-
1
-
-
0028069130
-
Identity-by-descent and association mapping of a recessive gene for Hirschspring disease on human chromosome 13q22
-
Puffenberger, E. G. et al. Identity-by-descent and association mapping of a recessive gene for Hirschspring disease on human chromosome 13q22. Hum. Mol. Genet. 3, 1217-1225 (1994).
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 1217-1225
-
-
Puffenberger, E.G.1
-
2
-
-
0028618372
-
A missense mutation of the Endothelin-B receptor gene in multigenic Hirschsprung's disease
-
Puffenberger, E. G. et al. A missense mutation of the Endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 79, 1257-1266 (1994). References 1 and 2 provide an early, beautiful example of how a complex disease can become a simple disease and how a population isolate can be used to dissect a phenotype.
-
(1994)
Cell
, vol.79
, pp. 1257-1266
-
-
Puffenberger, E.G.1
-
3
-
-
0029162902
-
Nonsyndromic autosomal recessive deafness is linked to the DFNBI locus in a large inbred Bedouin family from Israel
-
Scott D. A. et al. Nonsyndromic autosomal recessive deafness is linked to the DFNBI locus in a large inbred Bedouin family from Israel. Am. J. Hum. Genet. 57, 965-968 (1995).
-
(1995)
Am. J. Hum. Genet.
, vol.57
, pp. 965-968
-
-
Scott, D.A.1
-
5
-
-
0032005372
-
The DNA revolution in population genetics
-
Cavalli-Sforza, L The DNA revolution in population genetics. Trends Genet. 14, 60-65 (1998).
-
(1998)
Trends Genet.
, vol.14
, pp. 60-65
-
-
Cavalli-Sforza, L.1
-
6
-
-
0033941841
-
Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global, MH representation of populations
-
Kidd, J. R. et al. Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global, MH representation of populations. Am. J. Hum. Genet. 66, 1882-1899 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 1882-1899
-
-
Kidd, J.R.1
-
7
-
-
0029859306
-
Paternal and maternal linkages reveal a bottleneck in the founding of the Finnish population
-
Sajantila, A. et al. Paternal and maternal linkages reveal a bottleneck in the founding of the Finnish population. Proc. Natl Acad. Sci. USA 93, 12035-12039 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 12035-12039
-
-
Sajantila, A.1
-
8
-
-
0031971898
-
Dual origins of Finns revealed by Y chromosome haplotype variation
-
Kittles, R. A. et al. Dual origins of Finns revealed by Y chromosome haplotype variation. Am. J. Hum. Genet. 62, 1171-1179 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 1171-1179
-
-
Kittles, R.A.1
-
9
-
-
0032514681
-
Linkage disequilibrium mapping in isolate populations: The example of Finland revisited
-
de la Chapelle, A & Wright F. A. Linkage disequilibrium mapping in isolate populations: The example of Finland revisited. Proc. Natl Acad. Sci. USA 95, 12416-12423 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 12416-12423
-
-
De La Chapelle, A.1
Wright, F.A.2
-
10
-
-
0033992637
-
Gene mapping in isolated populations: New roles for old friends?
-
Jorde, L. B. et al. Gene mapping in isolated populations: New roles for old friends? Hum. Hered. 50, 57-65 (2000).
-
(2000)
Hum. Hered.
, vol.50
, pp. 57-65
-
-
Jorde, L.B.1
-
11
-
-
0033869708
-
Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo
-
in the press
-
Varilo, T. et al. Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo. Eur. J. Hum. Genet. (in the press).
-
Eur. J. Hum. Genet.
-
-
Varilo, T.1
-
12
-
-
0031946381
-
Mapping in small populations with no demographic expansion
-
Terwilliger, J. D., Zöllner, S., Laan, M. & Pääbo, S. Mapping in small populations with no demographic expansion. Hum. Hered. 48, 138-154 (1998).
-
(1998)
Hum. Hered.
, vol.48
, pp. 138-154
-
-
Terwilliger, J.D.1
Zöllner, S.2
Laan, M.3
Pääbo, S.4
-
13
-
-
0033992497
-
Positional cloning of disease genes: Advantages of genetic isolates
-
Peltonen, L. Positional cloning of disease genes: Advantages of genetic isolates. Hum. Hered. 50, 66-75 (2000).
-
(2000)
Hum. Hered.
