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Volumn 17, Issue 2, 2003, Pages 117-126

Inhibition of human cholinesterases by drugs used to treat Alzheimer disease

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase inhibitors

Indexed keywords

ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ARYL ACYLAMIDASE; BUTYRYLTHIOCHOLINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; ESTERASE; GALANTAMINE; METRIFONATE; NEUROTRANSMITTER; PHYSOSTIGMINE; RIVASTIGMINE; TACRINE;

EID: 0038308812     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-200304000-00011     Document Type: Article
Times cited : (139)

References (56)
  • 1
    • 0034685887 scopus 로고    scopus 로고
    • Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity
    • Alhomida AS, Al-Rajhi AA, Kamal MA, et al. Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity. Toxicology 2000;147:33-9.
    • (2000) Toxicology , vol.147 , pp. 33-39
    • Alhomida, A.S.1    Al-Rajhi, A.A.2    Kamal, M.A.3
  • 2
    • 0036363671 scopus 로고    scopus 로고
    • Advances in the treatment of Alzheimer's disease: Benefits of dual cholinesterase inhibition
    • Ballard CG. Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition. Eur Neurol 2002;47:64-70.
    • (2002) Eur Neurol , vol.47 , pp. 64-70
    • Ballard, C.G.1
  • 3
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RLI, Beer B, et al. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;217:408-17.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.I.2    Beer, B.3
  • 4
    • 0026504115 scopus 로고
    • Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase
    • Berman HA, Leonard K. Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. Mol Pharmacol 1992;41:412-8.
    • (1992) Mol Pharmacol , vol.41 , pp. 412-418
    • Berman, H.A.1    Leonard, K.2
  • 5
    • 0032926540 scopus 로고    scopus 로고
    • Donepezil in the treatment of Alzheimer's disease: Results from a multinational clinical trial
    • Burns A, Rossor M, Hecker J, et al. Donepezil in the treatment of Alzheimer's disease: results from a multinational clinical trial. Dement Geriatr Cogn Disord 1999;10:237-44.
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 237-244
    • Burns, A.1    Rossor, M.2    Hecker, J.3
  • 7
    • 0031902795 scopus 로고    scopus 로고
    • A randomised trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderate severe Alzheimer's disease
    • Corey-Bloom J, Anand R, Veach J et al. A randomised trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderate severe Alzheimer's disease. Int J Geriatr Psychiatry 1998;1:55-65.
    • (1998) Int J Geriatr Psychiatry , vol.1 , pp. 55-65
    • Corey-Bloom, J.1    Anand, R.2    Veach, J.3
  • 8
    • 0032524964 scopus 로고    scopus 로고
    • Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: Focus on drugs potentially effective in Alzheimer's disease
    • Costagli C, Galli A. Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease. Biochem Pharmacol 1998; 55:1733-7.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1733-1737
    • Costagli, C.1    Galli, A.2
  • 9
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, DeLong MR. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 1983;219:1184-90.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 10
    • 0031842292 scopus 로고    scopus 로고
    • Metrifonate treatment of the cognitive deficits of Alzheimer's disease: Metrifonate Study Group
    • Cummings JL, Cyrus PA, Bieber F, et al. Metrifonate treatment of the cognitive deficits of Alzheimer's disease: Metrifonate Study Group. Neurology 1998;50:1214-21.
    • (1998) Neurology , vol.50 , pp. 1214-1221
    • Cummings, J.L.1    Cyrus, P.A.2    Bieber, F.3
  • 11
    • 0032513557 scopus 로고    scopus 로고
    • Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation
    • Darvesh S, Grantham DL, Hopkins DA. Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation. J Comp Neurol 1998a;393:374-90.
    • (1998) J Comp Neurol , vol.393 , pp. 374-390
    • Darvesh, S.1    Grantham, D.L.2    Hopkins, D.A.3
  • 12
    • 0034850214 scopus 로고    scopus 로고
    • Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin
    • Darvesh S, Kumar R, Roberts S, et al. Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin. Cell Mol Neurobiol 2001a;21:285-9.
