Detection of a healthy carrier of HCV with no evidence of antibodies for over four years

Transfusion

Volumn 43, Issue 7, 2003, Pages 953-957

  Prat Arrojo, Isidro ^b   Ortiz Pareja, Macarena ^a   Retamero Orta, Maria Dolores ^b   Navajas Luque, Federico ^b   Hernandez Lamas, Maria Carmen ^b   Sanchez Gordo, Francisco ^b   Vidales Mancha, Isabel ^b  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

RNA; VIRUS ANTIGEN;

ADULT; ANTIBODY DETECTION; ANTIBODY SCREENING; ARTICLE; BLOOD BANK; BLOOD TRANSFUSION; CASE REPORT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOASSAY; POLYMERASE CHAIN REACTION; POSTTRANSFUSION HEPATITIS; VIRUS CARRIER; VIRUS CORE;

BIOPSY; BLOOD COMPONENT TRANSFUSION; BLOOD DONORS; ERYTHROCYTE TRANSFUSION; FALSE NEGATIVE REACTIONS; FEMALE; HEPACIVIRUS; HEPATITIS C ANTIBODIES; HEPATITIS C, CHRONIC; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIVER; LYMPHOCYTE SUBSETS; PLASMA; PLATELET TRANSFUSION; POLYMERASE CHAIN REACTION; PREGNANCY; RNA, VIRAL; SPAIN;

EID: 0037969919     PISSN: 00411132     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1537-2995.2003.00445.x     Document Type: Article

References (22)

1. Kleinman S, Busch MP, Korelitz JJ, Schreiber GB. The incidence/window period model and its use to assess the risk of transfusion-transmitted human immunodeficiency virus and hepatitis C virus infection. Transfus Med Rev 1997;11:155-72.
2. Humpe A, Legler TJ, Nübling CM, et al. Hepatitis C virus transmission through quarantine fresh-frozen plasma. Thromb Haemost 2000;84:784-8.
3. Vrielink H, van der Poel CL, Reesink HW, et al. Transmission of hepatitis C virus by anti-HCV-negative blood transfusion. Case report. Vox Sang 1995;68:55-6.
4. Peterson J, Green G, Iida K, et al. Detection of hepatitis C core antigen in the antibody negative "window" phase of hepatitis C infection. Vox Sang 2000;78:80-5.
5. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001;345:41-52.
6. Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ. The risk of transfusion-transmitted viral infections. N Engl J Med 1996;334:1685-90.
7. Busch MP, Korelitz JJ, Kleinman SH, et al. Declining value of alanine aminotransferase in screening of blood donors to prevent posttransfusion hepatitis B and C virus infection. The Retrovirus Epidemiology Donor Study. Transfusion 1995;35:903-10.
8. Durand F, Danic B, Tardivel R, et al. Detection of an HCV chronic carrier state without anti-HCV antibody in a blood donor during 28 months. Transfus Clin Biol 2000;7:242-50.
9. Beld M, Penning M, van Putten M, et al. Low levels of hepatitis C virus RNA in serum, plasma, and peripheral blood mononuclear cells of injecting drug users during long antibody-undetectable periods before seroconversion. Blood 1999;94:1183-91.
10. Takaki A, Wiese M, Maertens G, et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000;6:578-82.
11. Maple PA, McKee T, Desselberger U, Wreghitt TG. Hepatitis C virus infection in transplant patients: serological and virological investigations. J Med Virol 1994;44:43-8.
12. Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992;327:1490-5.
13. Alter MJ, Margolis HS, Krawczynski K, et al. The natural history of community-acquired hepatitis C in the United States. N Engl J Med 1992;327:1899-905.
14. Schmidt WN, Wu P, Cederna JM, et al. Surreptitious hepatitis C virus (HCV) infection detected in the majority of patients with cryptogenic chronic hepatitis and negative HCV antibody tests. J Infect Dis 1997;176:27-33.
15. Stapleton JT, Klinzman D, Schmidt WN, et al. Prospective comparison of whole-blood-and plasma-based hepatitis C virus RNA detection systems: improved detection using whole blood as the source of viral RNA. J Clin Microbiol 1999;37:484-9.
16. Vrielink H, Reesink HW, van den Burg PJ, et al. Performance of three three generations of anti-hepatitis C virus enzyme-linked immunosorbent assays in donors and patients. Transfusion 1997;37:845-9.
17. Kao JH, Lai MY, Hwang YT, et al. Chronic hepatitis C without anti-hepatitis C antibodies by second-generation assay. A clinicopathologic study and demonstration of the usefulness of a third-generation assay. Dig Dis Sci 1996;41:161-5.
18. Roth WK, Weber M, Seifried E. Feasibility and efficacy of routine PCR screening of blood donations for hepatitis C virus, hepatitis B virus, and HIV-1 in a blood-bank setting. Lancet 1999;353:359-63.
19. Koerner K, Cardoso M, Dengler T, et al. Estimated risk of transmission of hepatitis C virus by blood transfusion. Vox Sang 1998;74:213-6.
20. Cardoso MS, Koerner K, Kubanek B. Mini-pool screening by nucleic acid testing for hepatitis B virus, hepatitis C virus, and HIV: preliminary results. Transfusion 1998;38:905-7.
21. Legler TJ, Riggert J, Simson G, et al. Testing of individual blood donations for HCV RNA reduces the residual risk of transfusion-transmitted HCV infection. Transfusion 2000;40:1192-7.
22. Loubiere S, Rotily M, Durand-Zaleski I, Costagliola D. Including polymerase chain reaction in screening for hepatitis C virus RNA in blood donations is not cost-effective. Vox Sang 2001;80:199-204.