High levels of subgenomic HCV plasma RNA in immunosilent infections

Virology

Volumn 365, Issue 2, 2007, Pages 446-456

  Bernardin, Flavien ^a,b   Stramer, Susan L ^c   Rehermann, Barbara ^d   Page Shafer, Kimberly ^e   Cooper, Stewart ^f   Bangsberg, David R ^g   Hahn, Judith ^g   Tobler, Leslie ^a   Busch, Michael ^a,b   Delwart, Eric ^a,b  

^a BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AMERICAN RED CROSS   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^g SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

Defective; HCV; Replicon; Serosilent; Subgenomic

Indexed keywords

GENOMIC RNA; VIRUS RNA;

ARTICLE; BLOOD DONOR; CASE REPORT; HELPER VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; PRIORITY JOURNAL; RNA REPLICATION; SERODIAGNOSIS; T LYMPHOCYTE; VIRUS LOAD; VIRUS MORPHOLOGY; VIRUS PATHOGENESIS; WILD TYPE;

GENOME, VIRAL; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; MOLECULAR SEQUENCE DATA; PLASMA; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; VIRAL STRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 34547670803     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2007.04.003     Document Type: Article

References (73)

1. Aaskov J., Buzacott K., Thu H.M., Lowry K., and Holmes E.C. Long-term transmission of defective RNA viruses in humans and Aedes mosquitoes. Science 311 5758 (2006) 236-238
2. Alberti A., Chemello L., and Benvegnu L. Natural history of hepatitis C. J. Hepatol. 31 Suppl. 1 (1999) 17-24
3. Alter M.J., Kruszon-Moran D., Nainan O.V., McQuillan G.M., Gao F., Moyer L.A., Kaslow R.A., and Margolis H.S. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N. Engl. J. Med. 341 8 (1999) 556-562
4. Appel N., Herian U., and Bartenschlager R. Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A. J. Virol. 79 2 (2005) 896-909
5. Arrojo I.P., Pareja M.O., Orta M.D., Luque F.N., Lamas M.C., Gordo F.S., and Mancha I.V. Detection of a healthy carrier of HCV with no evidence of antibodies for over four years. Transfusion 43 7 (2003) 953-957
6. Barrett A.D., and Dimmock N.J. Defective interfering viruses and infections of animals. Curr. Top. Microbiol. Immunol. 128 (1986) 55-84
7. Bassett S.E., Brasky K.M., and Lanford R.E. Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles. J. Virol. 72 4 (1998) 2589-2599
8. Behrens S.E., Grassmann C.W., Thiel H.J., Meyers G., and Tautz N. Characterization of an autonomous subgenomic pestivirus RNA replicon. J. Virol. 72 3 (1998) 2364-2372
9. Beld M., Penning M., van Putten M., van den Hoek A., Damen M., Klein M.R., and Goudsmit J. Low levels of hepatitis C virus RNA in serum, plasma, and peripheral blood mononuclear cells of injecting drug users during long antibody-undetectable periods before seroconversion. Blood 94 4 (1999) 1183-1191
10. Bernardin F., Herring B., Page-Shafer K., Kuiken C., and Delwart E. Absence of HCV viral recombination following superinfection. J. Viral Hepatitis 13 8 (2006) 532-537
11. Booth J.C., Kumar U., Webster D., Monjardino J., and Thomas H.C. Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients. Hepatology 27 1 (1998) 223-227
12. + T cell immunity: HCV evolution, from chimpanzees to man. J. Exp. Med. 201 11 (2005) 1709-1714
13. Bowen D.G., and Walker C.M. The origin of quasispecies: cause or consequence of chronic hepatitis C viral infection?. J. Hepatol. 42 3 (2005) 408-417
14. Brinton M.A. Analysis of extracellular West Nile virus particles produced by cell cultures from genetically resistant and susceptible mice indicates enhanced amplification of defective interfering particles by resistant cultures. J. Virol. 46 3 (1983) 860-870
15. Busch M.P. Insights into the epidemiology, natural history and pathogenesis of hepatitis C virus infection from studies of infected donors and blood product recipients. Transfus. Clin. Biol. 8 3 (2001) 200-206