, vol.50
, pp. 66-75
-
-
Peltonen, L.1
-
14
-
-
0032869123
-
Molecular genetics of the Finnish disease heritage
-
Peltonen, L., Jalanko, A. & Varilo, T. Molecular genetics of the Finnish disease heritage. Hum. Mol. Genet. 8, 1913-1923 (1999).
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1913-1923
-
-
Peltonen, L.1
Jalanko, A.2
Varilo, T.3
-
15
-
-
0032707163
-
Population choice in mapping genes for complex diseases
-
Wright, A. F., Carothers, A. D. & Pirastu, M. Population choice in mapping genes for complex diseases. Nature Genet. 23, 397-404 (1999). Considers in some detail the advantages and disadvantages of various populations in mapping common disease genes.
-
(1999)
Nature Genet.
, vol.23
, pp. 397-404
-
-
Wright, A.F.1
Carothers, A.D.2
Pirastu, M.3
-
16
-
-
0027942323
-
Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis
-
Houwen, R. H. et al. Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis. Nature Genet. 8, 380-386 (1994). Shows the power of the founder effect and population isolation in the search for a disease gene. Scanning for a haplotype signature in affected individuals can be used to localize the gene.
-
(1994)
Nature Genet.
, vol.8
, pp. 380-386
-
-
Houwen, R.H.1
-
17
-
-
0242581229
-
Random search for shared chromosomal regions: The assignment of a new hereditary ataxia locus
-
Nikali, K. et al. Random search for shared chromosomal regions: the assignment of a new hereditary ataxia locus. Am. J. Hum. Genet. 56, 1083-1095 (1995).
-
(1995)
Am. J. Hum. Genet.
, vol.56
, pp. 1083-1095
-
-
Nikali, K.1
-
18
-
-
0027263363
-
Genetic mapping of a locus predisposing to human colorectal cancer
-
Peltomaki, P. et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science 260, 810-812 (1993).
-
(1993)
Science
, vol.260
, pp. 810-812
-
-
Peltomaki, P.1
-
19
-
-
0031918837
-
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
-
Pajukanta, P. et al. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nature Genet. 18, 369-373 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 369-373
-
-
Pajukanta, P.1
-
20
-
-
0032231322
-
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
-
Hanson, R. L. et al. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am. J. Hum. Genet. 63, 1130-1138 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 1130-1138
-
-
Hanson, R.L.1
-
21
-
-
0030688004
-
Variations on a theme: Cataloguing human DNA sequence variation
-
Collins, F. S., Guyer, M. S. & Charkravarti, A. Variations on a theme: cataloguing human DNA sequence variation. Science 278, 1580-1581 (1997). Lays out the rationale for the discovery and application of single nucleotide polymorphisms.
-
(1997)
Science
, vol.278
, pp. 1580-1581
-
-
Collins, F.S.1
Guyer, M.S.2
Charkravarti, A.3
-
22
-
-
0033039497
-
Prospect for whole-genome linkage disequilibrium mapping of common disease genes
-
Kruglyak, L. Prospect for whole-genome linkage disequilibrium mapping of common disease genes. Nature Genet. 22, 139-144 (1999).
-
(1999)
Nature Genet.
, vol.22
, pp. 139-144
-
-
Kruglyak, L.1
-
23
-
-
24844432526
-
Characterizing human genomic variation and linkage disequililibrium in multiple 100kb genomic segments using large-scale, microarray-based SNP detection
-
Zwick, M. E. et al. Characterizing human genomic variation and linkage disequililibrium in multiple 100kb genomic segments using large-scale, microarray-based SNP detection. Am. J. Hum. Genet. 67, S22 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.67
-
-
Zwick, M.E.1
-
24
-
-
17344364213
-
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
-
Nickerson, D. A. et al. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nature Genet. 19, 233-240 (1998). Explores one human gene intensely for polymorphisms and linkage disequilibrium. This type of study is a forerunner of what will be done on a genome-wide basis.
-
(1998)
Nature Genet.
, vol.19
, pp. 233-240
-
-
Nickerson, D.A.1
-
25
-
-
0033918564
-
The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes
-
Eaves, I. A. et al. The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nature Genet. 25, 320-323 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 320-323
-
-
Eaves, I.A.1
-
26
-
-
0033930144
-
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28
-
Taillon-Miller, P. et al. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nature Genet. 25, 324-328 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 324-328
-
-
Taillon-Miller, P.1
-
27
-
-
24844477220
-
Marker-marker linkage disequilibrium extends beyond 1 cM on chromosome 20 in Finns
-
Moehlke, K. L. et al. Marker-marker linkage disequilibrium extends beyond 1 cM on chromosome 20 in Finns. Am. J. Human Genet. 67, S25 (2000).
