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Volumn 30, Issue 6, 2007, Pages 624-633

IRX-2, a novel in vivo immunotherapeutic, induces maturation and activation of human dendritic cells in vitro

Author keywords

Cancer; Cytokines; Dendritic cells; Head and neck squamous cell carcinoma; Immunotherapy; IRX 2

Indexed keywords

CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; IRX 2; UNCLASSIFIED DRUG;

EID: 34547769186     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3180691593     Document Type: Article
Times cited : (34)

References (56)
  • 3
    • 4944223122 scopus 로고    scopus 로고
    • Manipulating dendritic cell biology for the active immunotherapy of cancer
    • O'Neill DW, Adams S, Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood. 2004;104:2235-2246.
    • (2004) Blood , vol.104 , pp. 2235-2246
    • O'Neill, D.W.1    Adams, S.2    Bhardwaj, N.3
  • 4
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol. 2004;4:941-952.
    • (2004) Nat Rev Immunol , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 5
    • 29444456934 scopus 로고    scopus 로고
    • Human dendritic cell subsets for vaccination
    • Dubsky P, Ueno H, Piqueras B, et al. Human dendritic cell subsets for vaccination. J Clin Immunol. 2005;25:551-572.
    • (2005) J Clin Immunol , vol.25 , pp. 551-572
    • Dubsky, P.1    Ueno, H.2    Piqueras, B.3
  • 6
    • 1242300056 scopus 로고    scopus 로고
    • Dendritic cells: Friend or foe in autoimmunity?
    • Santiago-Schwarz F. Dendritic cells: friend or foe in autoimmunity? Rheum Dis Clin North Am. 2004;30:115-134.
    • (2004) Rheum Dis Clin North Am , vol.30 , pp. 115-134
    • Santiago-Schwarz, F.1
  • 7
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994;179:1109-1118.
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 8
    • 0029961746 scopus 로고    scopus 로고
    • CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells
    • Zhou LJ, Tedder TF. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA. 1996;93:2588-2592.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2588-2592
    • Zhou, L.J.1    Tedder, T.F.2
  • 9
    • 0030858138 scopus 로고    scopus 로고
    • Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
    • Cella M, Engering A, Pinet V, et al. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 1997;388:782-787.
    • (1997) Nature , vol.388 , pp. 782-787
    • Cella, M.1    Engering, A.2    Pinet, V.3
  • 10
    • 0036607954 scopus 로고    scopus 로고
    • CD83 on dendritic cells: More than just a marker for maturation
    • Lechmann M, Berchtold S, Hauber J, et al. CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 2002;23:273-275.
    • (2002) Trends Immunol , vol.23 , pp. 273-275
    • Lechmann, M.1    Berchtold, S.2    Hauber, J.3
  • 11
    • 0031712324 scopus 로고    scopus 로고
    • Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
    • Sallusto F, Schaerli P, Loetscher P, et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol. 1998;28:2760-2769.
    • (1998) Eur J Immunol , vol.28 , pp. 2760-2769
    • Sallusto, F.1    Schaerli, P.2    Loetscher, P.3
  • 12
    • 0037103261 scopus 로고    scopus 로고
    • Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: Prostaglandin E(2) regulates the migratory capacity of specific DC subsets
    • Luft T, Jefford M, Luetjens P, et al. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood. 2002;100:1362-1372.
    • (2002) Blood , vol.100 , pp. 1362-1372
    • Luft, T.1    Jefford, M.2    Luetjens, P.3
  • 13
    • 0037103366 scopus 로고    scopus 로고
    • Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells
    • Scandella E, Men Y, Gillessen S, et al. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood. 2002;100:1354-1361.
    • (2002) Blood , vol.100 , pp. 1354-1361
    • Scandella, E.1    Men, Y.2    Gillessen, S.3
  • 14
    • 0034891344 scopus 로고    scopus 로고
    • Dendritic cell migration to lymph nodes: Cytokines, chemokines, and lipid mediators
    • Randolph GJ. Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators. Semin Immunol. 2001;13:267-274.