    • (2001) Cell Mol Neurobiol , vol.21 , pp. 285-289
    • Darvesh, S.1    Kumar, R.2    Roberts, S.3
  • 13
    • 0037951616 scopus 로고    scopus 로고
    • Enzyme kinetic properties of cholinesterase inhibitors used to treat Alzheimer's disease
    • Darvesh S, Kumar R, Caines A, et al. Enzyme kinetic properties of cholinesterase inhibitors used to treat Alzheimer's disease. Can J Neurol Sci 2001b;28(suppl):34.
    • (2001) Can J Neurol Sci , vol.28 , Issue.SUPPL. , pp. 34
    • Darvesh, S.1    Kumar, R.2    Caines, A.3
  • 14
    • 0032527453 scopus 로고    scopus 로고
    • Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity
    • Darvesh S, MacDonald SE, Losier AM, et al. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. J Auton Nerv Syst 1998b;71:75-84.
    • (1998) J Auton Nerv Syst , vol.71 , pp. 75-84
    • Darvesh, S.1    MacDonald, S.E.2    Losier, A.M.3
  • 15
    • 0026756286 scopus 로고
    • A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease: The Tacrine Collaborative Study Group
    • Davis KL, Thai LJ, Gamzu ER, et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease: the Tacrine Collaborative Study Group. N Engl J Med 1992;327:1253-9.
    • (1992) N Engl J Med , vol.327 , pp. 1253-1259
    • Davis, K.L.1    Thai, L.J.2    Gamzu, E.R.3
  • 16
    • 33644811612 scopus 로고
    • A new and rapid colorimetric determination of acetylcholinesterase activity
    • Ellman GL, Courtney KD, Andres VJ, et al. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88-95.
    • (1961) Biochem Pharmacol , vol.7 , pp. 88-95
    • Ellman, G.L.1    Courtney, K.D.2    Andres, V.J.3
  • 17
    • 0027429837 scopus 로고
    • Brain selective inhibition of acetylcholinesterase: A novel approach to therapy for Alzheimer's disease
    • Enz A, Amstutz R, Boddeke H, et al. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease. Prog Brain Res 1993;98:431-8.
    • (1993) Prog Brain Res , vol.98 , pp. 431-438
    • Enz, A.1    Amstutz, R.2    Boddeke, H.3
  • 18
    • 0017149229 scopus 로고
    • Serotonin-sensitive aryl acylamidase activity of acetylcholinesterase
    • Fujimoto D. Serotonin-sensitive aryl acylamidase activity of acetylcholinesterase. FEBS Lett 1976;71:121-3.
    • (1976) FEBS Lett , vol.71 , pp. 121-123
    • Fujimoto, D.1
  • 19
    • 0019768441 scopus 로고
    • The aryl acylamidases and their relationship to cholinesterases in human serum, erythrocyte and liver
    • George ST, Balasubramanian AS. The aryl acylamidases and their relationship to cholinesterases in human serum, erythrocyte and liver. Eur J Biochem 1982;121:177-86.
    • (1982) Eur J Biochem , vol.121 , pp. 177-186
    • George, S.T.1    Balasubramanian, A.S.2
  • 20
    • 0030763602 scopus 로고    scopus 로고
    • From molecular structure to Alzheimer therapy
    • Giacobini E. From molecular structure to Alzheimer therapy. Jpn J Pharmacol 1997;74:225-41.
    • (1997) Jpn J Pharmacol , vol.74 , pp. 225-241
    • Giacobini, E.1
  • 21
    • 0001885399 scopus 로고    scopus 로고
    • Cholinesterase inhibitors: From the Calabar bean to Alzheimer therapy
    • Giacobini E, ed. London: Martin Dunitz
    • Giacobini E. Cholinesterase inhibitors: from the Calabar bean to Alzheimer therapy. In: Giacobini E, ed. Cholinesterases and Cholinesterase Inhibitors. London: Martin Dunitz, 2000:181-226.
