Microsatellite instability and frameshift mutations in BAX and transforming growth factor-β RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines

Blood

Volumn 92, Issue 1, 1998, Pages 230-233

  Molenaar, Jan J ^b   Gérard, Bénédicte ^b   Chambon Pautas, Cécile ^b   Cavé, Hélène ^b   Duval, Michel ^b   Vilmer, Etienne ^b   Grandchamp, Bernard ^a  

^a INSERM   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; BASE MISPAIRING; CHILD; CONTROLLED STUDY; DNA REPAIR; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL;

EID: 2642636861     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.1.230.413k17_230_233     Document Type: Article

References (28)

1. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR, Peterson GM, Kinzler KW, Vogelstein B, de la Chapelle A: Clues to the pathogenesis of familial colorectal cancer. Science 260:816, 1993
2. Eshleman JR, Markowitz SD: Mismatch repair defects in human carcinogenesis. Hum Mol Genet 5:1489, 1996
3. Modrich P, Lahue R: Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu Rev Biochem 65:101, 1996
4. Eshelman JR, Lang EZ, Bowerfind GK, Parsons R, Vogelstein B, Wilson JKV, Veigl ML, Sedwick WD, Markowitz SD: Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene 10:33, 1995
5. Perucho M: Microsatellite instability: The mutator that mutates the other mutator. Nature Med 6:630, 1996
6. Boyer JC, Umar A, Risinger JI, Lipford JR, Kane M, Yin S, Barret JC, Kolodner RD, Kunkel TA: Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res 55:6063, 1995
7. Parsons R, Li GM, Longley M, Modrich P, Liu B, Berk T, Hamilton SR, Kinzler KW, Vogelstein B: Mismatch repair deficiency in phenotypically normal human cells. Science 268:738, 1995
8. Benson JR, Wells K: Microsatellite instability and a TGFβ receptor: Clues to a growth control pathway. Bioessays 17:1009, 1995
9. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV: Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability. Science 268:1336, 1995
10. Izumoto S, Arita N, Ohnishi T, Hiraga S, Taki T, Tomita N, Ohue M, Hayakawa T: Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas. Cancer Lett 112:251, 1997
11. Markowitz SD, Roberts AB: Tumor suppressor activity of the TGF-β pathway in human cancers. Cytokine Growth Factor Rev 7:93, 1996
12. Rammpino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, Perucho M: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275:967, 1997
13. Wind de N, Dekker M, Berns A, Radman M, Rieleter H: Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82:321, 1995
14. Baker SM, Bronner CE, Zhang L, Plug AW, Rodatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N, Flavell RA, Liskay M: Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82:309, 1995
15. Lowsky R, DeCouteau JF, Reitmair AH, Ichinohasama R, Dong WF, Xu Y, Mak TW, Kadin ME, Minden MD: Defects of the mismatch repair gene Msh2 are implicated in the development of murine and human lymphomas and are associated with the aberrant expression of rhombotin-1 (Lmo-2) and Tal-1 (SCL). Blood 89:2276, 1997
16. Haingaishi A, Seishi O, Mitani K, Hosoya N, Chiba S, Yazaki Y, Hirai H: Mutations and loss of expression of a mismatch repair gene, hMLH1 in leukemia and lymphoma cell lines. Blood 89:1740, 1997
17. Baccichet A, Benachenhou N, Couture F, Leclerc JM, Sinnett D: Microsatellite instability in childhood T cell acute lymphoblastic leukemia. Leukemia 11:797, 1997
18. Robledo M, Martinez B, Arranz E, Trujillo MJ, Gonzalez Ageitos A, Rivas C, Benitez J: Genetic instability of microsatellites in hematological neoplasms. Leukemia 9:960, 1995
19. Indraccolo S, Simon M, Hehlman R, Erfle V, Chieco-Bianchi L, Leib-Moesch C: Genetic instability of dinucleotide repeat-rich region in three hematologic malignancies. Leukemia 9:1517, 1995
20. Gartenhaus R, Johns MM III, Wang P, Rai K, Sidransky D: Mutator phenotype in a subset of chronic lymphocytic leukemia. Blood 87:38, 1996
21. Takeuchi S, Tasaka T, Koike M, Cho SK, Park S, Slater J, Mufti I, Hatta Y, Miyoshi I, Bartram CR, Koeffler HP: Microsatellite instability and other molecular abnormalities in childhood leukaemia. Br J Haematol 98:134, 1997
22. Pabst T, Schwaller J, Bellomo MJ, Oestreicher M, Mublematter D, Tichelli A, Tobler A, Fey MF: Frequent clonal loss of heterozygosity but scarcity of microsatellite instability at chromosomal breakpoint cluster regions in adult leukemias. Blood 88:1026, 1996
23. Wooster R, Cleton-Jansen AM, Collins N, Mangion J, Cornells RS, Cooper CS, Gusterson BA, Ponder, Deimling von A, Wiestler OD, Cornelisse CJ, Devilee P, Stratton MR: Instability of short tandem repeats (microsatellites) in human cancers. Nature Genet 6:152, 1994
24. Weber JL, Wong C: Mutation of short tandem repeats. Hum Mol Genet 8:1123, 1993
25. Cave H, Guidai C, Elion J, Vilmer E, Grandchamp B: A low rate of loss of heterozygosity is found at many different loci in childhood B-lineage acute lymphocytic leukemia. Leukemia 10:1486, 1996
26. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J: The 1993-94 Genethon human genetic linkage map. Nature Genet 7:246, 1994
27. kip1. Blood 86:3869, 1995
28. Meijerink JPP, Smetsers TFCM, Sloetjes AW, Linders EHP, Mensink EJBM: Bax mutations in cell lines derived from hematological malignancies. Leukemia 9:1828, 1995