    • (2001) Semin Immunol , vol.13 , pp. 267-274
    • Randolph, G.J.1
  • 15
    • 0032134302 scopus 로고    scopus 로고
    • Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties
    • Sozzani S, Allavena P, D'Amico G, et al. Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J Immunol. 1998;161:1083-1086.
    • (1998) J Immunol , vol.161 , pp. 1083-1086
    • Sozzani, S.1    Allavena, P.2    D'Amico, G.3
  • 16
    • 0642311904 scopus 로고    scopus 로고
    • Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells
    • Slingluff CL Jr, Petroni GR, Yamshchikov GV, et al. Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells. J Clin Oncol. 2003;21:4016-4026.
    • (2003) J Clin Oncol , vol.21 , pp. 4016-4026
    • Slingluff Jr, C.L.1    Petroni, G.R.2    Yamshchikov, G.V.3
  • 17
    • 10744224631 scopus 로고    scopus 로고
    • Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients
    • de Vries IJ, Lesterhuis WJ, Scharenborg NM, et al. Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients. Clin Cancer Res. 2003;9:5091-5100.
    • (2003) Clin Cancer Res , vol.9 , pp. 5091-5100
    • de Vries, I.J.1    Lesterhuis, W.J.2    Scharenborg, N.M.3
  • 18
    • 0035879893 scopus 로고    scopus 로고
    • A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection
    • Jonuleit H, Giesecke-Tuettenberg A, Tuting T, et al. A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection. Int J Cancer. 2001;93:243-251.
    • (2001) Int J Cancer , vol.93 , pp. 243-251
    • Jonuleit, H.1    Giesecke-Tuettenberg, A.2    Tuting, T.3
  • 19
    • 0035862333 scopus 로고    scopus 로고
    • Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • Dhodapkar MV, Steinman RM, Krasovsky J, et al. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med. 2001;193:233-238.
    • (2001) J Exp Med , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3
  • 20
    • 0037141023 scopus 로고    scopus 로고
    • Rapid induction of tumor-specific type 1T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells
    • Schuler-Thurner B, Schultz ES, Berger TG, et al. Rapid induction of tumor-specific type 1T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells. J Exp Med. 2002;195:1279-1288.
    • (2002) J Exp Med , vol.195 , pp. 1279-1288
    • Schuler-Thurner, B.1    Schultz, E.S.2    Berger, T.G.3
  • 21
    • 0034125451 scopus 로고    scopus 로고
    • Clinical significance of defective dendritic cell differentiation in cancer
    • Almand B, Resser JR, Lindman B, et al. Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res. 2000;6:1755-1766.
    • (2000) Clin Cancer Res , vol.6 , pp. 1755-1766
    • Almand, B.1    Resser, J.R.2    Lindman, B.3
  • 22
    • 0030934973 scopus 로고    scopus 로고
    • Decreased antigen presentation by dendritic cells in patients with breast cancer
    • Gabrilovich DI, Corak J, Ciernik IF, et al. Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res. 1997;3:483-490.
    • (1997) Clin Cancer Res , vol.3 , pp. 483-490
    • Gabrilovich, D.I.1    Corak, J.2    Ciernik, I.F.3
  • 23
    • 0029937941 scopus 로고    scopus 로고
    • Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation
    • Chaux P, Moutet M, Faivre J, et al. Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation. Lab Invest. 1996;74:975-983.
    • (1996) Lab Invest , vol.74 , pp. 975-983
    • Chaux, P.1    Moutet, M.2    Faivre, J.3
  • 24
    • 0036278521 scopus 로고    scopus 로고
    • Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck
    • Hoffmann TK, Muller-Berghaus J, Ferris RL, et al. Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. Clin Cancer Res. 2002;8:1787-1793.