16. Busch M.P., and Shafer K.A. Acute-phase hepatitis C virus infection: implications for research, diagnosis, and treatment. Clin. Infect. Dis. 40 7 (2005) 959-961
17. Busch M.P., Korelitz J.J., Kleinman S.H., Lee S.R., AuBuchon J.P., and Schreiber G.B. Declining value of alanine aminotransferase in screening of blood donors to prevent posttransfusion hepatitis B and C virus infection. The Retrovirus Epidemiology Donor Study. Transfusion 35 11 (1995) 903-910
18. Castillo I., Pardo M., Bartolome J., Ortiz-Movilla N., Rodriguez-Inigo E., de Lucas S., Salas C., Jimenez-Heffernan J.A., Perez-Mota A., Graus J., Lopez-Alcorocho J.M., and Carreno V. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J. Infect. Dis. 189 1 (2004) 7-14
19. Charleston B., Fray M.D., Baigent S., Carr B.V., and Morrison W.I. Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with a failure to induce type I interferon. J. Gen. Virol. 82 Pt. 8 (2001) 1893-1897
20. Chien D.Y., Arcangel P., Medina-Selby A., Coit D., Baumeister M., Nguyen S., George-Nascimento C., Gyenes A., Kuo G., and Valenzuela P. Use of a novel hepatitis C virus (HCV) major-epitope chimeric polypeptide for diagnosis of HCV infection. J. Clin. Microbiol. 37 5 (1999) 1393-1397
21. Debnath N.C., Tiernery R., Sil B.K., Wills M.R., and Barrett A.D. In vitro homotypic and heterotypic interference by defective interfering particles of West Nile virus. J. Gen. Virol. 72 Pt. 11 (1991) 2705-2711
22. Durand F., Beauplet A., and Marcellin P. Evidence of hepatitis C virus viremia without detectable antibody to hepatitis C virus in a blood donor. Ann. Intern. Med. 133 1 (2000) 74-75
23. Durand F., Danic B., Tardivel R., Semana G., Gouezec H., Martinot M., Marcellin P., and Beauplet A. Discovery of a chronic HVC infection without seroconversion in a blood donor in France during 28 months. Transfus. Clin. Biol. 7 3 (2000) 242-250
24. Durand F., Danic B., Tardivel R., Semana G., Gouezec H., Martinot M., Marcellin P., and Beauplet A. Discovery of a chronic HVC infection without seroconversion in a blood donor in France during 28 months. Transfus. Clin. Biol. 7 3 (2000) 242-250
25. Evans M.J., Rice C.M., and Goff S.P. Genetic interactions between hepatitis C virus replicons. J. Virol. 78 21 (2004) 12085-12089
26. Grakoui A., Shoukry N.H., Woollard D.J., Han J.H., Hanson H.L., Ghrayeb J., Murthy K.K., Rice C.M., and Walker C.M. HCV persistence and immune evasion in the absence of memory T cell help. Science 302 5645 (2003) 659-662
27. Grassmann C.W., Isken O., Tautz N., and Behrens S.E. Genetic analysis of the pestivirus nonstructural coding region: defects in the NS5A unit can be complemented in trans. J. Virol. 75 17 (2001) 7791-7802
28. Hahn J.A., Page-Shafer K., Lum P.J., Bourgois P., Stein E., Evans J.L., Busch M.P., Tobler L.H., Phelps B., and Moss A.R. Hepatitis C virus seroconversion among young injection drug users: relationships and risks. J. Infect. Dis. 186 11 (2002) 1558-1564
29. Hall C.S., Charlebois E.D., Hahn J.A., Moss A.R., and Bangsberg D.R. Hepatitis C virus infection in San Francisco's HIV-infected urban poor. J. Gen. Intern. Med. 19 4 (2004) 357-365
30. Herring B.L., Page-Shafer K., Tobler L.H., and Delwart E.L. Frequent hepatitis C virus superinfection in injection drug users. J. Infect. Dis. 190 8 (2004) 1396-1403
31. Huang A.S., and Baltimore D. Defective viral particles and viral disease processes. Nature 226 5243 (1970) 325-327
32. Iwai A., Marusawa H., Takada Y., Egawa H., Ikeda K., Nabeshima M., Uemoto S., and Chiba T. Identification of novel defective HCV clones in liver transplant recipients with recurrent HCV infection. J. Viral Hepatitis 13 8 (2006) 523-531
