Aromatase expression of human osteoblast-like cells

Molecular and Cellular Endocrinology

Volumn 139, Issue 1-2, 1998, Pages 117-129

  Shozu, Makio ^a   Simpson, Evan R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aromatase activity; Estrogen; Osteoblast like cells

Indexed keywords

ALKALINE PHOSPHATASE; ANDROSTENEDIONE; AROMATASE; COLECALCIFEROL; COMPLEMENTARY DNA; CYTOKINE; DEXAMETHASONE; ESTRONE; INTERLEUKIN 1BETA; MESSENGER RNA; ONCOSTATIN M; OSTEOCALCIN; TRITIUM; TUMOR NECROSIS FACTOR ALPHA; WATER;

ARTICLE; BONE MINERALIZATION; ENZYME ACTIVITY; ENZYME KINETICS; ESTROGEN SYNTHESIS; FETUS; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; LONG BONE; METAPHYSIS; OSTEOBLAST; PERIOSTEUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RADIOASSAY; RNA TRANSCRIPTION; THIN LAYER CHROMATOGRAPHY;

ALKALINE PHOSPHATASE; AROMATASE; CALCITRIOL; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DEXAMETHASONE; FETUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; HUMANS; KINETICS; MINERALS; OSTEOBLASTS; OSTEOCALCIN; PERIOSTEUM; PROMOTER REGIONS (GENETICS);

EID: 0032580276     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00069-0     Document Type: Article

References (49)

