Prevention of Autoimmune Gastritis in Mice Requires Extra-Thymic T-Cell Deletion and Suppression by Regulatory T Cells

Gastroenterology

Volumn 133, Issue 2, 2007, Pages 547-558

  Read, Simon ^a   Hogan, Thea V ^a   Zwar, Tricia D ^a   Gleeson, Paul A ^a   van Driel, Ian R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; GASTRITIS; GENE DELETION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; REGULATORY T LYMPHOCYTE; THYMUS;

EID: 34547552590     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.05.050     Document Type: Article

References (45)

1. van Driel I.R., Read S., Zwar T.D., and Gleeson P.A. Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis. Curr Opin Immunol 17 (2005) 570-576
2. Toh B.H., van Driel I.R., and Gleeson P.A. Mechanisms of disease-Pernicious anemia. N Engl J Med 337 (1997) 1441-1448
3. +-ATPase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis. Gastroenterology 120 (2001) 377-386
4. Alderuccio F., Cataldo V., van Driel I.R., Gleeson P.A., and Toh B.H. Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice. Internat Immunol 12 (2000) 343-352
5. McHugh R.S., Shevach E.M., Margulies D.H., and Natarajan K. A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity. Eur J Immunol 31 (2001) 2094-2103
6. +-Adenosine triphosphatase β subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology 117 (1999) 605-618
7. Laurie K.L., van Driel I.R., Zwar T.D., Barrett S.P., and Gleeson P.A. Endogenous H/K ATPase beta-subunit promotes t cell tolerance to the immunodominant gastritogenic determinant. J Immunol 169 (2002) 2361-2367
8. Spicer Z., Miller M.L., Andringa A., Riddle T.M., Duffy J.J., Doetschman T., and Shull G.E. Stomachs of mice lacking the gastric H,K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J Biological Chem 275 (2000) 21555-21565
9. Mathis D., and Benoist C. Back to central tolerance. Immunity 20 (2004) 509-516
10. Kyewski B., Derbinski J., Gotter J., and Klein L. Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol 23 (2002) 364-371
11. Gotter J., Brors B., Hergenhahn M., and Kyewski B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med 199 (2004) 155-166
12. Allen S., Read S., DiPaolo R., McHugh R.S., Shevach E.M., Gleeson P.A., and van Driel I.R. Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells. J Immunol 175 (2005) 5759-5764
13. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., and Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 (2002) 1395-1401
14. Asano M., Toda M., Sakaguchi N., and Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subset. J Exp Med 184 (1996) 387-396
15. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25)-breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
16. + regulatory T cells and their therapeutic potential. Annu Rev Med 57 (2006) 381-402
17. Rudensky A.Y., and Campbell D.J. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med 203 (2006) 489-492
18. Rudge G., Gleeson P.A., and van Driel I.R. Control of immune responses by immunoregulatory T cells. Arch Immunol Ther Exp (Warsz) 54 (2006) 381-391
19. + immunoregulatory T cells. Immunol Cell Biol 84 (2006) 487-501
20. Silveira P.A., Baxter A.G., Cain W.E., and van Driel I.R. A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis. J Immunol 162 (1999) 5106-5111
21. Lyons A.B., and Parish C.R. Determination of lymphocyte division by flow cytometry. J Immunol Methods 171 (1994) 131-137
22. + Regulatory T cells inhibit the antigen-dependent expansion of self-reactive T cells in vivo. J Immunol 176 (2006) 1609-1617
23. Barrett S.P., Gleeson P.A., Desilva H., Toh B.H., and van Driel I.R. Interferon-gamma is required during the initiation of an organ-specific autoimmune disease. Eur J Immunol 26 (1996) 1652-1655
24. Martinelli T.M., van Driel I.R., Alderuccio F., Gleeson P.A., and Toh B.H. Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis. Gastroenterology 110 (1996) 1791-1802
25. Judd L.M., Gleeson P.A., Toh B.H., and van Driel I.R. Autoimmune gastritis results in disruption of gastric epithelial cell development. Am J Physiol Gastointest Liver Physiol 277 (1999) G209-G218
26. Franic T.V., Judd L.M., Nguyen N.V., Samuelson L.C., Loveland K.L., Giraud A.S., Gleeson P.A., and van Driel I.R. Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis. Am J Physiol Gastrointest Liver Physiol 287 (2004) G910-G918
27. Suri-Payer E., Amar A.Z., McHugh R., Natarajan K., Margulies D.H., and Shevach E.M. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur J Immunol 29 (1999) 669-677
28. + T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J Immunol 175 (2005) 7135-7142
29. + immunoregulatory T cells in the induction of autoimmune gastritis. Immunol Cell Biol 80 (2002) 567-573
30. Scheinecker C., McHugh R., Shevach E.M., and Germain R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med 196 (2002) 1079-1090
31. Davey G.M., Kurts C., Miller J.F., Bouillet P., Strasser A., Brooks A.G., Carbone F.R., and Heath W.R. Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med 196 (2002) 947-955
32. Lohr J., Knoechel B., Kahn E.C., and Abbas A.K. Role of B7 in T cell tolerance. J Immunol 173 (2004) 5028-5035
33. + T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J Exp Med 187 (1998) 1555-1564
34. + T cells persist in vivo following induction of peripheral tolerance. J Immunol 160 (1998) 4719-4729
35. + T cell tolerance induced by deletion and TCR revision. J Immunol 171 (2003) 6290-6296
36. Kim J., Rasmussen J., and Rudensky A. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8 (2006) 191-197
37. Williams L.M., and Rudensky A.Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8 (2007) 277-284
38. (+) regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol 168 (2002) 5979-5983
39. + Regulatory T cells modulate the T-cell and antibody responses in Helicobacter-infected BALB/c mice. Infection and Immunity 74 (2006) 3519-3529
40. Kretschmer K., Apostolou I., Hawiger D., Khazaie K., Nussenzweig M.C., and von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 6 (2005) 1219-1227
41. Knoechel B., Lohr J., Kahn E., Bluestone J.A., and Abbas A.K. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202 (2005) 1375-1386
42. + regulatory T cells. Blood 107 (2006) 1056-1062
43. + regulatory T cells in the regional lymph node. J Exp Med 202 (2005) 771-781
44. Taguchi O., and Nishizuka Y. Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J Exp Med 165 (1987) 146-156
45. +-adenosine triphosphatase in human gastric autoimmunity. J Exp Med 198 (2003) 1147-1156