Preservation of mitochondrial function may contribute to cardioprotective effects of Na +/Ca 2+ exchanger inhibitors in ischaemic/reperfused rat hearts

British Journal of Pharmacology

Volumn 151, Issue 7, 2007, Pages 963-978

  Motegi, K ^a   Tanonaka, K ^a   Takenaga, Y ^a   Takagi, N ^a   Takeo, S ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Ischaemia; KB R7943; Mitochondria; Na + Ca 2+ exchanger; Oxidative phosphorylation; Reperfusion; SEA0400

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL FUNCTION; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VITRO STUDY; MALE; MITOCHONDRION; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RESPIRATORY FUNCTION; SODIUM TRANSPORT;

ADENOSINE TRIPHOSPHATE; ANILINE COMPOUNDS; ANIMALS; CALCIUM; CALCIUM CHLORIDE; CARDIOTONIC AGENTS; CREATINE KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; MALE; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NADP; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHENYL ETHERS; PHOSPHOCREATINE; RATS; RATS, WISTAR; SODIUM; SODIUM-CALCIUM EXCHANGER; TETRODOTOXIN; THIOUREA; VENTRICULAR FUNCTION, LEFT;

EID: 34547557663     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707321     Document Type: Article

References (39)

1. Bers DM (2002). Cardiac excitation-contraction coupling. Nature 415: 198-205.
2. 2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J Cardiovasc Pharmacol 21: 595-599.
3. 2+ in vivo. Biochem J 216: 333-342.
4. Dosono P, Mill JG, O'Neill SC, Eisner DA (1992). Fluorescence measurements of cytoplasmic and mitochondrial sodium concentration in rat ventricular myocytes. J Physiol (London) 448: 493-509.
5. 2+ exchange inhibition protects the rat heart from ischemia-reperfusion injury by blocking energy-wasting processes. Am J Physiol Heart Circ Physiol 288: H1699-H1707.
6. +-overload in ischemia and is cardioprotective. J Mol Cell Cardiol 31: 1985-1995.
7. 2+ binding site on the cytoplasmic side of the inner membrane. J Biol Chem 263: 1405-1412.
8. Iwai T, Tanonaka K, Inoue R, Kasahara S, Kamo N, Takeo S (2002a). Mitochondrial damage during ischemia determines postischaemic contractile dysfunction in perfused rat heart. J Mol Cell Cardiol 34: 725-738.
9. Iwai T, Tanonaka K, Inoue R, Kasahara S, Motegi K, Nagaya S et al. (2002b). Sodium accumulation during ischemia induces mitochondrial damage in perfused rat hearts. Cardiovasc Res 55: 141-149.
10. Iwai T, Tanonaka K, Motegi K, Inoue R, Kasahara S, Takeo S (2002c). Nicorandil preserves mitochondrial function during ischemia in perfused rat heart. Eur J Pharmacol 446: 119-127.
11. 2+ exchange in cells expressing NCX1. J Biol Chem 271: 22391-22397.
12. + in isolated heart mitochondria estimated using a fluorescent probe. Am J Physiol Cell Physiol 262: C1047-C1055.
13. Kleyman TR, Gragoe EJ (1988). Amiloride and its analogues as tools in the study of ion transport. J Member Biol 105: 1-21.
14. Liu J-X, Tanonaka K, Takeo S (1993). Beneficial effects of quinidine on postischemic contractile failure of isolated rat hearts. J Mol Cell Cardiol 25: 1249-1263.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the folin phenol reagent. J Biol Chem 261: 6300-6306.
16. 2+ exchanger inhibitors SEA0400 and KB-R7943. Am J Physiol Heart Circ Physiol 284: H903-H910.
17. 2+ exchanger, attenuated reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther 298: 249-256.
18. + exchanger for protection of the myocardium from lethal reperfusion injury. Cardiovasc Drugs Ther 16: 295-301.
19. Meng HP, Pierce GN (1991). Involvement of sodium in the protective effect of 5-(N,N-dimethyl)-amiloride on ischemia-reperfusion injury in isolated rat ventricular wall. J Pharmacol Exp Ther 258: 772-777.
20. 2+. Circ Res 68: 1250-1258.
21. 2+ exchange inhibitor, on myocardial ischemia/reperfusion injury. Folia Pharmacol Jpn 111: 105-115.
22. Pierce GN, Czubryt MP (1995). The contribution of ionic imbalance to ischemia/reperfusion-induced injury. J Mol Cell Cardiol 27: 53-63.
23. 2+ exchanger in reoxygenation-induced cardiomyocyte injury. Cardiovasc Res 51: 241-250.
24. 2+ overload in ischaemic-reperfused rat hearts. Circ J 66: 390-396.
25. 2+ exchanger in mammalian cardiac myocytes. J Physiol 488: 623-631.
26. 2+ exchanger, on myocardial ischemia-reperfusion injuries. Eur J Pharmacol 458: 155-162.
27. Takeo S, Miyake K, Tanonaka K, Takagi N, Takagi K, Kishimoto K et al. (1996). Beneficial effect of nebracetam on energy metabolism after microsphere-induced embolism in rat brain. Arch Int Pharmacodyn 331: 232-245.
28. + channel blockade of class-I-type antiarrhythmic agents in postischaemic contractile recovery of isolated, perfused hearts. J Pharmacol Exp Ther 273: 1403-1409.
29. Takeo S, Tanonaka K, Iwai T, Motegi K, Hirota Y (2004). Preservation of mitochondrial function during ischemia as a possible mechanism for cardioprotection of diltiazem against ischemia/reperfusion injury. Biochem Pharmacol 67: 565-574.
30. Tanaka H, Nishimura K, Akikawa T, Hirayama W, Tanaka Y, Shigenobu K (2002). Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Eur J Pharmacol 135: 1096-1100.
31. 2+ exchange. Circ Res 65: 1045-1056.
32. Tanonaka K, Iwai T, Motegi K, Takeo S (2003). Effects of N-(2-mercaptopropionyl)-glycine on mitochondrial function in ischemic-reperfused heart. Cardiovasc Res 57: 416-425.
33. Tanonaka K, Kajiwara H, Kameda H, Takasaki A, Takeo S (1999). Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers. Eur J Pharmacol 372: 37-48.
34. + accumulation in the ischemic myocardium. Gen Pharmacol 34: 167-174.
35. + during myocardial ischemia: Consequences for postischemic recovery. J Mol Cell Cardiol 29: 85-96.
36. 2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol 119: 555-563.
37. Yabe K, Tanonaka K, Koshimizu M, Katsuno T, Takeo S (2000). A role of PKC in the improvement of energy metabolism in preconditioned heart. Basic Res Cardiol 95: 215-227.
38. 2+ exchanger, on stunned myocardium in anesthetized dogs. J Anesth 19: 124-130.
39. 2+ exchanger, on myocardial ischemiareperfusion injury in rats. J Pharmacol Sci 95: 196-202.