Soy protein without isoflavones reduces aortic total and cholesterol ester concentrations greater than soy protein with isoflavones compared with casein in hypercholesterolemic hamsters

Nutrition Research

Volumn 27, Issue 8, 2007, Pages 498-504

  Wilson, Thomas A ^a   Nicolosi, Robert J ^a   Kotyla, Timothy ^a   Fleckinger, Brent ^b  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b ARCHER DANIELS MIDLAND COMPANY   (United States)

Author keywords

Aortic cholesterol; Casein; Hamster; Plasma cholesterol; Soy protein

Indexed keywords

ALCOHOL; CASEIN; CHOLESTEROL; CHOLESTEROL ESTER; COCONUT OIL; CORN OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE DERIVATIVE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOYBEAN PROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; FOOD COMPOSITION; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DIET; PROTEIN INTAKE; SYRIAN HAMSTER; TREATMENT RESPONSE;

CRICETINAE; GLYCINE MAX; MESOCRICETUS AURATUS; ZEA MAYS;

EID: 34547194195     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2007.05.005     Document Type: Article

References (61)

1. Meinertz H., Nilausen K., and Faergeman O. Soy protein and casein in cholesterol-enriched diets: effects on plasma lipoproteins in normolipidemic subjects. Am J Clin Nutr 50 (1989) 786-793
2. Sirtori C.R., Agradi E., Conti F., Montero O., and Gatti E. Soybean protein diet in the treatment of type II hyperlipoproteinemia. Lancet I (1977) 275-277
3. Carroll K.K., and Hamilton R.M.G. Effects of dietary protein and carbohydrate on plasma cholesterol levels in relation to atherosclerosis. J Food Sci 40 (1975) 18-23
4. Terpstra A.H.M., van Tintelen G., and West C.E. The effect of semipurified diets containing different proportions of either casein or soybean protein on the concentration of cholesterol in whole serum, serum lipoproteins and liver in male and female rats. Atherosclerosis 42 (1982) 85-95
5. Kim D.N., Lee K.T., Reiner J.M., and Thomas W.A. Effects of a soy protein product on serum and tissue cholesterol concentrations in swine fed high-fat, high-cholesterol diets. Exp Mol Pathol 29 (1978) 385-399
6. Terpstra A.H.M., West C.E., Fennis J.T.C.M., Schouten J.A., and van der Veen E.A. Hypocholesterolemic effect of dietary soy protein versus casein in rhesus monkeys (Macaca mulatta). Am J Clin Nutr 39 (1984) 1-7
7. Terpstra A.H.M., Hermus R.J.J., and West C.E. The role of dietary protein in cholesterol metabolism. World Rev Nutr Diet 42 (1983) 1-55
8. Terpstra A.H.M., Holmes J.C., and Nicolosi R.J. The hypocholesterolemic effect of dietary soybean protein vs. casein in hamsters fed cholesterol-free or cholesterol-enriched semi-purified diets. J Nutr 121 (1991) 944-947
9. Beynen A.C., and Schouten J.A. Influence of dietary soybean and casein on the level of plasma cholesterol in hamsters. Nutr Rep Int 28 (1983) 835-840
10. von Duvillard S.P., Stucchi A.F., Terpstra A.H.M., and Nicolosi R.J. The effect of dietary casein and soybean protein on plasma lipid levels in cebus monkeys fed cholesterol-free or cholesterol-enriched semi-purified diets. J Nutr Biochem 3 (1992) 71-74
11. Sacks F.M., Breslow J.L., Wood P.G., and Kass E.H. Lack of an effect of dietary protein (casein) and soy protein on plasma cholesterol of strict vegetarians. An experiment and critical review. J Lipid Res 24 (1983) 1012-1020
12. Van Raaij J.M.A., Katan M.B., Hautvast J.G.A.J., and Hermus R.J.J. Effects of casein versus soy protein diets on serum cholesterol and lipoproteins in young healthy volunteers. Am J Clin Nutr 35 (1981) 1261-1271
13. Sautier C., Doucet C., Flament C., and Lemonnier D. Effects of soy protein and saponins on serum, tissue and fecal steroids in rats. Atherosclerosis 34 (1979) 233-241
14. Barth C.A., Pfeuffer M., and Hahn G. Influence of dietary casein or soy protein on serum lipids and lipoproteins of monkeys (Macaca fascicularis). Ann Nutr Metab 28 (1984) 137-143
15. Terpstra A.H.M., Laitinen L., Stucchi A.F., and Nicolosi R.J. The effect of semipurified diets containing two levels (20% and 40%) of either casein or soybean protein isolate and concentrate on plasma lipids in hamsters. Nutr Res 14 (1994) 885-895
