Estradiol formation by human osteoblasts via multiple pathways: Relation with osteoblast function

Journal of Cellular Biochemistry

Volumn 75, Issue 3, 1999, Pages 528-537

  Janssen, J M M F ^a   Bland, R ^b   Hewison, M ^b   Coughtrie, M W H ^c   Sharp, S ^c   Arts, J ^a   Pols, H A P ^a   Van Leeuwen, J P T M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

17 hydroxysteriod dehydrogenase; Androstenedione; Aromatase; Differentiation; Estrone; Sulfatase; Testosterone

Indexed keywords

ANDROSTENEDIONE; AROMATASE; ESTRADIOL; ESTROGEN; ESTRONE; ESTRONE SULFATE; ISOENZYME; MESSENGER RNA; STERYL SULFATASE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ARTICLE; BONE METABOLISM; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

17-HYDROXYSTEROID DEHYDROGENASES; ANDROSTENEDIONE; AROMATASE; ARYLSULFATASES; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DNA PRIMERS; ESTRADIOL; ESTRONE; HUMANS; OSTEOBLASTS; RNA, MESSENGER; STERYL-SULFATASE; TESTOSTERONE;

EID: 0033485478     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19991201)75:3<528::AID-JCB16>3.0.CO;2-3     Document Type: Article

References (30)

1. Adamski J, Normand T, Leenders F, Monte D, Begue A, Stehelin D, Jungblut PW, de Launoit Y. 1995. Molecular cloning of a novel widely expressed human 80KDa 17β-hydroxysteroid dehydrogenase IV. Biochem J 311:437-443.
2. Arts J, Kuiper GGJM, Janssen JMMF, Gustafsson J-A, Lowik CWGM, Pols HAP, Van Leeuwen JPTM. 1997. Differential expression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067-5070.
3. Bilezikian JP, Morishima A, Bell J, Grumbach MM. 1998. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339:599-603.
4. Biswas MG, Russell DW. 1997. Expression cloning and characterization of oxidative 17β-and 3β-hydroxysteroid dehydrogenases from rat and human prostate. J Biol Chem 272:15959-15966.
5. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorophorm extraction. Anal Biochem 162:156-159.
6. Coughtrie MWH, Sharp S, Maxwell K, Innes NP. 1998. Biology and function of the reversible sulfation pathway catalysed by sulfotransferases and sulfatases. Chem Biol Interact 109:3-27.
7. Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B, for the Study of Osteoporotic Fractures Research Group. 1998. Endogenous hormones and the risk of hip and vertebral fractures among older women. N Engl J Med 339:733-738.
8. Deyashiki Y, Ohshima K, Nakanishi M, Sato K, Matsuura K, Hara A. 1995. Molecular cloning and characterization of mouse estradiol 17β-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem 270: 10461-10467.
9. Dong Y, Qiu QQ, Debear J, Lathrop WF, Bertolini DR, Tamburini PP. 1998. 17-Beta-Hydroxysteroid dehydrogenases in human bone cells. J Bone Miner Res 13:1539-1546.
10. Eyre LJ, Bland R, Bujalska IJ, Sheppard MC, Stewart PM, Hewison M. 1998. Characterization of aromatase and 17β-hydroxysteroid dehydrogenase expression in rat osteoblastic cells. J Bone Miner Res 13:996-1004.
11. Fujikawa H, Okura F, Kuwano Y, Sekizawa A, Chiba H, Shimodaira K, Saito H, Yanaihara T. 1997. Steroid sulfatase activity in osteoblast cells. Biochem Biophys Res Commun 231:42-47.
12. Geissler WM, Davis DL, Wu L, Bradshaw KD, Patel S, Mendonca BB, Elliston KO, Wilson JD, Russell DW, Andersson S. 1994. Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3. Nature Genet 7:34-39.
13. Harada N, Utsumi T, Takagi Y. 1993. Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc Natl Acad Sci USA 90:11312-11316.
14. Horowitz MC. 1993. Cytokines and estrogen in bone: anti-ostoporotic effects. Science 260:626-627.
15. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. 1992. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-92.
16. Kawaguchi H, Pilbeam CC, Vargas SJ, Morse EE, Lorenzo JA, Raisz LG. 1995. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. J Clin Invest 96:539-548.
17. Lea CK, Ebrahim H, Tennant S, Flanagan AM. 1997. Aromatase cytochrome P450 transcripts are detected in fractured human bone but not in normal skeletal tissue. Bone 21:433-440.
18. Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM. 1998. Expression and characterization of recombinant type 2 3alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3alpha/17beta-HSD activity and cellular distribution. Mol Endocrinol 11:1971-1984.
19. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. 1995. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80:3689-3698.
20. Nawata H, Tanaka S, Tanaka S, Takayanagi R, Sakai Y, Yanase T, Ikuyama S, Haji M. 1995. Aromatase in bone cell: association with osteoporosis in postmenopausal women. J Steroid Biochem Mol Biol 53:165-174.
21. Peltoketo H, Isomaa V, Poutanen M, Vihko R. 1996. Expression and regulation of 17β-hydroxysteroid dehydrogenase IV. Biochem J 311:437-443.
22. 3 on growth, alkaline phosphatase and adenylate cyclase of rat osteoblast-like cells. Bone Mineral 1:397-405.
23. Purohit A, Flanagan AM, Reed MJ. 1992. Estrogen synthesis by osteoblast cell lines. Endocrinology 131:2027-2029.
24. Sasano H, Uzuki M, Sawai T, Nagura H, Matsunaga G, Kashimoto O, Harada N. 1997. Aromatase in human bone tissue. J Bone Miner Res 12:1416-1423.
25. Schweikert H-U, Wolf L, Romalo G. 1995. Estrogen formation from androstenedione in human bone. Clin Endocrinol 43:37-42.
26. Stein GS, Lian JB. 1993. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14:424-442.
27. 3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts. Endocrinology 137:1860-1869.
28. Tetsuka M, Milne M, Hillier SG. 1998. Expression of estrogen receptor isoforms in relation to enzymes of estrogen synthesis in rat ovary. Mol Cel Endocrinol 141:29-35.
29. Toda K, Simpson ER, Mendelson CR, Shizuta Y, Kilgore MW. 1994. Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues. Mol Endocrinol 8:210-217.
30. Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S. 1993. Expression cloning and characterisation of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. J Biol Chem 268: 12964-12969.