A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: Implications for immunotherapy

Vaccine

Volumn 20, Issue SUPPL. 4, 2002, Pages

  Lee, Andrew W ^a   Truong, Tuan ^a   Bickham, Kara ^a   Fonteneau, Jean Francois ^a   Larsson, Marie ^a   Da Silva, Ida ^a   Somersan, Selin ^a   Thomas, Elaine K ^b   Bhardwaj, Nina ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b AMGEN INC   (United States)

Author keywords

Dendritic cells; Immunotherapy; T cell activation; Vaccination

Indexed keywords

ALLOANTIGEN; B7 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOKINE; DOUBLE STRANDED RNA; GAMMA INTERFERON; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; LIGAND; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOKINE; POLYCYTIDYLIC ACID; POLYINOSINIC ACID; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; LEUKOCYTE; LYMPHOCYTE CLONE; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; T LYMPHOCYTE; ARTICLE; CELL DIVISION; CULTURE MEDIUM; CYTOLOGY; IMMUNOLOGY; METABOLISM; MIXED LYMPHOCYTE CULTURE; SECRETION;

CELL DIVISION; CULTURE MEDIA, CONDITIONED; CYTOKINES; DENDRITIC CELLS; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOTHERAPY; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOCYTE CULTURE TEST, MIXED; MONOCYTES;

EID: 0037137573     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00382-1     Document Type: Conference Paper

References (47)

1. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245.
2. Panelli M.C., Wunderlich J., Jeffries J.et al. Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. J. Immunother. 23:2000;487.
3. Thurner B., Haendle I., Röder C.et al. Vaccination with Mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J. Exp. Med. 190:1999;1669.
4. Schuler-Thurner B., Dieckmann D., Keikavoussi P.et al. Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells. J. Immunol. 165:2000;3492.
5. Fong L., Engleman E.G. Dendritic cells in cancer immunotherapy. Annu. Rev. Immunol. 18:2000;245.
6. Reddy A., Sapp M., Feldman M., Subklewe M., Bhardwaj N. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood. 90:1997;3640.
7. + T helper and a T-killer cell. Nature. 393:1998;474.
8. Bennett S.R.M., Carbone F.R., Karamalis F., Flavell R.A., Miller J.F.A.P., Heath W.R. Help for cytotoxic T cell responses is mediated by CD40 signalling. Nature. 393:1998;478.
9. Schoenberger S.P., Toes R.E.M., van der Voort E.I.H., Offringa R., Melief C.J.M. T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393:1998;480.
10. Cella M., Salio M., Sakakibara Y., Langen H., Julkunen I., Lanzavecchia A. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med. 189:1999;821.
11. Strayer D.R., Carter W.A., Brodsky I.et al. A controlled clinical trial with a specifically configured RNA drug, poly(I):poly(C) 12 U, in chronic fatigue syndrome. Clin. Infect. Dis. 18(Suppl 1):1994;S88.
12. Jonuleit H., Kuhn U., Muller G.et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27:1997;3135.
13. + T cells. J. Immunol. 165:2000;1182.
14. + T cells with regulatory properties by repetitive stimulation with allogeneic immature dendritic cells. J. Exp. Med. 192:2000;1213.
15. Labeur M.S., Roters B., Pers B., Mehling A., Luger T.A., Schwarz T.et al. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage. J. Immunol. 162:1999;168.
16. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigen specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193:2001;233.
17. Dhodapkar M., Steinman R.M., Sapp M.et al. Rapid generation of broad T cell immunity in humans after single injection of mature dendritic cells. J. Clin. Invest. 104:1999;173.
18. + T cell clones using peptide pulsed mature dendritic cells. J. Immunol. Methods. 258:2001;111.
19. + T cells in chronically infected HIV-1-positive individuals. AIDS. 13:1999;767.
20. Hochrein H., O'Keeffe M., Luft T.et al. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J. Exp. Med. 192:2000;823.
21. Cella M., Scheidegger D., Palmer-Lehmann K., Lane P., Lanzavecchia A., Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:1996;747.
22. Moser M., Murphy K.M. Dendritic cell regulation of Th1-Th2 development. Nat. Immunol. 1:2000;199.
23. 2 is a selective inducer of interleukin-12p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood. 97:2001;3466.
24. Mehlhop E., Villamide L.A., Frank I.et al. Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses. J. Immunol. Methods. 260:2002;219.
25. Schuler-Thurner B., Schultz E.S., Berger T.G.et al. Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells. J. Exp. Med. 195:2002;1279.
26. Steinbrink K., Paragnik L., Jonuleit H., Tuting T., Knop J., Enk A.H. Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins. Arch. Dermatol. Res. 292:2000;437.
27. Thurner B., Röder C., Dieckmann D.et al. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J. Immunol. Methods. 223:1999;1.
28. Verdijk R.M., Mutis T., Esendam B., Kamp J., Melief C.J., Brand A.et al. Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells. J. Immunol. 163:1999;57.
29. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF-α Adv. Exp. Med. Biol. 417:1997;21.
30. + dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J. Immunol. 161:1998;2804.
31. Lin C.-L., Suri R.M., Rahdon R.A., Austyn J.M., Roake J.A. Dendritic cell chemotaxis and transedothelial migration are induced by distinct chemokines and are regulated on maturation. Eur. J. Immunol. 28:1998;4114.
32. + dendritic cells and is up-regulated by IL-1β J. Immunol. 167:2001;1989.
33. Tseng S.Y., Otsugi M., Gorski K.et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193:2001;839.
34. Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. Regulation of the interleukin (IL)-12R b2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:1997;817.
35. Ebner S., Ratzinger G., Krosbacher B.et al. Production of interleukin-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by interleukin, and is further enhanced by interleukin-4. J. Immunol. 166:2001;633.
36. Snijders A., Kalinski P., Hilkens C.M., Kapsenberg M.L. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10:1998;1593.
37. Gorak P.M.A., Engwerda C.R., Kaye P.M. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur. J. Immunol. 28:1998;687.
38. Reis e Sousa C., Hieny S., Scharton-Kersten T.et al. In vivo microbial stimulation induces rapid CD40L-independent production of IL-12 by dendritic cells and their re-distribution to T cell areas. J. Exp. Med. 186:1997;1819.
39. d'Ostiani C.F., Del Sero G., Bacci A.et al. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. 191:2000;1661.
40. + dendritic cells. Nat. Immunol. 1:2000;83.
41. Wong D.K.H., Dudley D.D., Afdhal N.H.et al. Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J. Immunol. 160:1998;1479.
42. Kalinski P., Schuitemaker J.H., Hilkens C.M., Wierenga E.A., Kapsenberg M.L. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J. Immunol. 162:1999;3231.
43. 2 enhances the production of endogenous IL-10, which down regulates dendritic cell functions. J. Immunol. 168:2002;1263.
44. Mosca P.J., Hobeika A.C., Clay T.M.et al. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood. 96:2000;3499.
45. Foster G.R., Germain C., Jones M., Lechler R.I., Lombardi G. Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions. Eur. J. Immunol. 30:2000;3228.
46. Vieira P.L., de Jong E.C., Wierenga E.A., Kapsenberg M.L., Kalinski P. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J. Immunol. 164:2000;4507.
47. + CTL in vivo. J. Immunol. 167:2001;5027.