    • (2000) Cholinesterases and Cholinesterase Inhibitors , pp. 181-226
    • Giacobini, E.1
  • 22
    • 0035727527 scopus 로고    scopus 로고
    • Selective inhibitors of butyrylcholinesterase: A valid alternative for therapy of Alzheimer's disease?
    • Giacobini E. Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease? Drugs Aging 2001;18: 891-8.
    • (2001) Drugs Aging , vol.18 , pp. 891-898
    • Giacobini, E.1
  • 23
    • 0035661483 scopus 로고    scopus 로고
    • A new therapeutic target in Alzheimer's disease: Attention to butyrylcholinesterase
    • Greig NH, Utsuki T, Yu Q-S, et al. A new therapeutic target in Alzheimer's disease: attention to butyrylcholinesterase. Curr Med Res Opin 2001;17:159-65.
    • (2001) Curr Med Res Opin , vol.17 , pp. 159-165
    • Greig, N.H.1    Utsuki, T.2    Yu, Q.-S.3
  • 24
    • 0035142278 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease
    • Grutzendler J, Morris JC. Cholinesterase inhibitors for Alzheimer's disease. Drugs 2001;61:41-52.
    • (2001) Drugs , vol.61 , pp. 41-52
    • Grutzendler, J.1    Morris, J.C.2
  • 25
    • 0031458235 scopus 로고    scopus 로고
    • Butyrylcholinesterase in the life cycle of amyloid plaques
    • Guillozet AL, Smiley JF, Mash DC, et al. Butyrylcholinesterase in the life cycle of amyloid plaques. Ann Neurol 1997;42:909-18.
    • (1997) Ann Neurol , vol.42 , pp. 909-918
    • Guillozet, A.L.1    Smiley, J.F.2    Mash, D.C.3
  • 26
    • 0026297796 scopus 로고
    • Cholinesterase-aktivität im menschlichen striatum unter besonderer berücksichtigung der insulae terminales
    • Hartz-Shütt CG, Mai JK. Cholinesterase-aktivität im menschlichen striatum unter besonderer berücksichtigung der insulae terminales. J Hirnforsch 1991;32:317-42.
    • (1991) J Hirnforsch , vol.32 , pp. 317-342
    • Hartz-Shütt, C.G.1    Mai, J.K.2
  • 27
    • 0035012753 scopus 로고    scopus 로고
    • Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease
    • Imbimbo BP. Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease. CNS Drugs 2001;15:375-90.
    • (2001) CNS Drugs , vol.15 , pp. 375-390
    • Imbimbo, B.P.1
  • 28
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease: The Tacrine Study Group
    • Knapp MJ, Knopman DS, Solomon PR, et al. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease: the Tacrine Study Group. JAMA 1994;271:985-91.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3
  • 29
    • 0032931885 scopus 로고    scopus 로고
    • Cholinesterase inhibitors: A therapeutic strategy for Alzheimer disease
    • Krall WJ, Sramek JJ, Cutler NR. Cholinesterase inhibitors: a therapeutic strategy for Alzheimer disease. Ann Pharmacother 1999;33:441-50.
    • (1999) Ann Pharmacother , vol.33 , pp. 441-450
    • Krall, W.J.1    Sramek, J.J.2    Cutler, N.R.3
  • 30
    • 0027973241 scopus 로고
    • Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
    • Mesulam MM, Geula C. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia. Ann Neurol 1994;36:722-7.
    • (1994) Ann Neurol , vol.36 , pp. 722-727
    • Mesulam, M.M.1    Geula, C.2
  • 31
    • 0036183539 scopus 로고    scopus 로고
    • Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain
    • Mesulam M, Guillozet A, Shaw P, et al. Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain. Neurobiol Dis 2002;9:88-93.
