Beneficial effect of nebracetam on energy metabolism after microsphere-induced embolism in rat brain

Archives Internationales de Pharmacodynamie et de Therapie

Volumn 331, Issue 3, 1996, Pages 232-245

  Takeo, S ^a   Miyake, K ^a   Tanonaka, K ^a   Takagi, N ^a   Takagi, K ^a   Kishimoto, K ^a   Suzuki, M ^a   Katsuragi, A ^a   Goto, M ^a   Oshikawa, S ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID; NEBRACETAM FUMARATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN EMBOLISM; BRAIN ISCHEMIA; CONTROLLED STUDY; ENERGY METABOLISM; HIPPOCAMPUS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; ENERGY METABOLISM; INTRACRANIAL EMBOLISM AND THROMBOSIS; LACTIC ACID; MALE; MICROSPHERES; PHOSPHOCREATINE; PSYCHOTROPIC DRUGS; PYRROLIDINONES; RATS; RATS, WISTAR;

EID: 0030472250     PISSN: 00039780     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. CROWE, W., MAYEVSKY, A. and MELA, L. Ion transport and energy metabolism in brain. Neurol. Res. 3, 107-123 (1981).
2. FURLOW, T. W. and BASS, N. H. Arachidonate-induced cerebrovascular occlusion in the rat. Neurophysiology 26, 297-304 (1976).
3. GUTMAN, I. and WAHLFELD, A. W. L-( + )-Lactate. In: Bergmeyer, H. U. (Ed.). Methods in Enzymatic Analysis, pp. 1464-1468. Verlag Chemie, Weinheim, and Academic Press, New York, London, 2nd Ed. (1974).
4. KUPPLER, D. and DECKER, K. Glycogen. In: Bergmeyer, H. U. (Ed.). Methods in Enzymatic Analysis, pp. 11-18. Verlag Chemie, Weinheim, 3rd Ed. (1984).
5. 1-muscarinic receptors. Jap. J. Pharmacol. 52, 597-607 (1991).
6. KOGURE, K., BUSTO, R. and SCHEINBERG, P. Energy metabolites and water content in rat brain during the early stage of development of cerebral infarction. Brain 97, 103-114 (1979).
7. KOIZUMI, S., KATAOKA, Y., SHIGEMATSU, K., NIWA, M. and UEKI, S. Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neuronal damage using rat striatal slices. Jap. J. Pharmacol. 53, 175-183 (1990).
8. KUHN, F. J., SCHINGNITZ, G., LEHR, E., MONTAGNA, E., HINZEN, H. D. and GIACHETTI, A. Pharmacology of WEB 1881-FU, a central cholinergic agent, which enhances cognition and cerebral metabolism. Arch. int. Pharmacodyn. 292, 13-34 (1988).
9. MCGRAW, C. P. Experimental cerebral ischemia and hypoxia: Comparison of inhibitory and adaptive responses. Neurol. Res. 1, 51-63 (1978).
10. MIYAKE, K., TANONAKA, K., MINEMATSU, R., INOUE, K. and TAKEO, S. Possible therapeutic effect of naftidrofuryl oxalate on brain energy metabolism after microsphere-induced cerebral embolism. Brit. J. Pharmacol. 98, 389-396 (1989).
11. MIYAKE, K., TAGUCHI, T., TANONAKA, K., HORIGUCHI, T., TAKAGI, N. and TAKEO, S. Beneficial effects of naftidrofuryl oxalate on brain regional energy metabolism after microsphere-induced cerebral embolism. J. Pharmacol. exp. Ther. 260, 1058-1066 (1992).
12. MIYAKE, K., TANONAKA, K., NASA, Y., TAKAGI, N., TSUCHIYA, T., YOSHIZAWA, M., FUJIOKA, Y. and TAKEO, S. Effects of naftidrofuryl oxalate on microsphere-induced changes in tricarboxylic acid cycle intermediates of rats. Europ. J. Pharmacol. 235, 75-81 (1993).