33. Kageyama S., Agdamag D.M., Alesna E.T., Leano P.S., Heredia A.M., Abellanosa-Tac-An I.P., Jereza L.D., Tanimoto T., Yamamura J., and Ichimura H. A natural inter-genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines. J. Med. Virol. 78 11 (2006) 1423-1428
34. Kalinina O., Norder H., Mukomolov S., and Magnius L.O. A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg. J. Virol. 76 8 (2002) 4034-4043
35. Khromykh A.A., and Westaway E.G. Subgenomic replicons of the flavivirus Kunjin: construction and applications. J. Virol. 71 2 (1997) 1497-1505
36. Khromykh A.A., Sedlak P.L., and Westaway E.G. cis- and trans-acting elements in flavivirus RNA replication. J. Virol. 74 7 (2000) 3253-3263
37. Kupfermann H., Thiel H.J., Dubovi E.J., and Meyers G. Bovine viral diarrhea virus: characterization of a cytopathogenic defective interfering particle with two internal deletions. J. Virol. 70 11 (1996) 8175-8181
38. Lancaster M.U., Hodgetts S.I., Mackenzie J.S., and Urosevic N. Characterization of defective viral RNA produced during persistent infection of Vero cells with Murray Valley encephalitis virus. J. Virol. 72 3 (1998) 2474-2482
39. Legrand-Abravanel F., Claudinon J., Nicot F., Dubois M., Chapuy-Regaud S., Sandres-Saune K., Pasquier C., and Izopet J. A new natural intergenotypic (2/5) recombinant of Hepatitis C virus. J. Virol. 81 8 (2007) 4357-4362
40. Lin S., Arcangel P., Medina-Selby A., Coit D., Ng P., Nguyen S., McCoin C., Gyenes A., Hu C., Tandeske L., Phelps B., and Chien D. Design of novel conformational and genotype-specific antigens for improving sensitivity of immunoassays for hepatitis C virus-specific antibodies. J. Clin. Microbiol. 43 8 (2005) 3917-3924
41. Liu W.J., Sedlak P.L., Kondratieva N., and Khromykh A.A. Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assembly. J. Virol. 76 21 (2002) 10766-10775
42. Lohmann V., Korner F., Koch J., Herian U., Theilmann L., and Bartenschlager R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285 5424 (1999) 110-113
43. Maple P.A., McKee T., Desselberger U., and Wreghitt T.G. Hepatitis C virus infections in transplant patients: serological and virological investigations. J. Med. Virol. 44 1 (1994) 43-48
44. Meyers G., and Thiel H.J. Cytopathogenicity of classical swine fever virus caused by defective interfering particles. J. Virol. 69 6 (1995) 3683-3689
45. Morand P., Dutertre N., Minazzi H., Burnichon J., Pernollet M., Baud M., Zarski J.P., and Seigneurin J.M. Lack of seroconversion in a health care worker after polymerase chain reaction-documented acute hepatitis C resulting from a needlestick injury. Clin. Infect. Dis. 33 5 (2001) 727-729
46. Moreau I., Hegarty S., Levis J., Sheehy P., Crosbie O., Kenny-Walsh E., and Fanning L.J. Serendipitous identification of natural intergenotypic recombinants of hepatitis C in Ireland. Virol. J. 3 (2006) 95
47. Nagayama K., Kurosaki M., Enomoto N., Maekawa S.Y., Miyasaka Y., Tazawa J., Izumi N., Marumo F., and Sato C. Time-related changes in full-length hepatitis C virus sequences and hepatitis activity. Virology 263 1 (1999) 244-253
48. Nei M., and Gojobori T. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol. Biol. Evol. 3 5 (1986) 418-426
49. Neumann A.U., Lam N.P., Dahari H., Gretch D.R., Wiley T.E., Layden T.J., and Perelson A.S. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 282 5386 (1998) 103-107
50. Noppornpanth S., Lien T.X., Poovorawan Y., Smits S.L., Osterhaus A.D., and Haagmans B.L. Identification of a naturally occurring recombinant genotype 2/6 hepatitis C virus. J. Virol. 80 15 (2006) 7569-7577
51. Ota T., and Nei M. Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site. Mol. Biol. Evol. 11 4 (1994) 613-619
52. Paterson D.L., Gayowski T., Wannstedt C.F., Wagener M.M., Marino I.R., Vargas H., Laskus T., Rakela J., and Singh N. Quality of life in long-term survivors after liver transplantation: impact of recurrent viral hepatitis C virus hepatitis. Clin. Transplant. 14 1 (2000) 48-54