16. Nicolosi R.J., and Wilson T.A. The anti-atherogenic effect of dietary soybean protein concentrate in hamsters. Nutr Res 17 (1997) 1457-1467
17. Huff M.W., Hamilton R.M.G., and Carroll K.K. Plasma cholesterol levels in rabbits fed low fat, cholesterol-free, semipurified diets: effects of dietary proteins, protein hydrolysates and amino acid mixtures. Atherosclerosis 28 (1977) 187-195
18. Nagata Y., Ishiwaki N., and Sugano M. Studies on the mechanism of the anti-hypercholesterolemic action of soy protein and soy protein-type amino acid mixtures in relation to their casein counterparts in rats. J Nutr 112 (1982) 1614-1625
19. Tasker T.E., and Potter S.M. Effects of dietary protein source on plasma lipids, HMG-CoA reductase activity, and hepatic glutathione levels in gerbils. J Nutr Biochem 4 (1993) 458-462
20. Potter S.M. Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr 125 Suppl (1995) 606-611
21. Wilson T.A., Meservey C.M., and Nicolosi R.J. The hypocholesterolemic and anti-atherogenic effects of soy lecithin in hypercholesterolemic hamsters: beyond linoleate. Atherosclerosis 140 (1998) 147-153
22. Topping D.L., Storer G.B., Calvert G.D., Illman R.J., Oakenfull D.G., and Weller R.A. Effects of dietary saponins on fecal bile acids and neutral sterols, plasma lipids, and lipoprotein turnover in the pig. Am J Clin Nutr 33 (1980) 783-786
23. Woodward C.J.H., and Carroll K.K. Digestibilities of casein and soy-bean protein in relation to their effects on serum cholesterol in rabbits. Br J Nutr 54 (1985) 355-366
24. Samman S., and Roberts D.C.K. The phosphorylation state of casein and its hypercholesterolemic effect: the role of divalent cations. Atherosclerosis 52 (1984) 347-348
25. Merz-Demlow B.E., Duncan A.M., Wangen K.E., Xu X., Carr T.P., Phillips W.R., et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 71 (2000) 1462-1469
26. Nestel P.J., Yamashita T., Sasahara T., Pomeroy S., Dart A., Komesaroff P., et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 17 (1997) 3392-3398
27. Hodgson J.M., Puddey I.B., Beilin L.J., Mori T.A., and Croft K.D. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 128 (1998) 728-732
28. Allain C.C., Poon L.S., Chen C.S.G., Richmond W., and Fu P.C. Enzymatic determination of total serum cholesterol. Clin Chem 20 (1974) 470-475
29. Bucolo G., and David H. Quantitative determination of serum triacylglycerols by the use of enzymes. Clin Chem 36 (1973) 476-482
30. Weingand K.W., and Daggy B.P. Quantitation of high-density lipoprotein cholesterol in plasma from hamsters by differential precipitation. Clin Chem 36 (1990) 575
31. Alexaki A., Wilson T.A., Atallah M.T., Hamndelman G., and Nicolosi R.J. Diets high in saturated fat increase cholesterol accumulation and cytokine production in the aortic arch compared to cholesterol-fedhamsters with moderately elevated plasma nonHDL concentrations. J Nutr 134 (2004) 410-415
32. Rudel L.L., Kelley K., Sawyer J.K., Shah R., and Wilson M.M. Dietary monosaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-overexpressing transgenic mice. Aterioscler Thromb Vasc Biol 18 (1998) 1818-1827
33. Snedecor G.W., and Cochran W.G. Statistical methods (1990), The Iowa State University Press, Ames (Iowa)
34. Jenkins D.J.A., Kendall C.W.C., Jackson C.J.C.J., Connelly P.W., Parker T., Faulkner D., et al. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 76 (2002) 365-372
35. Hrabek-Smith J.M., Kurowska E.M., and Carroll K.K. Effects of cholesterol-free, semipurified diets containing different levels of casein or soy protein on distribution of cholesterol and protein among serum lipoproteins of rabbits. Atherosclerosis 76 (1989) 125-130
36. Chao Y.S., Yamin T.T., and Alberts A.W. Effects of cholestyramine on low density lipoprotein binding sites on liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat starch-casein diet. J Biol Chem 257 (1982) 3623-3627
37. Beynen A.C., West C.E., Spaaiy C.J.K., Huisman J., van Leeuwen P., Schutte J.B., et al. Cholesterol metabolism, digestion rates and post prandial changes in serum of swine fed purified diets containing either casein or soybean protein. J Nutr 120 (1990) 422-430
