Aromatase expression in a human osteoblastic cell line increases in response to prostaglandin E2 in a dexamethasone-dependent fashion

Steroids

Volumn 72, Issue 9-10, 2007, Pages 686-692

  Watanabe, M ^a   Noda, M ^a   Nakajin, S ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Aromatase; Dexamethasone; Human; Osteoblastic cell line; Prostaglandin E2; SV HFO

Indexed keywords

AROMATASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEXAMETHASONE; ESTROGEN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2;

ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ESTROGEN SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; OSTEOBLAST; PROTEIN EXPRESSION; UPREGULATION;

AROMATASE; CELL LINE; DEXAMETHASONE; DINOPROSTONE; DRUG SYNERGISM; FORSKOLIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); PROTEIN KINASE INHIBITORS; RECEPTORS, PROSTAGLANDIN E; UP-REGULATION;

EID: 34547228157     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2007.05.006     Document Type: Article

References (29)

1. Raisz L.G., Pilbeam C.C., and Fall P.M. Prostaglandins: mechanisms of action and regulation of production in bone. Osteoporos Int 3 Suppl 1 (1993) 136-140
2. Richards J.A., Petrel T.A., and Brueggemeier R.W. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. J Steroid Biochem Mol Biol 80 (2002) 203-212
3. Watanabe M., and Nakajin S. Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R. J Endocrinol 180 (2004) 125-133
4. Bulun S.E., Zeitoun K.M., Takayama K., and Sasano H. Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance. J Mol Endocrinol 25 (2000) 35-42
5. Bulun S.E., Takayama K., Suzuki T., Sasano H., Yilmaz B., and Sebastian S. Organization of the human aromatase p450 (CYP19) gene. Semin Reprod Med 22 (2004) 5-9
6. Watanabe M., Ohno S., and Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Eur J Endocrinol 152 (2005) 619-624
7. Chiba H., Sawada N., Ono T., Ishii S., and Mori M. Establishment and characterization of a simian virus 40-immortalized osteoblastic cell line from normal human bone. Jpn J Cancer Res 84 (1993) 290-297
8. Eijken M., Hewison M., Cooper M.S., de Jong F.H., Chiba H., Stewart P.M., et al. 11β-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation. Mol Endocrinol 19 (2005) 621-631
9. Janssen J.M., Bland R., Hewison M., Coughtrie M.W., Sharp S., Arts J., et al. Estradiol formation by human osteoblasts via multiple pathways: relation with osteoblast function. J Cell Biochem 75 (1999) 528-537
10. Watanabe M., Simpson E.R., Pathirage N., Nakajin S., and Clyne C.D. Aromatase expression in the human fetal osteoblastic cell line SV-HFO. J Mol Endocrinol 32 (2004) 533-545
11. Suzawa T., Miyaura C., Inada M., Maruyama T., Sugimoto Y., Ushikubi F., et al. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141 (2000) 1554-1559
12. Narumiya S., and FitzGerald G.A. Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 108 (2001) 25-30
13. Moroni M., Veronese S., Schiavo R., Carminati O., Sorensen B.S., Gambacorta M., et al. Epidermal growth factor receptor expression and activation in nonseminomatous germ cell tumors. Clin Cancer Res 7 (2001) 2770-2775
14. 2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. J Clin Endocrinol Metab 88 (2003) 2810-2816
15. Schlotzer-Schrehardt U., Zenkel M., and Nusing R.M. Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues. Invest Ophthalmol Vis Sci 43 (2002) 1475-1487
16. 2 downregulates interleukin-12 production through EP4 receptors in human monocytes stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans and interferon-gamma. Oral Microbiol Immunol 18 (2003) 150-155
17. Maffei L., Murata Y., Rochira V., Tubert G., Aranda C., Vazquez M., et al. Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment. J Clin Endocrinol Metab 89 (2004) 61-70
18. Bilezikian J.P., Morishima A., Bell J., and Grumbach M.M. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339 (1998) 599-603
19. Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337 (1997) 91-95
20. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., and Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80 (1995) 3689-3698
21. 2-mediated bone resorption associated with inflammation. J Exp Med 197 (2003) 1303-1310
22. 2 and bone resorption by recombinant human interleukin 1α in fetal mouse bones. Biochem Biophys Res Commun 138 (1986) 618-624
23. Suda T., Takahashi N., and Martin T.J. Modulation of osteoclast differentiation. Endocr Rev 13 (1992) 66-80
24. 2 on the growth and differentiation of osteoblast-like cells cultured in vitro. Int J Mol Med 10 (2002) 451-456
25. Canalis E. Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae. Endocrinology 112 (1983) 931-939
26. Coleman R.A., Smith W.L., and Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46 (1994) 205-229
27. Breyer R.M., Bagdassarian C.K., Myers S.A., and Breyer M.D. Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41 (2001) 661-690
28. Shozu M., and Simpson E.R. Aromatase expression of human osteoblast-like cells. Mol Cell Endocrinol 139 (1998) 117-129
29. Penuelas I., Encio I.J., Lopez-Moratalla N., and Santiago E. cAMP activates transcription of the human glucocorticoid receptor gene promoter. J Steroid Biochem Mol Biol 67 (1998) 89-94