Our cells get stressed too! Implications for human disease

Blood Cells, Molecules, and Diseases

Volumn 39, Issue 2, 2007, Pages 148-150

  Kastan, Michael B ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

ATM; Cancer; DNA damage; Metabolic syndrome; p53

Indexed keywords

ATM PROTEIN;

ARTICLE; CANCER GENETICS; CANCER SUSCEPTIBILITY; CELL STRESS; DNA DAMAGE; DNA STRAND BREAKAGE; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL;

CELL CYCLE PROTEINS; DISEASE SUSCEPTIBILITY; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MAMMALIA;

EID: 34547206609     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2007.04.002     Document Type: Article

References (20)

1. Shiloh Y., and Kastan M.B. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83 (2001) 209-254
2. Bakkenist C.J., and Kastan M.B. Initiating cellular stress responses. Cell 118 (2004) 9-17
3. Lim D.-S., et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404 (2000) 613-617
4. Xu B., Kim S.-.T., and Kastan M.B. Involvement of Brca1 in S-phase and G2-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21 (2001) 3445-3450
5. Xu B., O'Donnell A.M., Kim S.-.T., and Kastan M.B. Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res. 62 (2002) 4588-4591
6. Kim S.T., Xu B., and Kastan M.B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16 (2002) 560-570
7. Kitagawa R., Bakkenist C.J., McKinnon P.J., and Kastan M.B. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18 (2004) 1423-1438
8. Bakkenist C.J., and Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421 (2003) 499-506
9. Bartkova J., et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434 (2005) 864-870
10. Gorgoulis V.G., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434 (2005) 907-913
11. Doll R., and Peto R. The causes of cancer in the United States today. J. Natl. Cancer Inst. 66 (1981) 1192-1308
12. Garcia-Cao I., et al. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21 (2002) 6225-6235
13. Bryant H.E., et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434 (2005) 913-917
14. Farmer H., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434 (2005) 917-921
15. Yang D., and Kastan M.B. Participation of ATM in insulin signalling through phosphorylation of eIF-4E binding protein 1 (4E-BP1). Nat. Cell Biol. 2 (2000) 893-898
16. Schneider J.G., et al. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 4 (2006) 377-389
17. Bae B.I., et al. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron 47 (2005) 29-41
18. Mocanu M.M., and Yellon D.M. p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. FEBS Lett. 555 (2003) 302-306
19. Guevara N.V., Kim H.S., Antonova E.I., and Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat. Med. 5 (1999) 335-339
20. Mercer J., Figg N., Stoneman V., Braganza D., and Bennett M.R. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circ. Res. 96 (2005) 667-674