Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: Evidence for decreased platelet production

British Journal of Haematology

Volumn 111, Issue 1, 2000, Pages 104-111

  Sosman, Jeffrey A ^a,c   Verma, Amit ^a   Moss, Steven ^a   Sorokin, Patricia ^a   Blend, Michael ^a   Bradlow, Basil ^a   Chachlani, Nasir ^a   Cutler, David ^a   Sabo, Ronald ^a   Nelson, Mary ^a   Bruno, Edward ^a   Gustin, David ^a   Viana, Marlos ^b   Hoffman, Ronald ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Anaemia; CFU megakaryocyte; Interleukin 10; Platelets, thrombocytopenia

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN; INTERLEUKIN 10; PLACEBO; THROMBOPOIETIN;

ADULT; ARTICLE; BURST FORMING UNIT E; CLINICAL TRIAL; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENTERITIS; FATIGUE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALAISE; MEGAKARYOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

ADULT; BLOOD PLATELETS; CELL COUNT; DOUBLE-BLIND METHOD; FEMALE; HEMOGLOBINS; HUMANS; INTERLEUKIN-10; MALE; MEGAKARYOCYTES; PLATELET COUNT; RECOMBINANT PROTEINS; SPLEEN; STATISTICS, NONPARAMETRIC; THROMBOCYTOPENIA;

EID: 0033759187     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02314.x     Document Type: Article

References (29)

1. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
2. IL-10 is key cytokine in Psoriasis
3. Feasibility of a rapid method to evaluate platelet survival time
4. Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow
5. Role of cytokines in sustaining long-term human megakaryocytopoieis in vitro
6. Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation
7. The funtional characterization of interleukin-10 receptor expression on human natural killer cells
8. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
9. Interleukin-10 upregulates tumor necrosis factor receptor type-II (p75) gene expression in endotoxin-stimulated human monocytes
10. Interleukin-10 reduces morbidity and mortality in murine multiple organ dysfunction syndrome (MODS)
11. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
12. IL-10 inhibits cytokine production by activated macrophages
13. Current status of clinical development of interleukin-10
14. Interleukin 10 inhibits growth and granulocyte/macrophage colony-stimulating factor production in chronic myelomonocytic leukemia cells
15. Interleukin-10 inhibits Erythropoietin-independent growth of erythroid bursts in patients with polycythemia vera
16. Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers
17. Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers
18. Recommended methods for indium-111 platelet survival studies
19. IL-10 as a therapeutic strategy in the treatment of rheumatoid arthritis
20. Homology of cytokine synthesis inhibitory factor (IL-10) to Epstein-Barr virus gene BCRFI
21. Interleukin-10
22. Interleukin-10 inhibits spontaneous colony-forming unit-granulocyte-macrophage growth from human peripheral blood mononuclear cells by suppression of endogenous granulocyte-macrophage colony-stimulating factor release
23. Effects of recombinant human interleukin-11 (Neumega rhIL-11 growth factor) on megakaryocytopoiesis in human bone marrow
24. + stem cells
25. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
26. Transforming growth factor-beta1 (TCF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itseff with high specificity
27. Multiple doses of intravenous interleukin-10 in steroid-refractory Crohn's disease
28. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCERI
29. Evidence suggesting a stimulatory role for interleukin-10 in erythropoiesis in vitro