38. West C.E., Spaaiy C.J.K., Clouds W.M., Twisk H.P., Goertz M.P.H., Hubbard R.W., et al. Comparison of the hypocholesterolemic effects of dietary soybean protein with those of formaldehyde-treated casein in rabbits. J Nutr 119 (1989) 843-856
39. Huff M.W., and Carroll K.K. Effects of dietary protein on turnover, oxidation and absorption of cholesterol, and on steroid excretion in rabbits. J Lipid Res 20 (1980) 546-558
40. US Food and Drug Administration. Food labeling: health claims; soy protein and coronary heart disease; final rule. Federal Register 64 FR 57699 October 26, 1999.
41. Wangen K.E., Duncan A.M., Xu X., and Kurzer M.S. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73 (2001) 225-231
42. Anderson J.W., Johnstone B.M., and Cook-Newell M.L. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333 (1995) 276-282
43. Anthony M.S., Clarkson T.B., Hughes C.L., Morgan T.M., and Burke G.L. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr 126 (1996) 43-50
44. Anthony M.S., Clarkson T.B., Bullock B.C., and Wagner J.D. Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis on male cynomolgus monkeys. Arterioscler Thromb Vasc Biol 17 (1997) 2524-2531
45. Bierman E.L., and Glomset J.A. In: Wilson J.D., and Foster D.W. (Eds). William's textbook of clinical endocrinology (1992), W.B. Saunders, Philadelphia (Pa) 1384-1385
46. Deeley R.G., Tam S.P., and Archer T.K. The effects of estrogen on apolipoprotein synthesis (review). Can J Biochem Cell Biol 63 (1985) 882-889
47. Sirtori C.R., Gianazza E., Manzoni C., Lovati M.R., and Murphy P.A. Role of isoflavones in the cholesterol reduction by soy protein in the clinic. Am J Clin Nutr 65 (1997) 166-171
48. Clarkson T.B., Anthony M.S., and Morgan T.M. Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens. J Clin Endocrinol Metab 86 (2001) 41-47
49. Clarkson T.B. Soy, soy phytoestrogens and cardiovascular disease. J Nutr 132 (2002) 566S-569S
50. Lichtenstein A.H., Jalbert S.M., Adlercreutz H., Goldin B.R., Rasmussen H., Schaefer E.J., et al. Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler Thromb Vasc Biol 22 (2002) 1852-1858
51. Crouse III J.R., Morgan T., Terry J.G., Ellis J., Vitolins M., and Burke G.L. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 159 (1999) 2070-2076
52. Dent S.B., Peterson C.T., Brace L.D., Swain J.H., Reddy M.B., Hanson K.B., et al. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. J Nutr 131 (2001) 2280-2287
53. Steinberg F.M., Guthrie N.L., Villablanca A.C., Kumar K., and Murray M.J. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr 78 (2003) 123-130
54. Adams M.R., Golden D.L., Williams J.K., Franke A.A., Register T.C., and Kaplan J.R. Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys. J Nutr 135 (2005) 2852-2856
55. McVeigh B.L., Dillingham B.L., Lampe J.W., and Duncan A.M. Effect of soy protein varying in isoflavone content on serum lipids in healthy young men. Am J Clin Nutr 83 (2006) 244-251
56. Lovati M.R., Manzoni C., Corsini A., Granata A., Frattini R., Fumagalli R., et al. Low density lipoprotein receptor activity is modulated by soybean globulins in cell culture. J Nutr 122 (1992) 1971-1978
57. Lovati M.R., Manzoni C., Gianazza E., and Sortori C.R. Soybean protein products as regulators of liver low-density lipoprotein receptors. I. Identification of active β-conglycinin subunits. J Agric Food Chem 46 (1998) 2474-2480
58. Adams M.R., Golden D.L., Franke A.A., Potter S.M., Smith H.S., and Anthony M.S. Dietary soy beta-conglycinin (7S globulin) inhibits atherosclerosis in mice. J Nutr 134 (2004) 511-516
59. Greaves K.A., Parks J.S., Williams J.K., and Wagner J.D. Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys. J Nutr 129 (1999) 1585-1592
60. Wagner J.D., Schwenke D.C., Greaves K.A., Zhang L., Anthony M.S., Blair R.M., et al. Soy protein with isoflavones, but not an isoflavone-rich supplement, improves arterial low-density lipoprotein metabolism and atherogenesis. Arterioscler Thromb Vasc Biol 23 (2003) 2241-2246
61. Anthony M.S., Blair R.M., and Clarkson T.B. Neither isoflavones nor the alcohol-extracted fraction added to alcohol-washed soy protein isolate restores the lipoprotein effects of soy protein isolate. J Nutr 132 (2002) 583S [abs]