Rad9 modulates the P21WAF1 pathway by direct association with p53

BMC Molecular Biology

Volumn 8, Issue , 2007, Pages

  Ishikawa, Kazuhiro ^a   Ishii, Hideshi ^a   Murakumo, Yoshiki ^b   Mimori, Koshi ^c   Kobayashi, Masahiko ^d   Yamamoto, Ken Ichi ^c   Mori, Masaki ^a   Nishino, Hiroshi ^a   Furukawa, Yusuke ^a   Ichimura, Keiichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; PROTEIN P53; PROTEIN RAD9; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; EMBRYO; GENE EXPRESSION; GENE INTERACTION; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; MUTANT; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; GENE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE;

CELL CYCLE PROTEINS; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; GENE EXPRESSION REGULATION; GENES, CDC; HUMANS; IMMUNOPRECIPITATION; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34547138668     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-8-37     Document Type: Article

References (44)

1. Dasika GK Lin SC Zhao S Sung P Tomkinson A Lee EY DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis Oncogene 1999 18 7883-7899 10.1038/sj.onc.1203283 10630641
2. Elledge SJ Cell cycle checkpoints: Preventing an identity crisis Science 1996 274 1664-1672 10.1126/science.274.5293.1664 8939848
3. Lengauer C Kinzler KW Vogelstein B Genetic instability in colorectal cancers Nature 1997 386 623-627 10.1038/386623a0 9121588
4. Caspari T Carr AM DNA structure checkpoint pathways in Schizosaccharomyces pombe Biochimie (Paris) 1999 81 173-181
5. Rhind N Russell P Mitotic DNA damage and replication checkpoints in yeast Curr Opin Cell Biol 1998 10 749-758 10.1016/S0955-0674(98)80118-X 9914174
6. St Onge RP Udell CM Casselman R Davey S The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1 Mol Biol Cell 1999 10 1985-1995 25401 10359610
7. Volkmer E Karnitz LM Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex J Biol Chem 1999 274 567-570 10.1074/jbc.274.2.567 9872989
8. Burtelow MA Roos-Mattjus PM Rauen M Babendure JR Karnitz LM Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex J Biol Chem 2001 276 25903-25909 10.1074/jbc.M102946200 11340080
9. Caspari T Dahlen M Kanter-Smoler G Lindsay HD Hofmann K Papadimitriou K Sunnerhagen P Carr AM Characterization of Schizosaccharomyces pombe Hus1: A PCNA-related protein that associates with Rad1 and Rad9 Mol Cell Biol 2000 20 1254-1262 85258 10648611 10.1128/MCB.20.4.1254-1262.2000
10. Thelen MP Venclovas C Fidelis K A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins Cell 1999 96 769-770 10.1016/ S0092-8674(00)80587-5 10102265
11. Waga S Stillman B The DNA replication fork in eukaryotic cells Annu Rev Biochem 1998 67 721-751 10.1146/annurev.biochem.67.1.721 9759502
12. Bermudez VP Lindsey-Boltz LA Cesare AJ Maniwa Y Griffith JD Hurwitz J Sancar A Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro Proc Natl Acad Sci USA 2003 18 1633-1638 10.1073/pnas.0437927100
13. Burtelow MA Kaufmann SH Karnitz LM Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage J Biol Chem 2000 275 26343-26348 10.1074/jbc.M001244200 10852904
14. Abraham RT Cell cycle checkpoint signaling through the ATM and ATR kinases Genes Dev 2001 15 2177-2196 10.1101/gad.914401 11544175
15. Bartek J Falck J Lukas J CHK2 kinase--a busy messenger Nat Rev Mol Cell Biol 2001 2 877-886 10.1038/35103059 11733767
16. Rhind N Russell P Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways J Cell Sci 2000 113 3889-3896 11058076
17. McGowan CH Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor Bioessays 2002 24 502-511 10.1002/bies.10101 12111733
18. St Onge RP Besley BD Pelley JL Davey S A role for the phosphorylation of hRad9 in checkpoint signaling J Biol Chem 2003 278 26620-26628 10.1074/ jbc.M303134200 12734188
19. Chen MJ Lin YT Lieberman HB Chen G Lee EYHP ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation J Biol Chem 2001 276 16580-16586 10.1074/ jbc.M008871200 11278446
20. Roos-Mattjus P Hopkins KM Oestreich AJ Vroman BT Johnson KL Naylor S Lieberman HB Karnitz LM Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling J Biol Chem 2003 278 24428-24437 10.1074/jbc.M301544200 12709442
21. Levine AJ p53, the cellular gatekeeper for growth and division Cell 1997 88 323-331 10.1016/S0092-8674(00)81871-1 9039259
22. Yokota J Kohno T Molecular footprints of human lung cancer progression Cancer Sci 2004 95 197-204 10.1111/j.1349-7006.2004.tb02203.x 15016317