13. MIYAKE, K., TAKAGI, N. and TAKEO, S. Effects of naftidrofuryl oxalate on microsphere embolism-induced decrease in regional blood flow of rat brain. Brit. J. Pharmacol. 112, 226-230 (1994).
14. NARITOMI, H. Experimental basis of multi-infarct dementia: Memory impairments in rodent models of ischemia. Alzheimer Dis. ass. Disord. 5, 103-111 (1991).
15. NARUMI, S., KIYOTA, Y. and NAGAOKA, A. Cerebral embolization impairs memory function and reduces cholinergic marker enzyme activities in various brain regions in rats. Phar-macol. Biochem. Behav. 24, 1729-1731 (1986).
16. OHJIMI, H., KUSHIKU, K., YAMADA, H., KUWAHARA, T., KOHNO, Y. and FURUKAWA, T. Increase of acetylcholine release by nebracetam in dog cardiac sympathetic ganglion. J. Pharmacol. exp. Ther. 268, 396-402 (1994).
17. OHNO, M., YAMAMOTO, T., KITAJIMA, I. and UEKI, S. WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task. Jap. J. Pharmacol. 54, 53-60 (1990).
18. PULSINELLI, W. A., WALDMAN, S., RAWLLINSON, D. and PLUM, F. Moderate hyperglycemia augments ischemic brain damage: A neuropathologic study in the rat. Neurology 32, 1239-1246 (1982).
19. REHNCRONA, S., ROSEN, I. and SIESJO, B. K. Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J. cerebr. Blood Flow Metab. 1, 297-311 (1981).
20. SANBE, A., TANONAKA, K., HANAOKA, Y., KATOH, T. and TAKEO, S. Regional energy metabolism of failing hearts following myocardial infarction. J. molec. cell. Cardiol. 25, 995-1013 (1993).
21. SHIBATA, S., KAMI-ISHI, Y., UEKI, S. and WATANABE, S. Neuroprotective effect of WEB 1881 FU (nebracetam) on an ischemia-induced deficit of glucose uptake in rat hippocampal and cerebral cortical slices and CA1 field potential in hippocampal slices. Jap. J. Pharmacol. 58, 243-250 (1992).
22. SIESJO, B. K. and NILSSON, N. The influence of arterial hypoxemia upon labile phosphates and upon extracellular and intracellular lactate and pyruvate concentrations in the rat brain. Scand. J. clin. Lab. Invest. 27, 83-96 (1971).
23. SIESJO, B. K., CARLSSON, C., HÄRGERDAL, M. and NORDSTRÖM, C. H. Brain metabolism in the critically ill. Crit. Care Med. 4, 283-294 (1976).
24. TAKEO, S., MIYAKE, K., MINEMATSU, R., TANONAKA, K. and KONISHI, M. In vitro effect of naftidrofuryl oxalate on cerebral mitochondria impaired by microsphere-induced embolism in rats. J. Pharmacol. exp. Ther. 248, 1207-1214 (1989).
25. TAKEO, S., TANONAKA, R., MIYAKE, K., TANONAKA, K., TAGUCHI, T., KAWAKAMI, K., ONO, M., HIRAMATSU, M. and OKANO, K. Naftidrofuryl oxalate improves impaired brain glucose metabolism after microsphere-induced cerebral embolism in rats. J. Pharmacol. exp. Ther. 257, 404-410 (1991a).
26. TAKEO, S., MIYAKE, K., TANONAKA, K., TANONAKA, R., TAGUCHI, T., OKANO, K., INDUE, K., OHGA, Y. and KISHIMOTO, Y. Time course changes in brain energy metabolism of the rat after microsphere-induced cerebral embolism. Jap. J. Pharmacol. 55, 197-209 (1991b).
27. TAKEO, S., TAGUCHI, T., TANONAKA, K., MIYAKE, K., HORIGUCHI, T., TAKAGI, N. and FUJIMORI, K. Sustained damage to energy metabolism of brain regions after microsphere embolism in rats. Stroke 23, 62-68 (1992).