53. Peoples B.G., Preston S.B., Tzeng J.L., Stramer S.L., Gifford L., and Wissel M.E. Prolonged antibody-negative HCV viremia in a US blood donor with apparent HCV transmission to a recipient. Transfusion 40 10 (2000) 1280-1281
54. Peterhans E., Jungi T.W., and Schweizer M. BVDV and innate immunity. Biologicals 31 2 (2003) 107-112
55. Pijlman G.P., Kondratieva N., and Khromykh A.A. Translation of the Flavivirus Kunjin NS3 gene in cis but not its RNA sequence or secondary structure is essential for efficient RNA packaging. J. Virol. 80 22 (2006) 11255-11264
56. Prince A.M., Pawlotsky J.M., Soulier A., Tobler L., Brotman B., Pfahler W., Lee D.H., Li L., and Shata M.T. Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infections. J. Viral Hepatitis 11 3 (2004) 236-242
57. Rahman F., Heller T., Sobao Y., Mizukoshi E., Nascimbeni M., Alter H., Herrine S., Hoofnagle J., Liang T.J., and Rehermann B. Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology 40 1 (2004) 87-97
58. Rehermann B. Interaction between the hepatitis C virus and the immune system. Semin. Liver Dis. 20 2 (2000) 127-141
59. Rehermann B., and Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev., Immunol. 5 3 (2005) 215-229
60. Roux L., Simon A.E., and Holland J.J. Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo. Adv. Virus Res. 40 (1991) 181-211
61. Schmidt W.N., Wu P., Cederna J., Mitros F.A., LaBrecque D.R., and Stapleton J.T. Surreptitious hepatitis C virus (HCV) infection detected in the majority of patients with cryptogenic chronic hepatitis and negative HCV antibody tests. J. Infect. Dis. 176 1 (1997) 27-33
62. Seeff L.B. Natural history of chronic hepatitis C. Hepatology 36 5 Suppl. 1 (2002) S35-S46
63. Shimizu Y.K., Hijikata M., Iwamoto A., Alter H.J., Purcell R.H., and Yoshikura H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J. Virol. 68 3 (1994) 1494-1500
64. Stramer S.L., Glynn S.A., Kleinman S.H., Strong D.M., Caglioti S., Wright D.J., Dodd R.Y., and Busch M.P. Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing. N. Engl. J. Med. 351 8 (2004) 760-768
65. Takaki A., Wiese M., Maertens G., Depla E., Seifert U., Liebetrau A., Miller J.L., Manns M.P., and Rehermann B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat. Med. 6 5 (2000) 578-582
66. Tautz N., Thiel H.J., Dubovi E.J., and Meyers G. Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion. J. Virol. 68 5 (1994) 3289-3297
67. Timm J., Lauer G.M., Kavanagh D.G., Sheridan I., Kim A.Y., Lucas M., Pillay T., Ouchi K., Reyor L.L., Zur Wiesch J.S., Gandhi R.T., Chung R.T., Bhardwaj N., Klenerman P., Walker B.D., and Allen T.M. CD8 epitope escape and reversion in acute HCV infection. J. Exp. Med. 200 12 (2004) 1593-1604
68. Tobler L.H., Stramer S.L., Chien D.Y., Lin S., Arcangel P., Phelps B.H., Cooper S.L., and Busch M.P. Antibodies to a novel antigen in acute hepatitis C virus infections. Vox Sang. 92 1 (2007) 1-7
69. Wang W.K., Sung T.L., Lee C.N., Lin T.Y., and King C.C. Sequence diversity of the capsid gene and the nonstructural gene NS2B of dengue-3 virus in vivo. Virology 303 1 (2002) 181-191
70. Wasley A., and Alter M.J. Epidemiology of hepatitis C: geographic differences and temporal trends. Semin. Liver Dis. 20 1 (2000) 1-16
71. Yagi S., Mori K., Tanaka E., Matsumoto A., Sunaga F., Kiyosawa K., and Yamaguchi K. Identification of novel HCV subgenome replicating persistently in chronic active hepatitis C patients. J. Med. Virol. 77 3 (2005) 399-413
72. Yuen M.F., and Lai C.L. Natural history of chronic hepatitis B virus infection. J. Gastroenterol. Hepatol. 15 (2000) E20-E24 Suppl
73. Zoulim F., Chevallier M., Maynard M., and Trepo C. Clinical consequences of hepatitis C virus infection. Rev. Med. Virol. 13 1 (2003) 57-68