-
(2000)
Am. J. Human Genet.
, vol.67
-
-
Moehlke, K.L.1
-
28
-
-
0032231937
-
The power to detect linkage in complex disease by means of simple LOD-score analyses
-
Greenberg, D. A., Abreu, P. & Hodge, S. E. The power to detect linkage in complex disease by means of simple LOD-score analyses. Am. J. Hum. Genet. 63, 870-879 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 870-879
-
-
Greenberg, D.A.1
Abreu, P.2
Hodge, S.E.3
-
29
-
-
0022728801
-
Effects of misspecifying genetic parameters in led score analysis
-
Clerget-Darpoux, F., Bonaiti-Pellie, C. & Hochez, J. Effects of misspecifying genetic parameters in led score analysis. Biometrics 42, 393-399 (1986).
-
(1986)
Biometrics
, vol.42
, pp. 393-399
-
-
Clerget-Darpoux, F.1
Bonaiti-Pellie, C.2
Hochez, J.3
-
30
-
-
0029886532
-
Parametric and nonparametric linkage analysis: A unified multipoint approach
-
Kruglyak, L., Daly, M. J., Reeve-Daly, M. P. & Lander, E. S. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am. J. Hum. Genet. 58, 1347-1363 (1996).
-
(1996)
Am. J. Hum. Genet.
, vol.58
, pp. 1347-1363
-
-
Kruglyak, L.1
Daly, M.J.2
Reeve-Daly, M.P.3
Lander, E.S.4
-
31
-
-
0029945706
-
Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker sharing statistics
-
Sobel, E. & Lange, K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker sharing statistics. Am. J. Hum. Genet. 58, 1323-1337 (1996).
-
(1996)
Am. J. Hum. Genet.
, vol.58
, pp. 1323-1337
-
-
Sobel, E.1
Lange, K.2
-
32
-
-
0033362231
-
Direct power comparisons between simple lod scores and NPL scores for linkage analysis in complex diseases
-
Abreu, P. C., Greenberg, D. A. & Hodge, S. E. Direct power comparisons between simple lod scores and NPL scores for linkage analysis in complex diseases. Am. J. Hum. Genet. 65, 847-857 (1999).
-
(1999)
Am. J. Hum. Genet.
, vol.65
, pp. 847-857
-
-
Abreu, P.C.1
Greenberg, D.A.2
Hodge, S.E.3
-
33
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996). Argues the case for association studies over linkage studies.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
34
-
-
0026494911
-
A haplotype-based 'haplotype relative risk' approach to detecting allelic associations
-
Terwilliger, J. D. & Ott, J. A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum. Hered. 42, 337-346 (1992).
-
(1992)
Hum. Hered.
, vol.42
, pp. 337-346
-
-
Terwilliger, J.D.1
Ott, J.2
-
35
-
-
0027377799
-
Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
-
Spielman, R. S., McGinnis, R. E. & Ewens, W. J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-516 (1993).
-
(1993)
Am. J. Hum. Genet.
, vol.52
, pp. 506-516
-
-
Spielman, R.S.1
McGinnis, R.E.2
Ewens, W.J.3
-
36
-
-
0033358532
-
Sibling-based tests of linkage and association for quantitative traits
-
Allison, D. B., Heo, M., Kaplan, N. & Martin, E. R. Sibling-based tests of linkage and association for quantitative traits. Am. J. Hum. Genet. 64, 1754-1763 (1999).
-
(1999)
Am. J. Hum. Genet.
, vol.64
, pp. 1754-1763
-
-
Allison, D.B.1
Heo, M.2
Kaplan, N.3
Martin, E.R.4
-
37
-
-
0031949273
-
Genetic association mapping based on discordant sib pairs: The discordant-alleles test
-
Boehnke, M. & Langefeld, C. D. Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am. J. Hum. Genet. 62, 950-961 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 950-961
-
-
Boehnke, M.1
Langefeld, C.D.2
-
38
-
-
0031912715
-
A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test
-
Spielman, R. S. & Ewens, W. J. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am. J. Hum. Genet. 62, 450-458 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 450-458
-
-
Spielman, R.S.1
Ewens, W.J.2
-
39
-
-
0032231911
-
Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease
-
Schaid, D. J. & Rowland, C. Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease. Am. J. Hum. Genet. 63, 1492-1506 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 1492-1506
-
-
Schaid, D.J.1
Rowland, C.2
-
40
-
-
0032897131
-
The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping
-
Teng, J. & Risch, N. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res. 9, 234-241 (1999).