    • (2002) Neurobiol Dis , vol.9 , pp. 88-93
    • Mesulam, M.1    Guillozet, A.2    Shaw, P.3
  • 32
    • 0031842293 scopus 로고    scopus 로고
    • Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease
    • Morris JC, Cyrus PA, Orazem J, et al. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease. Neurology 1998;50:1222-30.
    • (1998) Neurology , vol.50 , pp. 1222-1230
    • Morris, J.C.1    Cyrus, P.A.2    Orazem, J.3
  • 33
    • 0029127347 scopus 로고
    • Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020)
    • Nochi S, Asakawa N, Sato T. Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020). Biol Pharm Bull 1995; 18:1145-7.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1145-1147
    • Nochi, S.1    Asakawa, N.2    Sato, T.3
  • 34
    • 0017295228 scopus 로고
    • Some cerebral proteins and enzyme systems in Alzheimer's presenile and senile dementia
    • Op Den Velde W, Stam FC. Some cerebral proteins and enzyme systems in Alzheimer's presenile and senile dementia. J Am Geriatr Soc 1976;24:12-6.
    • (1976) J Am Geriatr Soc , vol.24 , pp. 12-16
    • Op Den Velde, W.1    Stam, F.C.2
  • 35
    • 0018129338 scopus 로고
    • Changes in brain cholinesterases in senile dementia of Alzheimer type
    • Perry EK, Perry RH, Blessed G, et al. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol 1978;4:273-7.
    • (1978) Neuropathol Appl Neurobiol , vol.4 , pp. 273-277
    • Perry, E.K.1    Perry, R.H.2    Blessed, G.3
  • 36
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension
    • The Galantamine USA-1 Study Group
    • Raskind MA, Peskind ER, Wessel T, et al. Galantamine in AD: a 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology 2000;54: 2261-8.
    • (2000) Neurology , vol.54 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3
  • 37
    • 0001517609 scopus 로고    scopus 로고
    • Mechanism of action of cholinesterase inhibitors
    • Giacobini E, ed. London: Martin Dunitz
    • Reiner E, Radic Z. Mechanism of action of cholinesterase inhibitors. In: Giacobini E, ed. Cholinesterases and Cholinesterase Inhibitors. London: Martin Dunitz, 2000:103-19.
    • (2000) Cholinesterases and Cholinesterase Inhibitors , pp. 103-119
    • Reiner, E.1    Radic, Z.2
  • 38
    • 0034771057 scopus 로고    scopus 로고
    • Effects of a flexible galantamine dose in Alzheimer's disease: A randomised, controlled trial
    • Rockwood K, Mintzer J, Truyen L, et al. Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial. J Neurol Neurosurg Psychiatry 2001;71:589-95.
    • (2001) J Neurol Neurosurg Psychiatry , vol.71 , pp. 589-595
    • Rockwood, K.1    Mintzer, J.2    Truyen, L.3
  • 39
    • 0032507788 scopus 로고    scopus 로고
    • Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study
    • Donepezil Study Group
    • Rogers SL, Doody RS, Mohs RC, et al. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Arch Intern Med 1998a;158:1021-31.
    • (1998) Arch Intern Med , vol.158 , pp. 1021-1031
    • Rogers, S.L.1    Doody, R.S.2    Mohs, R.C.3
  • 40
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease: Donepezil Study Group
    • Rogers SL, Farlow MR, Doody RS, et al. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease: Donepezil Study Group. Neurology 1998b;50:136-45.
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3
  • 41
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984;141:1356-64.
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 42
    • 0033528436 scopus 로고    scopus 로고
    • Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial
    • Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. Br Med J 1999;318:633-8.
