Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin-induced shock

Critical Care

Volumn 10, Issue 2, 2006, Pages

  Wiel, Eric ^a   Costecalde, Marion Elizabeth ^a   Lebuffe, Gilles ^a   Corseaux, Delphine ^a   Jude, Brigitte ^a   Bordet, Régis ^a   Tavernier, Benoît ^a   Vallet, Benoît ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; CD31 ANTIGEN; DROTRECOGIN; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; THROMBOPLASTIN; ENDOTOXIN; ENDOTOXIN, ESCHERICHIA COLI; PROTEIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG RESPONSE; DRUG SENSITIVITY; ENDOTHELIUM INJURY; ESCHERICHIA COLI; HEMOSTASIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; RABBIT; SEPTIC SHOCK; SINGLE DRUG DOSE; VASCULAR ENDOTHELIUM; VASCULAR RING; VASOCONSTRICTION; ANIMAL; BLOOD; COMPARATIVE STUDY; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ENDOTOXINS; HUMANS; MALE; PROTEIN C; RABBITS; SHOCK, SEPTIC; VASOCONSTRICTION;

EID: 34447644600     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc4858     Document Type: Article

References (39)

1. Hotchkiss RS Karl IE The pathophysiology and treatment of sepsis N Engl J Med 2003 348 138-150 10.1056/NEJMra021333 12519925
2. Kang YH Williams R Endotoxin-induced endothelial injury and subendothelial accumulation of fibronectin in rat aorta Anat Rec 1991 229 86-102 1996787 10.1002/ar.1092290110
3. Young JS Headrick JP Berne RM Endothelial-dependent and -independent responses in the thoracic aorta during endotoxic shock Circ Shock 1991 35 25-30 1742858
4. Parker JL Adams HR Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia Circ Res 1993 72 539-551 7679334
5. Reidy MA Bowyer DE Scanning electron microscopy: Morphology of aortic endothelium following injury by endotoxin and during subsequent repair Atherosclerosis 1977 26 319-328 10.1016/0021-9150(77)90084-3 322678
6. Lee M Schuessler G Chien S Time dependent effects of endotoxin on the ultrastructure of the aortic endothelium Artery 1988 15 71-89 3281633
7. Leclerc J Pu Q Corseaux D Haddad E Decoene C Bordet R Six I Jude B Vallet B A single endotoxin injection in rabbit causes prolonged blood vessel dysfunctions and procoagulant state Crit Care Med 2000 28 3672-3678 10.1097/00003246-200011000-00023 11098972
8. Abraham E Effects of recombinant human activated protein C in human models of endotoxin administration Proc Am Thorac Soc 2005 2 243-7 10.1513/pats.200501-004AC 16222045
9. Wiel E Pu Q Corseaux D Robin E Bordet R Lund N Jude B Vallet B Effect of L-arginine on endothelial injury and hemostasis in rabbit endotoxin shock J Appl Physiol 2000 89 1811-1818 11053330
10. Pu Q Wiel E Corseaux D Bordet R Azrin MA Ezekowitz MD Lund N Jude B Vallet B Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endooxin-induced shock Crit Care Med 2001 29 1181-1188 10.1097/00003246-200106000-00019 11395599
11. Wiel E Pu Q Leclerc J Corseaux D Bordet R Lund N Jude B Vallet B Effects of the angiotensin-converting enzyme inhibitor perindopril on endothelial injury and hemostasis in rabbit endotoxic shock Intensive Care Med 2004 30 1652-1659 10.1007/s00134-004-2198-4 15024568
12. Wiel E Lebuffe G Robin E Gasan G Corseaux D Tavernier B Jude B Bordet R Vallet B Pretreatment with peroxysome proliferator-activated receptor (PPAR)-alpha agonist, fenofibrate, protects endothelium in rabbit Escherichia coli endotoxin-induced shock Intensive Care Med 2005 31 1269-1279 10.1007/s00134-005-2730-1 16132896
13. Wiel E Vallet B Ten Cate H The endothelium in intensive care Crit Care Clin 2005 21 403-416 10.1016/j.ccc.2005.03.001 15992664
14. Esmon CT The protein C anticoagulant pathway Arterioscler Thromb 1992 12 135-145 1311945
15. Riewald M Ruf W Science review. Role of coagulation protease cascades in sepsis Crit Care 2003 7 123-129 270604 12720558 10.1186/cc1825
16. Yan SB Helterbrand JD Hartman DL Wright TJ Bernard GR Low levels of protein C are associated with poor outcomes in severe sepsis Chest 2001 120 915-922 0.1378/chest.120.3.915 11555529
17. Hoffmann JN Vollmar B Laschke MW Inthorn D Fertmann J Schildberg FW Menger MD Microhemodynamic and cellular mechanism of activated protein C action during endotoxemia Crit Care Med 2004 32 1011-1017 10.1097/ 01.CCM.0000120058.88975.42 15071394