-
(1999)
Genome Res.
, vol.9
, pp. 234-241
-
-
Teng, J.1
Risch, N.2
-
41
-
-
0033941557
-
Gamete competition models
-
Sinsheimer, J. S., Blangero, J. & Lange, K. Gamete competition models. Am. J. Hum. Genet. 66, 1168-1172 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 1168-1172
-
-
Sinsheimer, J.S.1
Blangero, J.2
Lange, K.3
-
42
-
-
0032539537
-
Mapping a disease locus by allelic association
-
Collins, A. & Morton, N. E. Mapping a disease locus by allelic association. Proc. Natl Acad. Sci. USA 95, 1741-1745 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 1741-1745
-
-
Collins, A.1
Morton, N.E.2
-
43
-
-
0030586840
-
Disequilibrium mapping: Composite likelihood for pairwise disequilibrium
-
Devlin, B., Risch, N. & Reeder, K. Disequilibrium mapping: composite likelihood for pairwise disequilibrium. Genomics 36, 1-16 (1996).
-
(1996)
Genomics
, vol.36
, pp. 1-16
-
-
Devlin, B.1
Risch, N.2
Reeder, K.3
-
44
-
-
0028834034
-
Likelihood methods for locating disease genes in non-equilibrium populations
-
Kaplan, N. L. Hill, W. G. & Weir, B. S. Likelihood methods for locating disease genes in non-equilibrium populations. Am. J. Hum. Genet. 56, 18-32 (1995).
-
(1995)
Am. J. Hum. Genet.
, vol.56
, pp. 18-32
-
-
Kaplan, N.L.1
Hill, W.G.2
Weir, B.S.3
-
45
-
-
0031933164
-
A conditional inference framework for extending the transmission/disequilibrium test
-
Lazzeroni, L. C. & Lange, K. A conditional inference framework for extending the transmission/disequilibrium test. Hum. Hered. 48, 67-81 (1998).
-
(1998)
Hum. Hered.
, vol.48
, pp. 67-81
-
-
Lazzeroni, L.C.1
Lange, K.2
-
46
-
-
0033358667
-
Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine scale genetic mapping
-
McPeek, M. S. & Strahs, A. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine scale genetic mapping. Am. J. Hum. Genet. 65, 858-875 (1999).
-
(1999)
Am. J. Hum. Genet.
, vol.65
, pp. 858-875
-
-
McPeek, M.S.1
Strahs, A.2
-
47
-
-
0031911190
-
Likelihood analysis of disequilibrium mapping, and related problems
-
Rannala, B. & Slatkin, M. Likelihood analysis of disequilibrium mapping, and related problems. Am. J. Hum. Genet. 62, 459-473 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 459-473
-
-
Rannala, B.1
Slatkin, M.2
-
48
-
-
0028968329
-
A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci
-
Terwilliger, J. D. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am. J. Hum. Genet. 56, 777-787 (1995).
-
(1995)
Am. J. Hum. Genet.
, vol.56
, pp. 777-787
-
-
Terwilliger, J.D.1
-
49
-
-
0030994211
-
Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications
-
Xiong, M. & Guo, S. W. Fine-scale genetic mapping based on linkage disequilibrium: theory and applications. Am. J. Hum. Genet. 60, 1513-1531 (1997).
-
(1997)
Am. J. Hum. Genet.
, vol.60
, pp. 1513-1531
-
-
Xiong, M.1
Guo, S.W.2
-
50
-
-
0000874908
-
Linkage analysis in the presence of errors IV: Joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified
-
Göring, H. H. H. & Terwilliger, J. D. Linkage analysis in the presence of errors IV: Joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. Am. J. Hum. Genet. 66, 1310-1327 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 1310-1327
-
-
Göring, H.H.H.1
Terwilliger, J.D.2
-
51
-
-
0027145633
-
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
-
Leach, F. S. et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75, 1215-1225 (1993).