    • (1999) Br Med J , vol.318 , pp. 633-638
    • Rosler, M.1    Anand, R.2    Cicin-Sain, A.3
  • 43
    • 0030780763 scopus 로고    scopus 로고
    • Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase
    • Saxena A, Redman AM, Jiang X, et al. Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. Biochemistry 1997;36:14642-51.
    • (1997) Biochemistry , vol.36 , pp. 14642-14651
    • Saxena, A.1    Redman, A.M.2    Jiang, X.3
  • 45
    • 0035912825 scopus 로고    scopus 로고
    • Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
    • Shaw KTY, Utsuki T, Rogers J, et al. Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci USA 2001;98:7605-10.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7605-7610
    • Shaw, K.T.Y.1    Utsuki, T.2    Rogers, J.3
  • 47
    • 0033202345 scopus 로고    scopus 로고
    • Rivastigmine: A review
    • Sim A. Rivastigmine: a review. Hosp Med 1999;60:731-5.
    • (1999) Hosp Med , vol.60 , pp. 731-735
    • Sim, A.1
  • 48
    • 0028823072 scopus 로고
    • Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds
    • Sugimoto H, Iimura Y, Yamanishi Y, et al. Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J Med Chem 1995;38:4821-9.
    • (1995) J Med Chem , vol.38 , pp. 4821-4829
    • Sugimoto, H.1    Iimura, Y.2    Yamanishi, Y.3
  • 49
    • 0025778840 scopus 로고
    • Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein
    • Sussman JL, Harel M, Frolow F, et al. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science 1991;253:872-9.
    • (1991) Science , vol.253 , pp. 872-879
    • Sussman, J.L.1    Harel, M.2    Frolow, F.3
  • 50
    • 0032507596 scopus 로고    scopus 로고
    • Tacrine and donepezil attenuate the neurotoxic effect of Aβ(25-35) in rat PC12 cells
    • Svensson AL, Nordberg A. Tacrine and donepezil attenuate the neurotoxic effect of Aβ(25-35) in rat PC12 cells. NeuroReport 1998;9:1519-22.
    • (1998) NeuroReport , vol.9 , pp. 1519-1522
    • Svensson, A.L.1    Nordberg, A.2
  • 51
    • 0034720864 scopus 로고    scopus 로고
    • A 5-month, randomized, placebo-controlled trial of galantamine in AD: The Galantamine USA-10 Study Group
    • Tariot PN, Solomon PR, Morris JC, et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD: the Galantamine USA-10 Study Group. Neurology 2000;54:2269-76.
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1    Solomon, P.R.2    Morris, J.C.3
  • 52
    • 84945058027 scopus 로고
    • Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galantamine, physostigmine and tacrine
    • Thomsen T, Kaden B, Fischer JP, et al. Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galantamine, physostigmine and tacrine. Eur J Clin Chem Clin Biochem 1991;29:487-92.
    • (1991) Eur J Clin Chem Clin Biochem , vol.29 , pp. 487-492
    • Thomsen, T.1    Kaden, B.2    Fischer, J.P.3
  • 54
    • 0019410162 scopus 로고
    • Alzheimer disease: Evidence of selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse PJ, Price DL, Clark AW, et al. Alzheimer disease: evidence of selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981;10:122-6.
    • (1981) Ann Neurol , vol.10 , pp. 122-126
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3
  • 55
    • 0034627263 scopus 로고    scopus 로고
    • Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: Multicentre randomised controlled trial
    • Galantamine International-1 Study Group
    • Wilcock GK, Lilienfeld S, Gaens E. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group. Br Med J 2000;321:1445-9.
    • (2000) Br Med J , vol.321 , pp. 1445-1449
    • Wilcock, G.K.1    Lilienfeld, S.2    Gaens, E.3
  • 56
    • 0027475810 scopus 로고
    • Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease
    • Wright CI, Geula C, Mesulam M-M. Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease. Proc Natl Acad Sci USA 1993;90:683-6.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 683-686
    • Wright, C.I.1    Geula, C.2    Mesulam, M.-M.3


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