Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells

Molecular Brain Research

Volumn 90, Issue 2, 2001, Pages 165-173

  Kawahara, Kohichi ^a   Gotoh, Tomomi ^b   Oyadomari, Seiichi ^b   Kajizono, Makoto ^a   Kuniyasu, Akihiko ^a   Ohsawa, Keiko ^c   Imai, Yoshinori ^c   Kohsaka, Shinichi ^c   Nakayama, Hitoshi ^a   Mori, Masataka ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Argininosuccinate synthetase; Cationic amino acid transporter; Citrulline NO cycle; Microglia; Nitric oxide; Nitric oxide synthase

Indexed keywords

AMINO ACID TRANSPORTER; ARGININE; ARGININOSUCCINATE SYNTHASE; BACTERIUM LIPOPOLYSACCHARIDE; CARRIER PROTEIN; CITRULLINE; GAMMA INTERFERON; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL STIMULATION; CELL STRAIN; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME INDUCTION; IMMUNOBLOTTING; MEDIATOR RELEASE; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMINO ACID TRANSPORT SYSTEMS, BASIC; ANIMALS; ANTINEOPLASTIC AGENTS; ARGININOSUCCINATE SYNTHASE; CARRIER PROTEINS; CELLS, CULTURED; CITRULLINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON TYPE II; KINETICS; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; RNA, MESSENGER;

BACTERIA (MICROORGANISMS); FELIS CATUS; MURINAE;

EID: 0035919172     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00100-0     Document Type: Article

References (48)

1. Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41
2. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
3. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis
4. Cytotoxicity of microglia
5. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains
6. L-arginine transport is increased in macrophages generating nitric oxide
7. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
8. Reactive nitrogen intermediates in human neuropathology: An overview
9. Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins
10. Species differences in the generation of reactive oxygen species by microglia
11. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
12. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
13. Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis
14. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
15. Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells
16. Microglia as mediators of inflammatory and degenerative diseases
17. Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells
18. Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis
19. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine
20. Induction of argininosuccinate synthetase in rat brain glial cells after striatal microinjection of immunostimulants
21. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
22. In vivo induction of inducible nitric oxide synthase by microinjection with interferon-gamma and lipopolysaccharide in rat hippocampus
23. Microglia: A sensor for pathological events in the CNS
24. Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma
25. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
26. Interferon-gamma plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus
27. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
28. Activation of microglial cells by beta-amyloid protein and interferon-gamma
29. Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot, immunoblot, and immunohistochemical analyses
30. Characterization of microglia isolated from a primary culture of embryonic rat brain by a simplified method
31. Functional roles of microglia in the brain
32. Sustained nitric oxide production in macrophages requires the arginine transporter CAT2
33. Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production
34. Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse
35. Molecular biology of mammalian plasma membrane amino acid transporters
36. Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide
37. Induction of cationic amino acid transport activity in mouse peritoneal macrophages by lipopolysaccharide
38. Transport of L-arginine in cultured glial cells
39. Argininosuccinate synthetase: Localization in astrocytes and role in the production of glial nitric oxide
40. Induction of nitric oxide synthase in glial cells
41. Transcriptional regulation of genes for ornithine cycle enzymes
42. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease
43. Complement and cytokine gene expression in cultured microglial derived from postmortem human brains
44. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
45. Macrophages can convert citrulline into arginine
46. Preparation of recombinant argininosuccinate synthetase and argininosuccinate lyase: Expression of the enzymes in rat tissues
47. Expression of citrulline-nitric oxide cycle in lipopolysaccharide and cytokine-stimulated rat astroglioma C6 cells
48. Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide