Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3681-3690

  Mbadugha, Bessie N A ^a   Seo, Jiwon ^a   Ji, Haitao ^a   Martásek, Pavel ^b   Roman, Linda J ^b   Shea, Thomas M ^b   Li, Huiying ^c,d   Poulos, Thomas L ^c,d   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Computer modeling; Enzyme inhibitors; Hydroxyl terminated; Neuronal nitric oxide synthase; Nitric oxide synthase; Peptidomimetic

Indexed keywords

AMINE; GUANIDINE DERIVATIVE; N [4 AMINO 5 (2 HYDROXYETHYL)AMIDOPENTYL] N NITROGUANIDINE; N [4 AMINO 5 (2 HYDROXYETHYL)AMINOPENTYL] N NITROGUANIDINE; N [4 AMINO 5 (2 HYDROXYPROPYL)AMINOPENTYL] N NITROGUANIDINE; N [4 AMINO 5 (3 HYDROXYPROPYL)AMIDOPENTYL] N NITROGUANIDINE; N [4 AMINO 5 (4 HYDROXYBUTYL)AMIDOPENTYL] N NITROGUANIDINE; N [4 AMINO 5 (4 HYDROXYBUTYL)AMINOPENTYL] N NITROGUANIDINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; DRUG BIOAVAILABILITY; DRUG POTENCY; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; NONHUMAN; RAT; X RAY ANALYSIS;

ANIMALS; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRIC OXIDE SYNTHASE TYPE I; PEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646017693     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.044     Document Type: Article

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