Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases

Biochemistry

Volumn 44, Issue 46, 2005, Pages 15222-15229

  Li, Huiying ^a   Flinspach, Mack L ^a   Igarashi, Jotaro ^a   Jamal, Joumana ^a   Yang, Weiping ^a   Gómez Vidal, José Antonio ^b   Litzinger, Elizabeth A ^b   Huang, Hui ^b   Erdal, Erik P ^b   Silverman, Richard B ^c   Poulos, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; ELECTROSTATICS; ENZYME INHIBITION; NITROGEN OXIDES;

BINDING CONFORMATIONS; DIPEPTIDES; ISOFORMS; NITRIC OXIDE SYNTHASE (NOS);

ENZYMES;

AMIDE; ASPARAGINE; ASPARTIC ACID; DIPEPTIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; METHIONINE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ANIMALS; CATTLE; CRYSTALLIZATION; GUANIDINES; MANNITOL; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; NITRO COMPOUNDS; NITROARGININE; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; X-RAY DIFFRACTION;

EID: 27944454817     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0513610     Document Type: Article

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