    • (2002) Clin Cancer Res , vol.8 , pp. 1787-1793
    • Hoffmann, T.K.1    Muller-Berghaus, J.2    Ferris, R.L.3
  • 25
    • 0029903790 scopus 로고    scopus 로고
    • Human renal-cell carcinoma tissue contains dendritic cells
    • Thurnher M, Radmayr C, Ramoner R, et al. Human renal-cell carcinoma tissue contains dendritic cells. Int J Cancer. 1996;68:1-7.
    • (1996) Int J Cancer , vol.68 , pp. 1-7
    • Thurnher, M.1    Radmayr, C.2    Ramoner, R.3
  • 26
    • 3242798756 scopus 로고    scopus 로고
    • Antigen-processing machinery in human dendritic cells: Up-regulation by maturation and down-regulation by tumor cells
    • Whiteside TL, Stanson J, Shurin MR, et al. Antigen-processing machinery in human dendritic cells: up-regulation by maturation and down-regulation by tumor cells. J Immunol. 2004;173:1526-1534.
    • (2004) J Immunol , vol.173 , pp. 1526-1534
    • Whiteside, T.L.1    Stanson, J.2    Shurin, M.R.3
  • 27
    • 0035164478 scopus 로고    scopus 로고
    • Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
    • Almand B, Clark JI, Nikitina E, et al. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol. 2001;166:678-689.
    • (2001) J Immunol , vol.166 , pp. 678-689
    • Almand, B.1    Clark, J.I.2    Nikitina, E.3
  • 28
    • 0037632264 scopus 로고    scopus 로고
    • A trial of IRX-2 in patients with squamous cell carcinomas of the head and neck
    • Hadden J, Verastegui E, Barrera JL, et al. A trial of IRX-2 in patients with squamous cell carcinomas of the head and neck. Int Immunopharmacol. 2003;3:1073-1081.
    • (2003) Int Immunopharmacol , vol.3 , pp. 1073-1081
    • Hadden, J.1    Verastegui, E.2    Barrera, J.L.3
  • 29
    • 0033430318 scopus 로고    scopus 로고
    • Sinus histiocytosis with massive lymphadenopathy: Evidence for its relationship to macrophages and for a cytokine-related disorder
    • Middel P, Hemmerlein B, Fayyazi A, et al. Sinus histiocytosis with massive lymphadenopathy: evidence for its relationship to macrophages and for a cytokine-related disorder. Histopathology. 1999;35:525-533.
    • (1999) Histopathology , vol.35 , pp. 525-533
    • Middel, P.1    Hemmerlein, B.2    Fayyazi, A.3
  • 30
    • 0037632262 scopus 로고    scopus 로고
    • Lymph node histology in head and neck cancer: Impact of immunotherapy with IRX-2
    • Meneses A, Verastegui E, Barrera JL, et al. Lymph node histology in head and neck cancer: impact of immunotherapy with IRX-2. Int Immunopharmacol. 2003;3:1083-1091.
    • (2003) Int Immunopharmacol , vol.3 , pp. 1083-1091
    • Meneses, A.1    Verastegui, E.2    Barrera, J.L.3
  • 31
    • 0042889317 scopus 로고    scopus 로고
    • TNF skews monocyte differentiation from macrophages to dendritic cells
    • Chomarat P, Dantin C, Bennett L, et al. TNF skews monocyte differentiation from macrophages to dendritic cells. J Immunol. 2003;171:2262-2269.
    • (2003) J Immunol , vol.171 , pp. 2262-2269
    • Chomarat, P.1    Dantin, C.2    Bennett, L.3
  • 32
    • 0037137573 scopus 로고    scopus 로고
    • A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: Implications for immunotherapy
    • Lee AW, Truong T, Bickham K, et al. A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy. Vaccine. 2002;20(suppl 4):A8-A22.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 4
    • Lee, A.W.1    Truong, T.2    Bickham, K.3
  • 33
    • 0030833496 scopus 로고    scopus 로고
    • A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells
    • Reddy A, Sapp M, Feldman M, et al. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood. 1997;90:3640-3646.
