SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 1, 2001, Pages 249-256

  Matsuda, Toshio ^a   Arakawa, Naohisa ^a   Takuma, Kazuhiro ^b   Kishida, Yoko ^a   Kawasaki, Yasushi ^a   Sakaue, Masaki ^a   Takahashi, Kenzo ^c   Takahashi, Teisuke ^c   Suzuki, Taizo ^c   Ota, Tomomi ^c   Hamano Takahashi, Akiko ^c   Onishi, Michihito ^c   Tanaka, Yu ^c   Kameo, Kazuya ^c   Baba, Akemichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

^c TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM); ALPHA ADRENERGIC RECEPTOR; ANILINE DERIVATIVE; CALCIUM CHANNEL; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; SODIUM CALCIUM EXCHANGE PROTEIN; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CELL CULTURE; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; REPERFUSION INJURY; SODIUM CALCIUM EXCHANGE;

ANILINE COMPOUNDS; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN ISCHEMIA; CALCIUM SIGNALING; CEREBRAL CORTEX; CORPUS STRIATUM; ION CHANNELS; ION TRANSPORT; PHENYL ETHERS; RATS; RATS, WISTAR; REPERFUSION INJURY; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 0034976176     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. 2+ entry in cultured neurons and astrocytes
2. + channel function in cerebral arterioles in piglets
3. Hydrogen peroxide mediates amyloid β protein toxicity
4. 4 receptor binding in rat focal ischemia
5. 2
6. Group I metabotropic glutamate receptors: Implications for brain diseases
7. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
8. Membrane association of active 5-lipoxygenase in resting cells. Evidence for novel regulation of the enzyme in the rat alveolar macrophage
9. Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
10. Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells
11. 2 and its role in brain tissue
12. + channel stimulated by arachidonic acid and polyunsaturated fatty acids
13. The colorimetric determination of phosphorus
14. Effects of a novel calcium antagonist, S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4(3-nitrophenyl)tieno [2,3-b]pyridine-5-carboxylate (S-312-d), on ischemic amino acid release and neuronal injury in stroke-prone spontaneously hypertensive rats
15. Sodium-calcium exchange: Recent advances
16. 2+ exchanger isoforms by divalent cations and isothiourea derivative
17. 2+ exchange in cells expressing NCX1
18. + exchange system in glial cell lines. Properties and activation by an hyperosmotic shock
19. Calcium modulation of inositol 1,4,5-trisphosphate-induced calcium release from neuroblastoma x glioma hybrid (NG108-15) microsomes
20. 1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model
21. Inhibitors of sodium-calcium exchange: Identification and development of probes of transport activity
22. 2 using radioactive substrate
23. Expression pattern of messenger RNAs for prestanoid receptors in glial cell cultures
24. Serum-deprivation induces cell death of rat cultured microglia accompanied with expression of Bax protein
25. The influence of pH on cellular calcium influx during ischemia
26. Nylon monofilament for intraluminal middle cerebral artery occlusion in rats
27. 2+ exchange inhibitor, on ischemic acute renal failure in rats
28. 2+ exchanger
29. 2+ exchanger
30. Specific inhibition of Na-Ca exchange function by antisense oligodeoxynucleotides
31. Reversible middle cerebral artery occlusion without craniectomy in rats
32. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivations: A perspective on the contributions of apoptosis and necrosis
33. +)-ATPase by insulin/insulin-like growth factor-I in cultured rat astrocytes
34. 2+ paradox-like injury of cultured rat astrocytes
35. 2+ exchanger: Physiology and pharmacology
36. 2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes
37. 2+ exchange inhibitor, on myocardial ischemia-reperfusion injury
38. Rat brain and liver phospholipase C: Resolution of two forms with different requirements for calcium
39. + exchange
40. 4: Role in transient central ischemia of gerbils
41. 2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion
42. 2+ exchanger isoforms in rat neuronal preparations: Different changes in their expression during postnatal development
43. Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors
44. Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic rats
45. + in the hippocampus during recovery from short-term, transient ischemia
46. 2+ exchanger knockdown by antisense oligodeoxynucleotides in arterial myocytes
47. 2+ exchange inhibitor KB-R7943
48. 2+ exchanger on calcium dynamics in cultured cardiac myocytes
49. T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway
50. 2+ reperfusian injury of cultured astrocytes: Roles of reactive oxygen species and NF-κB activation
51. 2+ exchanger
52. 2+ signaling in cultured rat astrocytes
53. Heat shock protects cultured rat astrocytes in a model of reperfusion injury
54. CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production
55. + channels as targets for neuroprotective drugs
56. Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats
57. 2+ outflow and entry in the rat pancreatic β-cell: Studies with antisense oligonucleotides
58. Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept?
59. Kinins and kinin receptors in the nervous system
60. 2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs
61. 2+ exchange current in guinea-pig cardiac ventricular cells
62. NCX1 Na/Ca exchanger inhibition by antisense oligonucleotides in mouse distal convoluted tubule cells
63. Stimulation of β2-adrenoceptors inhibits apoptosis in rat brain after transient forebrain ischemia