-
(1993)
Cell
, vol.75
, pp. 1215-1225
-
-
Leach, F.S.1
-
52
-
-
0028221943
-
Mutation in the DNA mismatch pair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
-
Bronner, C. E. et al. Mutation in the DNA mismatch pair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368, 258-261 (1994).
-
(1994)
Nature
, vol.368
, pp. 258-261
-
-
Bronner, C.E.1
-
53
-
-
0031790040
-
Use of isolated inbred human populations for identification of disease genes
-
Sheffield, V. C., Stone, E. M. & Carmi, R. Use of isolated inbred human populations for identification of disease genes. Trends Genet. 14, 391-396 (1998).
-
(1998)
Trends Genet.
, vol.14
, pp. 391-396
-
-
Sheffield, V.C.1
Stone, E.M.2
Carmi, R.3
-
54
-
-
17344367913
-
Genome wide scan of multiple sclerosis in Finnish multiplex families
-
Kuokkanen, S. et al. Genome wide scan of multiple sclerosis in Finnish multiplex families. Am. J. Hum. Genet. 61, 1379-1387 (1997).
-
(1997)
Am. J. Hum. Genet.
, vol.61
, pp. 1379-1387
-
-
Kuokkanen, S.1
-
55
-
-
17444436401
-
The genetics of multiple sclerosis: Principles, background and updated results of the United Kingdom systematic genome screen
-
Chataway, J. et al. The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen. Brain 121, 1869-1887 (1998).
-
(1998)
Brain
, vol.121
, pp. 1869-1887
-
-
Chataway, J.1
-
56
-
-
0031916999
-
Mapping a gene for combined hyperlipidemia in a mutant mouse strain
-
Castellani, L. W. et al. Mapping a gene for combined hyperlipidemia in a mutant mouse strain. Nature Genet. 18, 374-377 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 374-377
-
-
Castellani, L.W.1
-
57
-
-
0033984185
-
Support for linkage of familial combined hypertipidemia to chromosome 1q21-q23 in Chinese and German families
-
Pei, W. et al. Support for linkage of familial combined hypertipidemia to chromosome 1q21-q23 in Chinese and German families. Clin. Genet. 57, 29-34 (2000).
-
(2000)
Clin. Genet.
, vol.57
, pp. 29-34
-
-
Pei, W.1
-
58
-
-
0033362160
-
Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels
-
Pajukanta, P. et al. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. Am. J. Hum. Genet. 64, 1453-1463 (1999).
-
(1999)
Am. J. Hum. Genet.
, vol.64
, pp. 1453-1463
-
-
Pajukanta, P.1
-
59
-
-
0031966959
-
Multipoint quantitative-trait linkage analysis in general pedigrees
-
Almasy, L. & Blangero, J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62, 1198-1211 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 1198-1211
-
-
Almasy, L.1
Blangero, J.2
-
60
-
-
0028058128
-
Robust variance-components approach for assessing genetic linkage in pedigrees
-
Amos, C. I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54, 535-543 (1994).
-
(1994)
Am. J. Hum. Genet.
, vol.54
, pp. 535-543
-
-
Amos, C.I.1
-
61
-
-
0031442937
-
Multipoint oligenic linkage analysis of quantitative traits
-
Blangero, J. & Almasy, L. Multipoint oligenic linkage analysis of quantitative traits. Genet. Epidemiol. 14, 959-964 (1997).
-
(1997)
Genet. Epidemiol.
, vol.14
, pp. 959-964
-
-
Blangero, J.1
Almasy, L.2
-
62
-
-
0025245437
-
Multipoint analysis of human quantitative genetic variation
-
Goldar, D. E. Multipoint analysis of human quantitative genetic variation. Am. J. Hum. Genet. 47, 957-967 (1990).
-
(1990)
Am. J. Hum. Genet.
, vol.47
, pp. 957-967
-
-
Goldar, D.E.1
-
63
-
-
0019920786
-
Extensions to multivariate normal models for pedigree analysis
-
Hoppers, J. L. & Mathews, J. D. Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet. 46, 373-383 (1982).
-
(1982)
Ann. Hum. Genet.
, vol.46
, pp. 373-383
-
-
Hoppers, J.L.1
Mathews, J.D.2
-
64
-
-
0027362259
-
Extended multipoint identity-by-descent analysis of human quantitative traits: Efficiency, power, and modeling considerations
-
Schork, N. J. Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am. J. Hum. Genet. 53. 1306-1319 (1993).