23. El-Deiry WS Kern SE Pietenpol JA Kinzler KW Vogelstein B Definition of a consensus binding site for p53 Nature Genet 1992 1 45-49 10.1038/ ng0492-45 1301998
24. Kern SE Kinzler KW Bruskin A Jarosz D Friedman P Prives C Vogelstein B Identification of p53 as a sequence-specific DNA-binding protein Science 1991 252 1708-1711 10.1126/science.2047879 2047879
25. El-Deiry WS Tokino T Velculescu VE Levy DB Parsons R Trent JM Lin D Mercer WE Kinzler KW Vogelstein B WAF1, a potential mediator of p53 tumor suppression Cell 1993 75 817-825 10.1016/0092-8674(93)90500-P 8242752
26. Harper JW Adami GR Wei N Keyomarsi K Elledge SJ The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 1993 75 805-816 10.1016/0092-8674(93)90499-G 8242751
27. Noda A Ning Y Venable SF Pereira-Smith OM Smith JR Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen Exp Cell Res 1994 211 90-98 10.1006/excr.1994.1063 8125163
28. Kastan MB Zhan Q El-Deiry WS Carrier F Jacks T Walsh WV Plunkett BS Vogelstein B Fornace Jr. AJ A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia Cell 1992 71 587-597 1423616
29. Greer DA Besley BDA Kennedy KB Davey S hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation Cancer Res 2003 63 4829-4835 12941802
30. Bendjennat M Boulaire J Jascur T Brickner H Barbier V Sarasin A Fotedar A Fotedar R UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair Cell 2003 114 5 599-610 10.1016/ j.cell.2003.08.001 13678583
31. El-Deiry WS Tokino T Waldman T Oliner JD Velculescu VE Burrell M Hill DE Healy E Rees JL Hamilton SR Kinzler KW Vogelstein B Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues Cancer Res 1995 55 2910-2919 7796420
32. Yin Y Zhu A Jin YJ Liu YX Zhang X Hopkins KM Lieberman HB Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21 Proc Natl Acad Sci USA 2004 15 8864-8869 10.1073/pnas.0403130101
33. Koutsodontis G Kardassis D Inhibition of p53-mediated transcriptional responses by mithramycin A Oncogene 2004 23 9190-9200 15489892
34. Barnas C Martel-Planche G Furukawa Y Hollstein M Montesano R Hainaut P Inactivation of the p53 protein in cell lines derived from human esophageal cancers International journal of cancer 1997 71 1 79 -7 10.1002/(SICI)1097-0215(19970328)71:1<79::AID-IJC14>3.0.CO;2-4
35. Cheng CK Chow LW Loo WT Chan TK Chan V The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer Cancer Res 2005 65 8646-8654 10.1158/ 0008-5472.CAN-04-4243 16204032
36. Maniwa Y Yoshimura M Bermudez VP Yuki T Okada K Kanomata N Ohbayashi C Hayashi Y Hurwitz J Okita Y Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells Cancer 2005 103 126-132 10.1002/ cncr.20740 15558813
37. Shieh SY Ikeda M Taya Y Prives C DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 1997 91 325-334 10.1016/ S0092-8674(00)80416-X 9363941
38. Toueille M El-Andaloussi N Frouin I Freire R Funk D Shevelev I Friedrich-Heineken E Villani G Hottiger MO Hubscher U The human Rad9/ Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: Implications for DNA repair Nucleic Acids Res 2004 32 3316-3324 443528 15314187 10.1093/nar/ gkh652
39. Friedrich-Heineken E Toueille M Tannler B Burki C Ferrari E Hottiger MO Hubscher U The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity J Mol Biol 2005 353 980-989 10.1016/j.jmb.2005.09.018 16216273
40. Komatsu K Miyashita T Hang H Hopkins KM Zheng W Cuddeback S Yamada M Lieberman HB Wang HG Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis Nat Cell Biol 2000 2 1-6 10.1038/ 71316 10620799
41. Park YB Park MJ Kimura K Shimizu K Lee SH Yokota J Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines Cancer Genet Cytogenet 2002 133 105-111 10.1016/ S0165-4608(01)00575-1 11943335
42. Tanaka A Leung PS Kenny TP Au-Young J Prindiville T Coppel RL Ansari AA Gershwin ME Genomic analysis of differentially expressed genes in liver and biliary epithelial cells of patients with primary biliary cirrhosis J Autoimmun 2001 17 89-98 10.1006/jaut.2001.0522 11488641
43. Zapata E Ventura JL De la Cruz K Rodriguez E Damian P Masso F Montano LF Lopez-Marure R Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogen-receptor independent FEBS J 2005 272 1343-1353 10.1111/j.1742-4658.2005.04563.x 15752352
44. Itoh H Hattori Y Sakamoto H Ishii H Kishi T Sasaki H Yoshida T Koono M Sugimura T Terada M Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity Cancer Res 1994 54 3237-3241 8205545