Low molecular weight indole fragments as IMPDH inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2535-2538

  Beevers, Rebekah E ^a   Buckley, George M ^a   Davies, Natasha ^a   Fraser, Joanne L ^a   Galvin, Francis C ^a   Hannah, Duncan R ^a   Haughan, Alan F ^a   Jenkins, Kerry ^a   Mack, Stephen R ^a   Pitt, William R ^a   Ratcliffe, Andrew J ^a   Richard, Marianna D ^a   Sabin, Verity ^a   Sharpe, Andrew ^a   Williams, Sophie C ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Fragment; IMPDH; Inosine monophosphate dehydrogenase

Indexed keywords

3 METHOXY 4 (OXAZOL 5 YL)ANILINE; ANILINE DERIVATIVE; BMS 337197; INDOLE DERIVATIVE; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; MERIMEPODIB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL SYMPTOM; HUMAN; IC 50; IN VITRO STUDY; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION;

CARBAMATES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROGEN BONDING; IMP DEHYDROGENASE; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; OXAZOLES; PHENYLUREA COMPOUNDS; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644986998     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.089     Document Type: Article

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