-
(1993)
Am. J. Hum. Genet.
, vol.53
, pp. 1306-1319
-
-
Schork, N.J.1
-
65
-
-
0034617236
-
Fw2.2: A quantitative trait locus key to the evolution of tomato fruit size
-
Frary, A. et al. fw2.2: A quantitative trait locus key to the evolution of tomato fruit size. Science 289, 85-88 (2000). A landmark publication reporting the isolation of a quantitative trait locus gene by positional cloning.
-
(2000)
Science
, vol.289
, pp. 85-88
-
-
Frary, A.1
-
66
-
-
0033869708
-
Linkage disequilibrium in isolated populations: Finland and a young subpopulation of Kuusamo
-
in the press
-
Varilo, T. et al. Linkage disequilibrium in isolated populations: Finland and a young subpopulation of Kuusamo. Eur. J. Hum. Genet. (in the press).
-
Eur. J. Hum. Genet.
-
-
Varilo, T.1
-
67
-
-
20244378207
-
Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland
-
Helgason, A. et al. Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland. Am. J. Hum. Genet. 67, 697-717 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 697-717
-
-
Helgason, A.1
-
68
-
-
13344260701
-
A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish
-
Ginns, E. I. et al. A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nature Genet. 12, 431-435 (1996).
-
(1996)
Nature Genet.
, vol.12
, pp. 431-435
-
-
Ginns, E.I.1
-
69
-
-
13044281675
-
A high-density genome scan detects evidence for a biopolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2
-
Detera-Wadleigh, S. et al. A high-density genome scan detects evidence for a biopolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc. Natl Acad. Sci. USA 96, 5604-5609 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 5604-5609
-
-
Detera-Wadleigh, S.1
-
70
-
-
7344248546
-
Collaborative study on the genetics of asthma. Genome-wide search for asthma susceptibility loci in a founder population
-
Ober, C. et al. Collaborative study on the genetics of asthma. Genome-wide search for asthma susceptibility loci in a founder population. Hum. Mol. Genet. 7, 1393-1398 (1998).
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1393-1398
-
-
Ober, C.1
-
71
-
-
0033759713
-
A second-generation genomewide screen for asthma-suspectibility alleles in a founder population
-
Ober, C., Tsalenko, A., Parry, R. & Cox, N. J. A second-generation genomewide screen for asthma-suspectibility alleles in a founder population Am. J. Hum. Genet. 67, 1154-1162 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 1154-1162
-
-
Ober, C.1
Tsalenko, A.2
Parry, R.3
Cox, N.J.4
-
72
-
-
0030903861
-
A genome-wide search for asthma susceptibility loci in ethnically diverse populations
-
Marsh, D. G. et al. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nature Genet. 15, 389-392 (1997).
-
(1997)
Nature Genet.
, vol.15
, pp. 389-392
-
-
Marsh, D.G.1
-
73
-
-
0032231322
-
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
-
Hanson, R. L. et al. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am. J. Hum. Genet. 63, 1130-1138 (1998). Shows the power of the quantitative trait locus strategy and the quantitation of phenotypes for the identification of disease susceptibility loci.
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 1130-1138
-
-
Hanson, R.L.1
-
74
-
-
0032910599
-
A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
-
Elbein, S., Hoffman, M., Teng, K., Leppert, M. & Hasstect, S. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 48, 1175-1182 (1999).
-
(1999)
Diabetes
, vol.48
, pp. 1175-1182
-
-
Elbein, S.1
Hoffman, M.2
Teng, K.3
Leppert, M.4
Hasstect, S.5
-
75
-
-
0033764737
-
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to Type 2 diabetes
-
Ghosh, S. et al. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to Type 2 diabetes. Am. J. Hum. Genet. 67, 1174-1185 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 1174-1185
-
-
Ghosh, S.1
-
76
-
-
0028249690
-
A non-syndromic form of neurosensory, recessive deafness maps to the pericentromeric region of chromosome 13q
-
Guilford, P. et al. A non-syndromic form of neurosensory, recessive deafness maps to the pericentromeric region of chromosome 13q. Nature Genet. 6, 24-28 (1994).
-
(1994)
Nature Genet.