18. Jackson CV Bailey BD Shetler TJ Pharmacological profile of recombinant human activated protein C (LY203638) in a canine model of coronary artery thrombosis J Pharmacol Exp Ther 2000 295 967-971 11082430
19. Hamon M Vallet B Bauters C Wernert N McFadden EP Lablanche JM Dupuis B Bertrand ME Long-term oral administration of L-arginine reduces intimal thickening and enhances neo-endothelium-dependent acetylcholine-induced relaxation after arterial injury Circulation 1994 90 1357-1362 8087946
20. Carson S Continuous chromogenic tissue factor assay: Comparison to clot-based assays and sensitivity established using pure tissue factor Thromb Res 1987 47 379-387 10.1016/0049-3848(87)90453-1 3660349
21. Corseaux D Le Tourneau T Six I Ezekowitz MD Mc Fadden EP Meurice T Asseman P Bauters C Jude B Enhanced monocyte tissue factor response after experimental balloon angioplasty in hypercholesterolemic rabbit: inhibition with dietary L-arginine Circulation 1998 98 1776-1782 9788833
22. Taylor FB Chang A Esmon CT D'Angelo A Vigano-D'Angelo S Blick KE Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon J Clin Invest 1987 79 918-925 424237 3102560
23. Roback MG Stack AM Thompson C Brugnara C Schwartz HP Saladino RA Activated protein C concentrate for the treatment of meninogococcal endotoxin shock in rabbits Shock 1998 9 138-142 9488260
24. Gruber A Griffin JH Harker LA Hanson SR Inhibition of platelet-dependent thrombus formation by activated protein C in a primate model Blood 1989 73 639-642 2917194
25. Taylor FB Stearns-Kurosawa DJ Kurosawa S Ferrell G Chang A Laszik Z Kosanke S Peer G Esmon CT The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis Blood 2000 95 1680-1686 10688824
26. Derhaschnig U Reiter R Knöbl P Baumgartner M Keen P Jilma B Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia Blood 2003 102 2093-2098 10.1182/blood-2003-02-0416 12750166
27. Hollenstein U Homoncik M Knöbl P Pernerstorfer T Graggaber J Eichler HG Handler S Jilma B Acenocoumarol decreases tissue factor-dependent coagulation during systemic inflammation in humans Clin Pharmacol Ther 2002 71 368-374 12011822 10.1067/mcp.2002.123596
28. Pernerstorfer T Hollenstein U Hansen J Knechtelsdorfer M Stohlawetz P Graninger W Eichler HG Speiser W Jilma B Heparin blunts endotoxin-induced coagulation activation Circulation 1999 100 2485-2490 10604885
29. deJonge E Dekkers PE Creaseay AA Hack CE Paulson SK Karim A Kesecioglu J Levi M van Deventer SJ van der Poll T Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia Blood 2000 95 1124-1129 10666180
30. Grinnell BW Yan SB Novel antithrombotics based on modulation of protein C pathway Coron Artery Dis 1998 9 89-97 9647409
31. Shua F Kobayashia H Fukudome K Tsuneyoshib N Kimotob M Teraoa T Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner FEBS Lett 2000 477 208-212 10.1016/S0014-5793(00)01740-3 10908722
32. Joyce DE Gelbert L Ciacca A DeHoff B Grinnell BW Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis J Biol Chem 2001 276 11199-11203 10.1074/ jbc.C100017200 11278252
33. Hotchkiss RS Tinsley KW Swanson PE Karl IE Endothelial cell apoptosis in sepsis Crit Care Med 2002 30 S225-S228 10.1097/00003246-200205001-00009 12004240
34. Cheng T Liu D Griffin JH Fernandez JA Castellino F Rosen ED Fukudome K Zlokovic BV Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat Med 2003 9 338-342 10.1038/nm826 12612568
35. Isobe H Okajima K Uchiba M Mizutani A Harada N Nagasaki A Okabe H Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide Circulation 2001 104 1171-1175 11535575
36. Vallet B Wiel E Endothelial cell dysfunction and coagulation Crit Care Med 2001 29 S36-S41 10.1097/00003246-200107001-00015 11445732
37. Riewald M Ruf W Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling J Biol Chem 2005 280 19808-19814 10.1074/ jbc.M500747200 15769747
38. Monnet X Lamia B Anguel N Richard C Bonmarchand G Teboul JL Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients Intensive Care Med 2005 31 1573-1576 10.1007/s00134-005-2792-0 16175347
39. Bhattacharya A Grinnell BW Cohen ML Unlike thrombin, protein C and activated protein C do not affect vascular tone Peptides 2000 21 1231-1236 10.1016/S0196-9781(00)00264-3 11035210