Prostaglandin E2 downregulates interleukin-12 production through EP4 receptors in human monocytes stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans and interferon-γ

Oral Microbiology and Immunology

Volumn 18, Issue 3, 2003, Pages 150-155

  Iwasaki, K ^a   Noguchi, K ^a   Endo, H ^b   Kondo, H ^b   Ishikawa, I ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

EP4 receptor; Interleukin 12; Lipopolysaccharide; Monocytes; Prostaglandin E2

Indexed keywords

11 DEOXYPROSTAGLANDIN E1; ADENYLATE CYCLASE; BACTERIUM LIPOPOLYSACCHARIDE; BUTAPROST; CYCLIC AMP; FORSKOLIN; GAMMA INTERFERON; INDOMETACIN; INTERLEUKIN 12; MESSENGER RNA; ONO AP 324; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; EP4 RECEPTOR; LIPOPOLYSACCHARIDE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ARTICLE; BACTERIAL INFECTION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MONOCYTE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; CELLS, CULTURED; CYCLIC AMP; DINOPROSTONE; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MONOCYTES; RECEPTORS, PROSTAGLANDIN E; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0038240904     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-302X.2003.00046.x     Document Type: Article

References (55)

1. 2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry 1994: 33: 14496-14502.
2. 2. Biochem Biophys Res Commun 1993: 197: 263-270.
3. Aoyagi T, Sugawara-Aoyagi M, Yamazaki K, Hara K. Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissue in periodontitis patients with high serum antibody titers to Porphyromonas gingivalis. Oral Microbiol Immunol 1995: 10: 304-310.
4. 2 receptor subtype 4 mRNA in mononuclear Jurkat and KM-3 cells and coexpression of subtype 4 and 2 mRNA in U-937 cells. FEBS Lett 1996: 394: 39-43.
5. Brunda MJ. Interleukin-12. J Leukoc Biol 1994: 55: 280-288.
6. Cassatella MA, Meda L, Gasperini S, D'Andrea A, Ma X, Trinchieri G. Interleukin-12 production by human polymorphonuclear leukocytes. Eur J Immunol 1995: 25: 1-5.
7. Chehimi J, Starr SE, Frank I, et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994: 179: 1361-1366.
8. Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 1994: 46: 205-229.
9. Cox FE, Liew FY. T-cell subsets and cytokines in parasitic infections. Immunol Today 1992: 13: 445-448.
10. 2, thromboxane, and prostacyclin in periodontal tissues. J Periodontal Res 1983: 18: 156-163.
11. Ebersole JL, Taubman MA. The protective nature of host responses in periodontal diseases. Periodontol 2000 1994: 5: 112-141.
12. Ellis SD, Tucci MA, Serio FG, Johnson RB. Factors for progression of periodontal diseases. J Oral Pathol Med 1998: 27: 101-105.
13. Fujihashi K, Kono Y, Yamamoto M, et al. Interleukin production by gingival mononuclear cells isolated from adult periodontitis patients. J Dent Res 1991: 70: 550 (abstr. 2269).
14. Fokkema SJ, Loos BG, Slegte C, van der Velden U. A type 2 response in lipopolysaccharide (LPS)-stimulated whole blood cell cultures from periodontitis patients. Clin Exp Immunol 2002: 127: 374-378.
15. + T cells isolated from inflamed human gingival tissues. Clin Exp Immunol 1996: 103: 422-428.
16. Gemmell E, Marshall RI, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 1997: 14: 112-143.
17. Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are detemined by the nature of the lymphocytic response. Crit Rev Oral Biol Med. 2002: 13: 17-34.
18. Gubler U, Chua AO, Schoenhaut DS, et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 1991: 88: 4143-4147.
19. Hayes MP, Wang J, Norcross MA. Regulation of interleukin-12 expression in human monocytes: selective priming by interferonγ of lipopolysaccharide-inducible p35 and p40 genes. Blood 1995: 86: 646-650.
20. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993: 260: 547-549.
21. Iino Y, Hopps RM. The bone-resorbing activities in tissue culture of lipopolysaccharides from the bacteria Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Capnocytophaga ochracea isolated from human mouths. Arch Oral Biol 1984: 29: 59-63.
