Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation

JARO - Journal of the Association for Research in Otolaryngology

Volumn 4, Issue 2, 2003, Pages 139-147

  Satoh, Hitoshi ^a,c   Firestein, Gary S ^b   Billings, Peter B ^a   Harris, Jeffrey P ^a,c   Keithley, Elizabeth M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Innate immunity; Inner ear immunity cochlear inflammation

Indexed keywords

CYTOKINE; ETANERCEPT; INTERLEUKIN 1BETA; INTERLEUKIN 6; KEYHOLE LIMPET HEMOCYANIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCHLEA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOLYMPHATIC SAC; FEMALE; HEARING LOSS; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; INNER EAR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ENDOLYMPHATIC SAC; FEMALE; HEMOCYANIN; IMMUNOGLOBULIN G; INFLAMMATION MEDIATORS; INJECTIONS; INTERLEUKIN-1; INTERLEUKIN-6; LABYRINTHITIS; MICE; RECEPTORS, TUMOR NECROSIS FACTOR; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037634008     PISSN: 15253961     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10162-002-3025-7     Document Type: Article

References (23)

1. ADAMS JC. Clinical implications of inflammatory cytokines in the cochlea. Otol. Neurotol. 23:316-322, 2002.
2. CHEN M-C, HARRIS JP, KEITHLEY EM. Immunohistochemical analysis of proliferating cells in a sterile labyrinthitis animal model. Laryngoscope 108:651-656, 1998.
3. HARRIS JP. Immunology of the inner ear: Evidence of local antigen production. Ann. Otol. Rhinol. Laryngol. 93:158-162, 1984.
4. IWAI H, TOMODA K, SUGIURA K, INABA M, IKEHARA S, YAMASHITA T. T cells infiltrating from the systemic circulation proliferate in the endolymphatic sac. Ann. Otol. Rhinol. Laryngol. 108:1146-1150, 1999.
5. JUHN SK. The nature of blood labyrinth barrier in experimental conditions. Ann. Otol. Rhinol. Laryngol. 90:135-141, 1981.
6. KANZAKI J, OUCHI T. Steroid-responsive bilateral sensorineural hearing loss and immune complexes. Arch. Otolaryngol. 230:59, 1981.
7. KAWAUCHI H, ICHIMIYA I, KANEDA N, MOGI G. Distribution of immunocompetent cells in the endolymphatic sac. Ann. Otol. Rhinol. Laryngol. 101:39-47, 1992.
8. MA C-L, BILLINGS PB, HARRIS JP, KEITHLEY EM. Characterization of an experimentally induced inner ear immune response: Laryngoscope 110:451-456, 2000.
9. McCABE BF. Autoimmune sensorineural hearing loss. Ann. Otol. Rhinol. Laryngol. 88:585-589, 1992.
10. RASK-ANDERSEN H, STAHLE J. Lymphocyte-macrophage activity in the endolymphatic sac. An ultrastructural study of the rugose endolymphatic sac in the guinea pig. ORL J. Otorhinolaryngol. Relat. Spec. 41:177-192, 1979.
11. RASK-ANDERSEN, H, STAHLE J. Immunodefence of the inner ear? Lymphocyte-macrophage interaction in the endolymphatic sac. Acta Otolaryngol. Stockh. 89:283-294, 1980.
12. RASK-ANDERSEN H, BAGGER-SJOBACK D, LUNDQUIST PG. The fenestrated blood vessels of the endolymphatic sac. A freeze-fracture and transmission electron microscopic study. Am. J. Otol. 4:214-221, 1983.
13. SATOH H. Anti-glomerular basement membrane antibody-induced inflammation in rat cochlear plexus. Acta Otolaryngol. (Stockh.) 117:80-86, 1997.
14. SATOH H, FIRESTEIN GS, BILLINGS PB, HARRIS JP, KEITHLEY EM. TNFα as an initiator and etanercept as a potential therapeutic inhibitor of inner ear inflammation. Laryngoscope 112:1627-1634, 2002.
15. TAKAHASHI M, HARRIS JP. Anatomic distribution and localization of immunocompetent cells in normal mouse endolymphatic sac. Acta Otolaryngol. (Stockh.) 106:409-416, 1988a.
16. TAKAHASHI M, HARRIS JP. Analysis of immunocompetent cells following inner ear immunostimulation. Laryngoscope 98:1133-1138, 1988b.
17. TAKAKASHI M, TIMIYAMA S. Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation. Acta Otolaryngol. (Stockh.) 115:396-399, 1995.
18. TOMIYAMA S, HARRIS JP. The endolymphatic sac: its importance in inner ear immune responses. Laryngoscope 96:685-691, 1986.
19. TOMIYAMA S, HARRIS JP. The role of the endolymphatic sac in inner ear immunity. Acta Otolaryngol. (Stockh.) 103:182-188, 1987.
20. TOMIYAMA S, HARRIS JP. Elevation of inner ear antibody levels following direct antigen challenge of the endolymphatic sac. Acta Otolaryngol. (Stockh.) 107:202-209, 1989.
21. WANG X, BILLINGS PB, FIRESTEIN GS, HARRIS JP, KEITHLEY EM. Application of Enbrel in experimental immune-mediated sensorineural hearing loss. Assoc. Res. Otolaryngol. Abstr. 25:92, 2002.
22. YEO SW, GOTTESCHLICH S, HARRIS JP, KEITHLEY EM. Antigen diffusion from the perilymphatic space of the cochlea. Laryngoscope 105:623-628, 1995.
23. YIMTAE K, SONG H, BILLINGS P, HARRIS JP, KEITHLEY EM. Connection between the inner ear and the lymphatic system. Laryngoscope 111:1631-1635, 2001.