1. Ackerman G.E., Smith M.E., Mendelson C.R., MacDonald P.C., Simpson E.R. Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J. Clin. Endocrinol. Metab. 53:1981;412-417.
2. Agarwal V.R., Bulun S.E., Leitch M., Rohrich R., Simpson E.R. Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J. Clin. Endocrinol. Metab. 81:1996;3843-3849.
3. 3, parathyroid hormone, and glucocorticoids. Metab. Bone Dis. Relat. Res. 5:1984;32-34.
4. Bolander M.E. Regulation of fracture repair by growth factor. Proc. Soc. Exp. Biol. Med. 200:1997;165-170.
5. Bruch H.R., Wolf L., Budde R., Romalo G., Schweikert H.U. Androstenedione metabolism in cultured human osteoblast-like cells. J. Clin. Endocrinol. Metab. 75:1992;101-105.
6. Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., Korach K.S., Simpson E.R. Effect of testosterone and estradiol in a man with aromatase deficiency. New Engl. J. Med. 337:1997;91-95.
7. btsA58 transgenic mouse. Proc. Natl. Acad. Sci. USA. 90:1993;5578-5582.
8. Cooper J.A., Sefton B.M., Hunter T. Detection and quantification of phosphotyrosine. Methods Enzymol. 99:1983;387-402.
9. Crichton M.B., Nichols J.E., Zhao Y., Bulun S.E., Simpson E.R. Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells. Mol. Cell. Endocrinol. 118:1996;215-220.
10. Einhorn, T.A., Majeska, R.J., Rush, E.B., Levie, P.M., Horowitz, M.C., 1997. The Expression of Cytokine Activity by Fracture Callus.
11. Girasole G., Jilka R.L., Passeri G., Boswell S., Boder G., Williams D.C., Manolagas S.C. 17β-Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens. J. Clin. Invest. 89:1992;883-891.
12. Grodin J.M., Siiteri P.K., MacDonald P.C. Extraglandular estrogen in the postmenopause. Ryan K.J., Gibson D.C. Menopause and Aging. 1972;15-35 Government Printing Office, Washington, DC.
13. Harada N., Yamada K., Saito K., Kibe N., Dohmae S., Takagi Y. Structural characterization of the human estrogen synthetase (aromatase) gene. Biochem. Biophys. Res. Commun. 166:1990;365-372.
14. Harris S.A., Enger R.J., Riggs L., Spelsberg T.C. Development and charaterization of a conditionally immortalized human fetal osteoblastic cell line. J. Bone Miner. Res. 10:1995;178-186.
15. Horowitz M.C. Cytokines and estrogen in bone: anti-osteoporotic effects. Science. 260:1993;626-627.
16. Hotamisligil G.S., Shargil N.S., Spiegleman B.M. Adipose expression of tumor necrosis factor α: direct role in obesity-linked insulin resistance. Science. 259:1993;87-91.
17. Jakob F., Hormann D., Seufert J., Schneider D., Kohrle J. Expression and regulation of aromatase cytochrome P450 in THP-1 human myeloid leukemia cells. Mol. Cell. Endocrinol. 110:1995;27-33.
18. Jilka R.L., Hangoc G., Girasole G., Passeri G., Williams D.C., Abrams J.S., Boyce B., Broxmeyer H., Manolagas S.C. Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science. 257:1992;88-91.
19. Kashihara Y., Kawamara M., Oda H., Higaki S. In vitro calcification in human osteoblastic cell line derived from periosteum. Biochem. Biophys. Res. Commun. 145:1987;651-657.
20. Kilgore M.W., Means G.D., Mendelson C.R., Simpson E.R. Alternative promotion of aromatase cytochrome P450 expression in human fetal tissues. Mol. Cell. Endocrinol. 83:1992;R9-R16.
21. Lea, C.K., Ebrahim, H., Tennant, S., Flanagan, A.M. 1997. Aromatase cytochrome P450 transcripts are detected in fractured human bone but not in normal skeletal tissue. J. Clin. Endocrinol. Metab. (in press).
22. MacDonald P.C., Madden J.D., Brenner P.F., Wilson J.D., Siiteri P.K. Origin of estrogen in normal men and in women with testicular feminization. J. Clin. Endocrinol. Metab. 49:1979;905-916.
23. Mahendroo M.S., Mendelson C.R., Simpson E.R. Tissue-specific and hormonally-controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J. Biol. Chem. 268:1993;19463-19470.
24. Means G.D., Mahendroo M., Corbin C.J., Mathis J.M., Powell F.E., Mendelson C.R., Simpson E.R. Structural analysis of the gene encoding human aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem. 264:1989;19385-19391.
25. Means G.D., Kilgore M.W., Mahendroo M.S., Mendelson C.R., Simpson E.R. Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5:1991;2005-2013.
26. Mendelson C.R., Corbin C.J., Smith M.E., Smith J., Simpson E.R. Growth factors suppress, and phorbol esters potentiate the action of dibutyryl cyclic AMP to stimulate aromatase activity of human adipose stromal cells. Endocrinology. 118:1986;968-973.
27. Michalevicz R., Lifshitz D., Revel M. Interferon beta 2/interleukin 6 and interleukin-3 synergize in stimulating proliferation of human early hematopoetic progenitor cells. Scanning Microsc. 3:1989;1143-1150.
28. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 80:1995;3689-3698.
29. Nawata H., Tanaka S. et al. Aromatase in bone cells: association with osteoporosis in postmenopausal women. J. Steroid Biochem. Mol. Biol. 53:1995;165-174.
30. Nelson D.R., Kamataki T., Waxman D.J., Guengerich F.P., Estabrook R.W., Feyereisen R., Gonzalez F.J., Coon M.J., Gunsalus I.C., Gotoh O., Okuda K., Nebert D.W. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell. Biol. 12:1993;1-51.
31. Owen M. Lineage of osteogenic cells and their relationship to the stromal system. Bone Mineral Res. 3:1985;1-25.
32. Purohit A., Flanagan A.M., Reed M.J. Estrogen synthesis by osteoblast cell lines. Endocrinology. 131:1992;2027-2029.
33. Qin, K., Fisher, C.R., Simpson, E.R., Serpente, S., Faustini-Fustini, M., Carani, C., 1996. Oligospermia and persistent linear growth of a male subject caused by a missense mutation in the gene encoding aromatase. Proceedings of the IV International Aromatase Conference. Tahoe City, CA, p. 23.
34. Sabokbar A., Millett P.J., Myer B., Rushton N. A rapid, quantitative assay for measuring alkaline phosphatase activity in osteoblastic cells in vitro. Bone Miner. 27:1994;57-67.
35. Sasano, H., Uzuki, M., Sawai, T., Nagura, H., Harada, N., 1997. Aromatase in normal human bone tissue. Abstracts of the 79th Annual Meeting of the Endocrine Society. Minneapolis, MN, p. 239.
36. Sharpe K.L., Zimmer R.L., Griffin W.T., Penney L.L. Polypeptides synthesized and released by human endometriosis differ from those of the uterine endometrium in cell and tissue explant culture. Fertil. Steril. 60:1993;839-851.
37. Shozu, M., Simpson, E. 1997. Estrogen biosynthesis in THP-1 cells is regulated by promoter switching of the aromatase (CYP19) gene. Endocrinology (in press).
38. Shozu, M., Zhao, Y., Simpson, E.R. 1996. Regulation of aromatase activity in the THP-1 osteoclastic cell line. Abstracts of the V International Congress on Endocrinology. San Francisco, CA, p. 59.
39. Simpson E.R., Mahendroo M.S., Means G.D., Kilgore M.W., Hinshelwood M.M., Graham-Lorence S., Amarneh B., Ito Y., Fisher C.R., Michael M.D., Mendelson C.R., Bulun S.E. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr. Rev. 15:1994;342-355.
40. Smith E.P., Boyd J., Frank G.R., Takahashi H., Cohen R.M., Specker B., Williams T.C., Lubahn D.B., Korach K.S. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. New Engl. J. Med. 331:1994;1056-1061.
41. Tanaka S., Takahashi N., Udagawa N., Tamura T., Akatsu T., Stanley E.R., Kurokawa T., Suda T. Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J. Clin. Invest. 91:1993;257-263.
42. 3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts. Endocrinology. 137:1996;1860-1869.
43. Toda K., Terashima M., Kamamoto T., Sumimoto H., Yamamoto Y., Sagara Y., Ikeda H., Shizuta Y. Structural and functional characterization of human aromatase P450 gene. Eur. J. Biochem. 193:1990;559-565.
44. Toda K., Simpson E.R., Mendelson C.R., Shizuta Y., Kilgore M.W. Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues. Mol. Endocrinol. 8:1994;210-217.
45. Tsai-Morris C.H., Aquilana D.R., Dufau M.L. Gonadotropic regulation of aromatase activity in the adult rat testis. Endocrinology. 116:1985;31-37.
46. Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T. Cloning and expression of the human interleukin-6 (BSF-2/IFNβ 2) receptor. Science. 241:1988;825-828.
47. Zhao Y., Nichols J.E., Bulun S.E., Mendelson C.R., Simpson E.R. Aromatase P450 gene expression in human adipose tissue: Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J. Biol. Chem. 270:1995;16449-16457.
48. Zhao Y., Nichols J.E., Valdez R., Mendelson C.R., Simpson E.R. Tumor necrosis factor-α stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter I.4. Mol. Endocrinol. 10:1996a;1350-1357.
49. 2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase gene). Endocrinology. 150:1996b;S51-S57.