, vol.6
, pp. 24-28
-
-
Guilford, P.1
-
77
-
-
0029162902
-
Nonsyndromic autosomal recessive deafness is linked to the DFNBI locus in a large inbred Bedouin family from Israel
-
Scott, D. A. et al. Nonsyndromic autosomal recessive deafness is linked to the DFNBI locus in a large inbred Bedouin family from Israel. Am. J. Hum. Genet. 57, 965-968 (1995).
-
(1995)
Am. J. Hum. Genet.
, vol.57
, pp. 965-968
-
-
Scott, D.A.1
-
78
-
-
0031007349
-
Connexin 26 mutations in hereditary nonsyndromic sensorineural deafness
-
Kelsell, D.P. et al. Connexin 26 mutations in hereditary nonsyndromic sensorineural deafness. Nature 387, 80-83 (1997).
-
(1997)
Nature
, vol.387
, pp. 80-83
-
-
Kelsell, D.P.1
-
79
-
-
0033364825
-
A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation suggesting multiple susceptibility loci
-
Hovatta, I. et al. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation suggesting multiple susceptibility loci. Am. J. Hum. Genet. 65, 1114-1124 (1999).
-
(1999)
Am. J. Hum. Genet.
, vol.65
, pp. 1114-1124
-
-
Hovatta, I.1
-
80
-
-
0034724924
-
Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22
-
Brzustowicz, L. M., Hodgkinson, K. A., Chow, E. W. C., Honer, W. G. & Bassett A. S. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288, 678-682 (2000).
-
(2000)
Science
, vol.288
, pp. 678-682
-
-
Brzustowicz, L.M.1
Hodgkinson, K.A.2
Chow, E.W.C.3
Honer, W.G.4
Bassett, A.S.5
-
81
-
-
0030017175
-
A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2
-
Kuokkanen, S. et al. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nature Genet. 13, 477-480 (1996).
-
(1996)
Nature Genet.
, vol.13
, pp. 477-480
-
-
Kuokkanen, S.1
-
82
-
-
15844368830
-
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
-
Sawcer, S. et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genet. 13, 444-468 (1996).
-
(1996)
Nature Genet.
, vol.13
, pp. 444-468
-
-
Sawcer, S.1
-
83
-
-
0031916999
-
Mapping a gene for combined hyperlipidemia in a mutant mouse strain
-
Castellani, L. W. et al. Mapping a gene for combined hyperlipidemia in a mutant mouse strain. Nature Genet. 18, 374-377 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 374-377
-
-
Castellani, L.W.1
-
84
-
-
0033984185
-
Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families
-
Pei, W. et al. Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families. Clin. Genet. 57, 29-34 (2000).
-
(2000)
Clin. Genet.
, vol.57
, pp. 29-34
-
-
Pei, W.1
-
85
-
-
0028871785
-
An international two-stage genome-wide search for schizophrenia susceptibility genes
-
Moises, H. W. et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genet. 11, 321-324 (1995).
-
(1995)
Nature Genet.
, vol.11
, pp. 321-324
-
-
Moises, H.W.1
-
86
-
-
0028820161
-
A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity
-
Straub, R. E. et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genet. 11, 287-293 (1995).
-
(1995)
Nature Genet.
, vol.11
, pp. 287-293
-
-
Straub, R.E.1
-
87
-
-
17944393918
-
Genome scan of schizophrenia
-
Levinson, D. F. et al. Genome scan of schizophrenia. Am. J. Psychiatry 155, 741-750 (1998).
-
(1998)
Am. J. Psychiatry
, vol.155
, pp. 741-750
-
-
Levinson, D.F.1
-
88
-
-
0000009909
-
Major suscpetibility locus for prostate cancer on chromosome 1 suggested by a genome wide search
-
Smith, J. R. et al. Major suscpetibility locus for prostate cancer on chromosome 1 suggested by a genome wide search. Science 274, 1371-1374 (1996).
-
(1996)
Science
, vol.274
, pp. 1371-1374
-
-
Smith, J.R.1
-
89
-
-
17344367365
-
Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43
-
Berthon, P. Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43. Am. J. Hum. Genet. 62, 1416-1424 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 1416-1424
-
-
Berthon, P.1
-
90
-
-
0033911539
-
Combined analysis of hereditary prostate cancer linkage to 1q24-25. Results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics
-
Xu, J. et al. Combined analysis of hereditary prostate cancer linkage to 1q24-25. Results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. Am. J. Hum. Genet. 66, 945-957 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 945-957
-
-
Xu, J.1
|