Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-κB in cultured Caco-2 cells

Journal of Cellular Biochemistry

Volumn 91, Issue 5, 2004, Pages 951-961

  Hershko, Dan D ^a   Robb, Bruce W ^b   Wray, Curtis J ^b   Luo, Guan Ju ^a   Hasselgren, Per Olof ^c,d  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cell signaling; Cytokines; Enterocytes; Protein synthesis inhibitors; Transcription factors

Indexed keywords

CYCLOHEXIMIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; SB 208350; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; DACTINOMYCIN; FLAVONOID; I KAPPA B; IMIDAZOLE DERIVATIVE; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PYRIDINE DERIVATIVE;

ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RNA STABILITY; DRUG ANTAGONISM; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CACO-2 CELLS; CYCLOHEXIMIDE; DACTINOMYCIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B PROTEINS; IMIDAZOLES; INTERLEUKIN-1; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 16644383740     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20014     Document Type: Article

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