    • (1997) Blood , vol.90 , pp. 3640-3646
    • Reddy, A.1    Sapp, M.2    Feldman, M.3
  • 34
    • 0034655262 scopus 로고    scopus 로고
    • CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes
    • Hirao M, Onai N, Hiroishi K, et al. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes. Cancer Res. 2000;60:2209-2217.
    • (2000) Cancer Res , vol.60 , pp. 2209-2217
    • Hirao, M.1    Onai, N.2    Hiroishi, K.3
  • 35
    • 0029148878 scopus 로고
    • Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
    • Sallusto F, Cella M, Danieli C, et al. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995;182:389-400.
    • (1995) J Exp Med , vol.182 , pp. 389-400
    • Sallusto, F.1    Cella, M.2    Danieli, C.3
  • 36
    • 0028867537 scopus 로고
    • Immunotherapy with natural interleukins and/or thymosin alpha 1 potently augments T-lymphocyte responses of hydrocortisone-treated aged mice
    • Hadden JW, Saha A, Sosa M, et al. Immunotherapy with natural interleukins and/or thymosin alpha 1 potently augments T-lymphocyte responses of hydrocortisone-treated aged mice. Int J Immunopharmacol. 1995;17:821-828.
    • (1995) Int J Immunopharmacol , vol.17 , pp. 821-828
    • Hadden, J.W.1    Saha, A.2    Sosa, M.3
  • 37
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003;3:133-146.
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 38
    • 0035905461 scopus 로고    scopus 로고
    • The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells
    • Lechmann M, Krooshoop DJ, Dudziak D, et al. The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J Exp Med. 2001;194:1813-1821.
    • (2001) J Exp Med , vol.194 , pp. 1813-1821
    • Lechmann, M.1    Krooshoop, D.J.2    Dudziak, D.3
  • 39
    • 0033658153 scopus 로고    scopus 로고
    • Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
    • Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev. 2000;177:134-140.
    • (2000) Immunol Rev , vol.177 , pp. 134-140
    • Sallusto, F.1    Lanzavecchia, A.2
  • 40
    • 0034767717 scopus 로고    scopus 로고
    • Standardized generation of fully mature p70 IL-12 secreting monocyte-derived dendritic cells for clinical use
    • Spisek R, Bretaudeau L, Barbieux I, et al. Standardized generation of fully mature p70 IL-12 secreting monocyte-derived dendritic cells for clinical use. Cancer Immunol Immunother. 2001;50:417-427.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 417-427
    • Spisek, R.1    Bretaudeau, L.2    Barbieux, I.3
  • 41
    • 0035383783 scopus 로고    scopus 로고
    • Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
    • Kalinski P, Vieira PL, Schuitemaker JH, et al. Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood. 2001;97:3466-3469.
    • (2001) Blood , vol.97 , pp. 3466-3469
    • Kalinski, P.1    Vieira, P.L.2    Schuitemaker, J.H.3
  • 42
    • 24144495503 scopus 로고    scopus 로고
    • Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: The importance of maturation cocktails
    • Jongmans W, Tiemessen DM, van Vlodrop IJ, et al. Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: the importance of maturation cocktails. J Immunother. 2005;28:480-487.
    • (2005) J Immunother , vol.28 , pp. 480-487
    • Jongmans, W.1    Tiemessen, D.M.2    van Vlodrop, I.J.3
  • 43
    • 0034654529 scopus 로고    scopus 로고
    • CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen
    • Rogers PR, Croft M. CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J Immunol. 2000;164:2955-2963.
    • (2000) J Immunol , vol.164 , pp. 2955-2963
    • Rogers, P.R.1    Croft, M.2
  • 44
    • 0030603987 scopus 로고    scopus 로고
    • Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability
    • Romani N, Reider D, Heuer M, et al. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods. 1996;196:137-151.
