash, S.5    Heng, H.6    Sonenberg, N.7
  • 30
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause A., Belsham G., Gingras A., Donze O., Lin T., Lawrence Jr. J., and Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371 (1994) 762-767
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.2    Gingras, A.3    Donze, O.4    Lin, T.5    Lawrence Jr., J.6    Sonenberg, N.7
  • 31
    • 0028126506 scopus 로고
    • PHAS-I as a link between mitogen-activated protein kinase and translation initiation
    • Lin T., Kong X., Haystead T., Pause A., Belsham G., Sonenberg N., and Lawrence Jr. J. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266 (1994) 653-656
    • (1994) Science , vol.266 , pp. 653-656
    • Lin, T.1    Kong, X.2    Haystead, T.3    Pause, A.4    Belsham, G.5    Sonenberg, N.6    Lawrence Jr., J.7
  • 32
    • 0035527326 scopus 로고    scopus 로고
    • Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins
    • Clemens M. Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins. J Cell Mol Med 5 (2001) 221-239
    • (2001) J Cell Mol Med , vol.5 , pp. 221-239
    • Clemens, M.1
  • 33
    • 0018111585 scopus 로고
    • Chondrocytes
    • (R Coll Path)
    • Stockwell R. Chondrocytes. J Clin Path 12 31, Suppl (1978) 7-13 (R Coll Path)
    • (1978) J Clin Path , vol.12 , Issue.31 SUPPL , pp. 7-13
    • Stockwell, R.1
  • 34
    • 0141504018 scopus 로고    scopus 로고
    • The role of reactive oxygen species in homeostasis and degradation of cartilage
    • Henrotin Y., Bruckner P., and Pujol J. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11 (2003) 747-755
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 747-755
    • Henrotin, Y.1    Bruckner, P.2    Pujol, J.3
  • 35


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.