22. 3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur J Biochem 1993: 217: 313-318.
23. Jakob T, Huspith BN, Latchman YE, Rycroft R, Brostoff J. Depressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis. Clin Exp Immunol 1990: 79: 380-384.
24. 4 prostaglandin E receptors in mouse macrophage-like cell line, J774. 1. Biochem Biophys Res Commun 1998: 251: 727-731.
25. 2 subtype: cloning, expression, and northem blot analysis. FEBS Lett 1995: 372: 151-156.
26. Kimmel AR, Berger SL. Preparation of cDNA and the generation of cDNA libraries: overview. Methods Enzymol 1987: 152: 307-316.
27. 3 receptor subtype gene (PTGER3). Genomics 1997: 40: 425-434.
28. Lalli E, Sassone-Corsi P. Signal transduction and gene regulation: the nuclear response to cAMP. J Biol Chem 1994: 269: 17359-17362.
29. Lappin DF, MacLeod CP, Kerr A, Mitchell T, Kinane DF. Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clin Exp Immunol 2001: 123: 294-300.
30. Leung DY, Key L, Steinberg JJ, et al. Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome. J Immunol 1988: 140: 84-88.
31. Ma X, Aste-Amezaga M, Trinchieri G. Regulation of interleukin-12 production. Ann NY Acad Sci 1996: 795: 13-25.
32. Manetti R, Gerosa F, Giudizi MG, et al. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 1994: 179: 1273-1283.
33. 2 production by macrophages infected with HIV. Cell Immunol 1993: 152: 120-130.
34. 2 inhibits lipopolysaccharideinduced tumor necrosis factor-α generation. Br J Pharmacol 1997: 122: 149-157.
35. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation of interleukin 12 p40 expression through a NF-κ B half-site. Mol Cell Biol 1995: 15: 5258-5267.
36. 4 receptors positively coupled to adenylyl cyclase. Br J Pharmacol 1994: 113: 8P.
37. Mundy GR. Inflammatory mediators and the destruction of bone. J Periodontal Res 1991: 26: 213-217.
38. Negishi M, Sugimoto Y, Ichikawa A. Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1995: 1259: 109-119.
39. 4 subtypes downregulate tumor necrosis factor α-induced intercellular adhesion molecule-1 expression in human gingival fibroblasts. J Periodontal Res 1999: 34: 478-485.
40. Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol 1996: 1: 821-878.
41. Ollivier V, Parry GCN, Cobb RR, de Prost D, Mackman N. Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem 1996: 271: 20828-20835.
42. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 1991: 26: 230-242.
43. Pilon M, Williams-Miller C, Cox DS. Interleukin-2 levels in gingival crevicular fluid in periodontitis. J Dent Res 1991: 70: 550 (abstr. 2270).
44. 2 subtype. Mol Pharmacol 1994: 46: 213-220.
45. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today 1991: 12: 256-257.
46. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 1993: 90: 10188-10192.
47. 2, IL-1 β, IL-6, and TNF α by adherent mononuclear cells from early onset periodontitis patients. J Periodontol 1994: 65: 139-146.
48. Slots J, Bragd L, Wikstrom M, Dahlen G. The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adults. J Clin Periodontol 1986: 13: 570-577.
49. Snijders A, Hilkens CM, van der Pouw Kraan TC, Engel M, Aarden LA, Kapsenberg ML. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 1996: 156: 1207-1212.
50. Tokoro Y, Matsuki Y, Yamamoto T, Suzuki T, Hara K. Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. Clin Exp Immunol 1997: 107: 166-174.
51. Trinchieri G, Scott P. The role of interleukin 12 in the immune response, disease and therapy. Immunol Today 1994: 15: 460-463.
52. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994: 84: 4008-4027.
53. 2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995: 181: 775-779.
54. 1 subtype of prostaglandin E receptor. J Biol Chem 1993: 268: 20175-20178.
55. 2 receptors on U937 human monocytic cells. Immunology 1995: 86: 620-628.