    • (1996) J Immunol Methods , vol.196 , pp. 137-151
    • Romani, N.1    Reider, D.2    Heuer, M.3
  • 45
    • 0030603986 scopus 로고    scopus 로고
    • Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
    • Bender A, Sapp M, Schuler G, et al. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods. 1996;196:121-135.
    • (1996) J Immunol Methods , vol.196 , pp. 121-135
    • Bender, A.1    Sapp, M.2    Schuler, G.3
  • 46
    • 0037491839 scopus 로고    scopus 로고
    • Clinical-scale generation of dendritic cells in a closed system
    • Sorg RV, Ozcan Z, Brefort T, et al. Clinical-scale generation of dendritic cells in a closed system. J Immunother. 2003;26:374-383.
    • (2003) J Immunother , vol.26 , pp. 374-383
    • Sorg, R.V.1    Ozcan, Z.2    Brefort, T.3
  • 47
    • 0037039379 scopus 로고    scopus 로고
    • Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
    • Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A. 2002;99:351-358.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 351-358
    • Steinman, R.M.1    Nussenzweig, M.C.2
  • 48
    • 0034305809 scopus 로고    scopus 로고
    • Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells
    • Langenkamp A, Messi M, Lanzavecchia A, et al. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol. 2000;1:311-316.
    • (2000) Nat Immunol , vol.1 , pp. 311-316
    • Langenkamp, A.1    Messi, M.2    Lanzavecchia, A.3
  • 49
    • 0038079749 scopus 로고    scopus 로고
    • Critical impact of the kinetics of dendritic cells activation on the in vivo induction of tumorspecific T lymphocytes
    • Camporeale A, Boni A, Iezzi G, et al. Critical impact of the kinetics of dendritic cells activation on the in vivo induction of tumorspecific T lymphocytes. Cancer Res. 2003;63:3688-3694.
    • (2003) Cancer Res , vol.63 , pp. 3688-3694
    • Camporeale, A.1    Boni, A.2    Iezzi, G.3
  • 50
    • 0345346375 scopus 로고    scopus 로고
    • Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    • Kalinski P, Schuitemaker JH, Hilkens CM, et al. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol. 1999;162:3231-3236.
    • (1999) J Immunol , vol.162 , pp. 3231-3236
    • Kalinski, P.1    Schuitemaker, J.H.2    Hilkens, C.M.3
  • 51
    • 0036845714 scopus 로고    scopus 로고
    • Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells
    • Holtl L, Zelle-Rieser C, Gander H, et al. Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin Cancer Res. 2002;8:3369-3376.
    • (2002) Clin Cancer Res , vol.8 , pp. 3369-3376
    • Holtl, L.1    Zelle-Rieser, C.2    Gander, H.3
  • 52
    • 0346096827 scopus 로고    scopus 로고
    • The first 1000 dendritic cell vaccinees
    • Ridgway D. The first 1000 dendritic cell vaccinees. Cancer Invest. 2003;21:873-886.
    • (2003) Cancer Invest , vol.21 , pp. 873-886
    • Ridgway, D.1
  • 53
    • 0037137530 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines based on molecularly defined human tumor antigens
    • Romero P, Pittet M, Dutoit V, et al. Therapeutic cancer vaccines based on molecularly defined human tumor antigens. Vaccine. 2002;20(suppl 4):A2-A7.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 4
    • Romero, P.1    Pittet, M.2    Dutoit, V.3
  • 54
    • 0037443473 scopus 로고    scopus 로고
    • Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo
    • Kleindienst P, Brocker T. Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. J Immunol. 2003;170:2817-2823.
    • (2003) J Immunol , vol.170 , pp. 2817-2823
    • Kleindienst, P.1    Brocker, T.2
  • 55
    • 4644364500 scopus 로고    scopus 로고
    • Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo
    • Lou Y, Wang G, Lizee G, et al. Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo. Cancer Res. 2004;64:6783-6790.
    • (2004) Cancer Res , vol.64 , pp. 6783-6790
    • Lou, Y.1    Wang, G.2    Lizee, G.3
  • 56
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909-915.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.